Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID15923 Gsk-1059615 GSE70138 MCF10A Human 24h 10uM EID0004
Types Number Response transcription factors
Up-regulation 704 TSC22D3; PNRC1; ZNF500; CALCOCO1; ZKSCAN4; HBP1; PRDM2; ZNF467; CBFA2T2; ZBTB3; HINFP; ZNF85; NHLH1; SPI1; FOXH1; ZNF701; ZNF93; ZSCAN16; ZNF34; TAF1C; IRF9; POU6F1; NCOA3; ERBB4; ZNF573; EMX1; ZNF345; CDIP1; ZNF254; SALL2; HIF3A; PHF1; ZNF665; ZNF225; TP73; POU2F3; ZNF688; SOX3; FOXE3; ZBTB44; ZNF814; ZNF331; ZNF682; RFX1; NR5A1; ZNF257; ZNF75D; ZNF675; SCAI; PRDM9; SRY; MAML3; ZNF235; PROP1; HNF4G; DLX2; ZNF549; ZNF117; ZKSCAN3; GFI1; TRIM22; ZNF362; ZNF141; CRX; CREBL2; ZNF350; NEUROD6; ZNF623; BRWD1; ZNF557; NR1I3; ZNF221; HESX1; NEUROG3; RFX3; ZNF33B; ZNF253; RING1; CBX7; POU6F2; ZNF606; ZNF589; PPARA; ALX4; ZSCAN9; THRB; NFE2L2; TBX1; ZXDB; EZH1; SOX14; TULP1; ATOH1; ID4; ZNF273; LZTR1; ZNF440; PRDM14; ZNF157; E4F1; SIX6; GLI2; DCC; ZNF222; ZNF132; TBX5; SCRT1; CEBPD; ZNF80; VHL; RBPJL; ZNF442; FEZF2; MXI1; CUX2; WNT4; ZBTB7C; ONECUT1; ZNF471; TBX4; PAX4; ZXDC; ZNF674; IKZF2; THAP9; HOXD3; ZNF81; CIR1; HDAC5; ZNF354A; ZNF492; ZNF446; ZNF695; ZNF444; ZNF611; ETV3; MYBL1; BNC2; ZNF506; MED12; GSC2; HOXA6; ZNF654; ZNF223; PLAG1; ZNF407; GCM2; NR6A1; KLF8; ZNF43; ZNF250; ZNF214; ZNF778; FOXL1; DOT1L; ZNF234; ZNF669; HSF4; ZNF175; TULP2; ETV2; CHD2; ZFHX2; VENTX; FOXD3; PIAS4; ZNF550; GBX2; MAK; RSF1; SOX2; ZNF334; YEATS2; ZKSCAN8; ST18; ZNF780B; SP1; ZNF749; ZNF112; LHX3; ZNF136; GCM1; ASCL2; SHOX; ZNF76; TDRD3; ZSCAN31; BARX1; ZFP2; ZNF507; NPAS1; KAT2B; ZNF74; POU1F1; TFAP2A; CARF; EN1; PCGF3; ZNF135; ZNF480; SP4; ZNF41; NEUROG2; SMAD9; HLX; ETV6; ZIC3; ZNF155; FLI1; KLF11; TBR1; ZNF174; HIC1; TGIF2; ZKSCAN5; TBX6; ZIC4; ZNF154; MLLT1; TCF25; THRA; ZNF571; ZNF79; CERS4; ZNF16; TXNIP; AIRE; FOXN1; ZNF91; MYF5; ZNF177; ZNF613; NEUROD2; CDX1; ING4; ZNF180; POU4F3; LMX1B; ZNF391; L3MBTL1; MED25; BANP; ELK4; DLX5; AFF3; ASCL3; ZNF133; ZNF343; GRIP1; POU3F4; SOX18; DAXX; BCL11A; MAP3K10; POU3F3; ZNF667; PAX7; SOX21; MECP2; IKZF