Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID12653 Ibrutinib GSE70138 HME1 Human 24h 1.11uM EID0038
Types Number Response transcription factors
Up-regulation 62 TSC22D3; NFIL3; NFE2L2; PCBD1; SMARCD2; NFKBIA; TP53; CEBPD; PFDN5; MEIS1; FOXO3; TRIM16; PHF20; CREG1; TCEA2; ERG; PNRC1; TOX; MTA1; HMGN3; SCAND1; TLE1; STAT3; AHR; TRIM22; ZBTB16; TRIP6; ID3; SOX17; ZSCAN31; PBXIP1; PIR; SSBP2; TRIM29; PBX1; HOXA5; EYA2; TCEB2; IRF6; SALL1; ATF3; ID1; IRF1; BACH2; MECOM; MYCN; LITAF; PEG3; MAF; ZNF91; SHOX2; ZIC1; ESR1; VGLL4; ARID5B; JUP; ZNF423; EMX2; IFI16; MEIS2; TXNIP; ARNT2
Down-regulation 27 HMGA2; CCNA2; FOSL1; BHLHE40; ETV1; TRIB3; EGR1; PPARG; BATF3; ETV4; SIM2; FOXM1; NPAS2; NKX2-1; ARNTL2; CREB3L1; FOS; HMGA1; BCL11B; IRF4; MYBL1; ZBTB18; EGR3; POU2AF1; KDM5D; ASCL1; NFATC3