Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID15972 Torin-2 GSE70138 MCF10A Human 24h 10uM EID0004
Types Number Response transcription factors
Up-regulation 411 TSC22D3; DMTF1; HBP1; CALCOCO1; NCOA3; ZNF500; ZNF688; ZNF93; EZH1; SCAI; PNRC1; ZNF345; ZNF117; HINFP; ZBTB16; CIR1; CBFA2T2; ZNF362; ZNF85; ZNF611; ZBTB44; ESR2; ZNF440; NHLH1; ZNF254; NR2C1; LZTR1; HDAC5; SOX3; IRF9; ZFHX2; POU6F1; NR5A1; ZKSCAN4; SOX4; MXI1; PRDM9; CRX; THRB; ZNF701; CARF; PRDM2; MEF2C; ZNF43; PHF1; ZKSCAN3; INSM1; ZBTB3; ZNF224; ZNF573; ZBTB20; ZNF133; POU2F3; ZXDB; POU2AF1; CEBPD; GFI1; HNF4G; GLI2; TBX6; GBX2; PBXIP1; RSF1; ZNF334; HESX1; ZNF682; ZNF768; NEUROG3; TULP2; SIX6; KLF8; JUP; ZNF337; ZNF76; RING1; ING4; ZNF257; BRF2; ZNF354A; RFX3; TRIM22; ZNF506; ZNF814; BRWD1; ERBB4; ONECUT1; MAML3; TULP1; ZSCAN16; ZNF33B; SNAPC4; MLLT1; NR6A1; SOX14; CBX7; SRY; VHL; ZNF778; WNT4; HIF3A; PRDM14; POU6F2; SPI1; CIITA; SOX1; ATOH1; ZIC3; IRX4; YEATS2; ZNF446; POU4F3; EMX1; ZNF675; SALL2; DCC; CHD2; ZNF430; DLX2; TBX5; ZNF80; NKX6-1; ZNF44; ZNF471; SCRT1; ZMIZ2; NPAS1; PHIP; MYF5; TAF1C; KLF7; ZNF219; TBX21; ZSCAN9; FOXH1; HEYL; TBX4; CREBL2; PEX14; ZNF654; AFF2; FEZF2; ZNF91; ZNF208; SHOX; L3MBTL1; CDIP1; XBP1; ZNF667; ZNF81; THAP9; NR1H4; TRIP11; CBX4; HDAC6; HMBOX1; ZNF358; PROP1; ZFY; GSC2; ZNF507; SIN3B; ZSCAN2; DDIT3; ZNF444; NEUROG2; KDM5A; DYRK1B; GCM2; CERS4; JUND; VENTX; ZNF292; ZNF225; ZNF674; LIN28A; ZNF467; ZNF160; HOXD12; ZNF34; POU1F1; ZNF623; ZNF492; TLX1; ZNF407; ZNF510; PAX4; APBB1; NEUROD1; ZXDC; GON4L; YBX2; ZNF536; ASCL3; ZFP2; ZKSCAN1; MYBL1; ZNF177; RXRB; PCGF3; LHX3; ZNF780B; PRDM4; ZNF214; ZNF695; SUPT3H; KLF6; HSF4; MED12; RORA; TBR1; NR1I3; ZNF273; ZNF112; TEAD3; PAWR; HMGXB3; ZNF426; ZNF141; SOX18; TCF7; ZNF75D; SETDB1; ZNF155; ZNF84; ZNF606; TP73; NAB2; STAT2; SMARCC2; ATF4; ZNF350; IRF7; HOXD1; ZNF135; INSR; DLX5; GCM1; ID4; ZBTB17; ZNF250; MZF1; DLX4; ZNF132; TCF25; TERF2; ZNF268; POU5F1B; CSDC2; ZNF223; ZNF12; SRCAP; HOXB1; MBD4; ZNF14; ZNF589; ZNF235; TCF7L1; ZNF154; PIAS4; ZNF136; IRF8; POU4F1; FOXN3; ZNF107; EP300; ZNF253; PRDM12; HOXC4; FOXO1; KDM5D; CDK9; BPTF; ZBTB43; NCOA2; CBFA2T3; SOX21; ZNF248; CAMTA2; ZNF415; ZNF671; ATF3; RBPJ; MAPK8IP1; ARID3B; ZNF74; ZNF423; FOXO3; IRF6; TGFB1I1; NANOG; PSPC1; PHF20; TOX3; KLF11; ZBTB48; NR1H3; TBX1; BAZ2A; PRDM10; KLF3; ZNF83; ZMIZ1; SOX2; ST18; NKX3-2; SKIL; GTF2IRD1; HSF1; PRDM1; HOXC11; CAMTA1; MEOX1; HMX1; NR1I2; ZNF239; TSG101; BTG1; TBX3; CEBPE; LMCD1; SIX3; ZNF3; ZNF195; KAT2B; TCF4; BNC2; ZNF217; RCOR3; RORC; ZNF665; NFKB2; NR5A2; HTATIP2; ZSCAN18; FOXF2; DAXX; KLF13; PAX5; ZNF165; HLX; ZNF24; MYRF; TGIF2; TLE2; CUX2; ERBB2; ELF4; BCL11A; OVOL2; SMARCA1; HDAC9; TCEA2; TRIB3; ZNF266; PROX1; PGR; ZNF264; CHD9; VPS72; TULP3; BHLHE41; ZNF232; ZNF587; TRPS1; ZHX2; BAZ2B; TCF7L2; ELF5; ZNF544; UBE2B; ZNF304; PAX6; ZNF419; ARID4B; CTBP2; ZNF394; CARHSP1; SHOX2; TFEC; HIC2; GRHL2; TGIF1; FOXF1; SOX10; TCF3; SOX17; ARNT2; AR; BCL6; AEBP1; SSBP3; ZNF189; BACH1; TAL1; BACH2; SOX11; TRIM29; NKX2-2; NFATC4; ARID5B; MAFB; OSR2; ZFPM2; HMG20B; ZIC1; GATA6; ASCL1; MEIS2; TLE4; FOXO4; SPDEF
Down-regulation 110 CCNA2; MYCBP; PARP1; GTF2A2; ADRB2; HDAC2; EED; MYC; NUP62; TFAM; DRAP1; SUB1; RUVBL1; RBM14; C1QBP; HOXA5; MYBL2; HMGB1; RBBP7; DR1; FOSL1; RAN; HSF2; BMI1; BCLAF1; HLTF; HOXB7; CBFB; RHOA; SUV39H1; TFDP1; HMGB2; DEK; PTTG1; ENO1; EZH2; SMARCA5; C1D; HOXA10; EGR1; PCBD1; UBP1; PA2G4; TP53; NFKB1; ILF2; TAF9B; URI1; CEBPZ; STAT3; NPM1; HMGA2; RBBP4; TRIM28; MED21; SFPQ; RUVBL2; MED6; HNRNPD; RNF6; PITX1; ZMYND11; CTR9; EDF1; HES1; ZFP64; XRCC6; RNF4; CCDC59; PIR; BAZ1A; ZBTB38; SMARCA2; HIPK3; YWHAB; CRY1; PURA; SSRP1; ETS2; TBPL1; CENPF; NR2F2; ATF1; BASP1; ZNF146; LEF1; MAGED1; IRX5; BHLHE40; JUNB; CALR; BIRC2; HSBP1; ING2; CCNC; WWTR1; CCNE1; ID1; ELK3; JARID2; THAP11; ZBTB18; PUF60; HOXB6; FLNA; ELF1; ETV1; SAP30; EGR3; HOXC6