3; ZNF10; HOXB8; ETV7; ZNF44; HEYL; PITX3; SOX1; ARNT; DLX4; ZNF770; ZNF84; SKIL; TULP3; ZIM2; FOXB1; PDX1; TONSL; DYRK1B; RORC; CBFA2T3; MZF1; HOXD12; NR1H2; LIN28A; TBL1Y; TEAD3; ZNF14; TUB; SNAPC4; NFKB2; PRDM12; PRDM16; ARID3A; ATF3; VGLL1; HOXC8; PHIP; TRIP11; NOCT; ZNF8; IKZF4; MSX2; AFF2; ZNF430; CDX4; CIITA; ZNF510; ARID3B; ZNF415; MLLT10; BRDT; SETDB1; THAP3; CSDC2; ARID5A; NKX3-2; ZBTB16; POU2AF1; MEIS2; TBX10; SIX3; HOXA3; HNF4A; MXD3; ZSCAN2; HMBOX1; CBL; ZNF107; AEBP1; ZNF337; ZSCAN18; HAND2; ESRRB; UTF1; GLI1; TLX2; HOXD1; ALX3; ZNF208; TTF2; NR1H4; FOXC2; SAP130; TCF21; NR3C1; SSX7; ZNF224; TFDP3; ZNF671; ZNF816; ZNF529; PBXIP1; TFAP4; CCNH; LBX1; PKNOX2; NKX6-1; GATA6; BAZ2B; ZNF140; ATF7; TLX3; TSHZ2; SIX5; ZNF239; ZBTB20; LYL1; PEX14; ZNF268; PGR; NAB2; TEF; HDAC9; HOXB3; APBB1; MDM4; TBX21; ZNF711; VSX1; MEOX1; CBX2; RAX; MEF2C; HDAC11; WT1; SIRT2; ZHX2; NEUROD4; SHOX2; NFE2L3; TAF5L; SOX17; SIN3B; HEY2; PRDM10; NRL; HOXC5; E2F4; TCF7L2; BTG1; ZBTB17; BACH1; ZNF493; NANOG; POLR3C; TAF4B; POU3F2; HOXB1; ZNF768; PAX3; FOXJ1; ZBTB7B; PRDM13; MYRF; TAF6L; SOX5; ZNF304; JAK2; ZSCAN32; NR4A3; HOXA2; ZNF83; JUND; MNDA; TCEA2; SUPT5H; ZEB1; KLF7; PBX1; ZNF835; SUPT6H; TCF7; CEBPE; MAPK8IP1; SPIB; SOHLH2; RXRB; ZNF287; MYCL; SUPT7L; STAT2; PBX3; HIRA; PRDM1; HOXD13; FOXI1; KLF9; ZNF184; FOXP3; ZNF219; ZFHX3; TRIB3; HOXA4; TRPS1; PPARD; ZFPM2; NEUROG1; TCF7L1; HNF1B; ZNF426; MBD1; CRTC1; ZNF423; BCL6; ZNF195; VAX2; ZNF124; LHX1; KLF3; SOX4; HOXC4; ELF5; TGIF1; DMRT1; HOXC11; ZNF358; ELF4; GBX1; ATF2; FOXO1; SSBP3; SOX13; ZNF264; MED14; MBD4; ARID5B; KLF13; NR3C2; HIC2; GRHL2; GON4L; WHSC1L1; E2F8; RFX2; NR2E1; RARG; SALL1; NCOA2; NR2C1; RAD21; SUPT3H; NR5A2; SIM1; HMX1; ZBTB14; ZNF562; ARL2BP; TBX19; CBX4; VPS72; EP300; BPTF; EHMT1; CAMTA1; PRDM5; ZNF202; TLE2; DACH1; EVX1; POU5F1B; NR0B2; IRF6; NEUROD1; BNC1; ZBTB48; FOXJ2; BACH2; THAP7; KDM5C; IRF7; ZBTB39; TDP2; INSM1; PAX1; ZFP30; ZNF232; TERF2; CAMTA2; RCOR3; KDM4C; SNAI1; ZNF160; PRRX1; NFIL3; RFXANK; SMARCC2; NR1I2; TOX4; ZNF274; SUMO1; KLF15; ZBTB6; YBX2; TBX3; BRCA2; NR4A2; LMO1; ZNF419; PEG3; PROX1; ZNF3; ZFP69B; ZNF217; NCOA1; DBP; FOXN3; RARB; ACTL6B; ZNF552; FOXE1; NFE2; OSR2; TGFB1I1; ZNF227; POU4F2; SKI; LHX2; PAWR; NFIX; HOXB5; POU2F2; ZKSCAN7; ZNF544; ZNF211; ELF2; GATA3; ZNF200; BAZ2A; TCF4; ZNF324; ZNF12; HSF1; CDX2; ZNF536; NHLH2; HIPK1; TAF11; TFEB; ZNF7; ZKSCAN1; FOXF2; DDIT3; AR; ZNF394; ZNF432; HOXB2; HHEX; HOXB13; NFATC4; REL; ZNF32; TFEC; ZFY; TCF3; TLE4; OVOL2; TAL1; LMCD1; ZFP37; ZNF443; ZNF45; FOS; TFDP2; ZNF205; SMAD6; NFATC1; THAP10; PIAS1; BRIP1; SRCAP; HEY1; ZNF266; FOXF1; FOXO3; TSG101; IFI16; ZNF302; GATA4; PHF20; KLF4; HIPK2; RBPJ; SPDEF; INSR; EPAS1; ZIC1; NR4A1; ZNF165; ZNF580; MDM2; SP100; PAX5; ESR1; ZNF329; SP140L; MED17; EHF; ZNF24; ZBTB43; IRF8; CHD9; PAX6; MEIS1; TCF15; NKX2-1; FOXL2; ZNF22; CITED2; MAFB; MKL2; SUPT4H1; ZNF131; FUBP1; RELB; BHLHE41; SMARCA1; OLIG2; FOXA2; TWIST1; UBE2B; CD3D; CRYM; FOSB; ARNT2; TFAP2C; MYB; MAF; SSBP2; NFATC3; CTBP2; NKX2-2; CREB3L2; SOX11; MEOX2; CUX1; FOXG1; JUN; NR2F6; EMX2; JUP; TOX; FOXO4; E2F2; ZNF586
Down-regulation 137 MYCBP; TCERG1; CCNA2; PARP1; MYC; GTF2A2; PCBD1; DRAP1; C1QBP; ADRB2; RBM14; RAN; ENO1; EDF1; SUB1; FHL2; HDAC2; NRIP1; NPM1; NUP62; SUV39H1; HMGA2; HLTF; FOSL1; DNAJC2; SMARCA4; BMI1; UBP1; CTR9; RUVBL2; EZH2; PPRC1; PRKDC; TBP; MED1; PMF1; MYBBP1A; SFPQ; BCLAF1; PA2G4; RBBP4; PITX1; YBX1; CBFB; TRIM28; TFAM; FLNA; MLX; RNF4; MTDH; ELK3; EGR1; SMARCE1; GABPB1; MTA1; MED24; TAF10; BATF3; BAZ1A; PTTG1; PIAS2; HMGB1; CRY1; HNRNPD; YWHAB; RHOA; HSF2; ZNF672; NCOA4; CARM1; GTF3A; TRIM32; RBBP7; NEDD8; BAZ1B; STAT1; POLR2A; KDM2A; ITGB3BP; GATAD2A; SND1; PUF60; CCDC59; HMGA1; TFDP1; ELK1; SF1; TRIM16; TP53; TRIP6; SMARCC1; FOXJ3; ETS2; TSC22D2; TEAD1; SREBF1; UBE2I; AATF; JARID2; HOXB7; DNMT3B; SMAD2; ZNF593; CTNNB1; NKX3-1; HOXC6; CEBPZ; CCNC; SSRP1; NELFB; ZBTB18; ZBTB38; HSBP1; RFX5; IKBKAP; BHLHE40; HES1; NCOR2; KLF10; IRX5; RNF6; NFIB; MAGED1; CBX3; PTRF; ING2; USP22; RBPMS; WWTR1; AFF1; NR2F2; ID1; BASP1; CRK; KDM5D; EGR3; SOX9