Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID12398 Mitoxantrone GSE70138 HME1 Human 3h 10uM EID0018
Types Number Response transcription factors
Up-regulation 213 RFX5; LZTS1; EN1; ESRRG; BAZ1B; NR1D2; TXNIP; ZNF224; PRRX1; ZNF652; ZNF556; TFAP2B; ZNF528; GTF2I; SIM1; TWIST1; TRIP11; HIPK2; PPARGC1A; SIX5; SOX30; PML; MYF6; TBX1; EBF2; PAX9; ZKSCAN1; TEAD1; SATB1; CARF; ZNF253; ZNF287; CIITA; ESR2; RBBP5; CREB3L2; HAND2; MYCN; ZNF611; ARNT; SREBF2; PEG3; NR2F1; BARX2; HOXC10; CD3D; ZNF506; STAT1; HSF1; EHMT2; TRIP4; EMX2; BHLHE41; BRIP1; SNAI1; HOXB3; ZNF205; MYB; REPIN1; TTF2; MED12; TRRAP; RARG; ZKSCAN8; ARHGAP35; KMT5A; POU4F1; GATA3; GLI2; ZNF665; FEV; EPAS1; ZNF132; PHOX2A; SMAD5; GRHL2; BCOR; SP2; TAF1; MED24; EYA1; SP140L; ONECUT2; ZNF226; RBFOX2; NR2E1; MYOG; SPIB; TRIM24; ZEB1; ZNF667; ZFHX4; TMF1; PCBD1; ZIC1; NFATC3; TOX; TULP4; ZNF426; ZNF711; ZNF136; FOXI1; ZKSCAN7; MED14; EZH1; VGLL4; HOXC8; SKI; NCOA4; ZNF430; BRCA1; SOX9; RXRA; RHOA; RFX7; ZNF394; HOXC6; TBX2; AEBP1; PITX2; ZNF768; SPDEF; SND1; AES; ZNF124; MEOX2; TSC22D3; TOB1; HES1; EVX1; PROX1; PLAGL1; ZIC3; LMCD1; SATB2; ZNF551; ZNF835; PHOX2B; MEIS2; FOXD1; SIX2; BBX; TCEA2; HEY2; VPS72; MLXIP; HAND1; HDAC9; HLTF; BCL11A; RUNX1; GATA4; ZNF264; ZNF160; SOX3; ALX1; EGR1; NFAT5; ST18; YEATS4; ISL1; BARX1; MED1; CTNNB1; PITX1; ZNF721; TCF7L2; CAMTA1; ZFPM2; PAWR; MYCL; FOXE1; KLF2; EYA2; HLF; ID4; CBX7; SSX1; NR1H4; ZNF512B; ASCL1; ELF5; SMARCA2; IRX5; ZNF468; ZNF91; MAF; HEY1; BCL11B; SHOX2; IRF6; ARNTL2; ZBTB18; TCF7; TGFB1; GATA6; NCOA1; RBBP7; KLF9; FOXF1; SMARCA1; ZHX2; PAX6; ETV5; HMGN3; LEF1; CALR; HOXA10; ATF3; SOX11; TOX3; MSX1; POU2AF1
Down-regulation 130 MYC; NFKBIA; HMGA2; ADRB2; ZNF410; USP22; CEBPB; ZNF263; ZBTB11; SNW1; RNF138; NFKB1; TCERG1; FOSL1; FOXO3; GMNN; PA2G4; LPIN2; BCL10; SMAD3; ZBTB16; CRY1; CHD1; RNF4; PAXBP1; SFPQ; LOXL2; PPRC1; MED17; UBE2I; TRIM28; MAFF; RBM39; MED27; CCNA2; MAFG; RELB; FOS; CEBPD; HMGA1; CHD9; ERF; PHF1; HNRNPD; CBX5; ELF1; FOSB; VDR; ZNF324; PBX1; SMAD7; TGIF1; E2F3; RREB1; CTBP2; REST; ITGB3BP; HIPK1; RCOR1; MKL2; BAZ1A; ZNF189; RBBP8; TLE1; BASP1; ZBED1; BIRC2; TSC22D1; NRIP1; NFATC4; RYBP; NCOA6; FOXJ3; ELK3; VEZF1; JARID2; BCL6; NFIL3; SP3; CRYM; PBX3; BRD8; ZNF593; UBE2B; SP100; NAB1; NR4A3; ATF4; PFDN5; ENY2; STAT6; SIAH2; DEK; ZBED2; ERBB2; ZFP36L1; AFF1; YWHAB; ETS1; NKX3-1; TRIM32; ZMYND8; ERG; TCEB2; JUP; WT1; ESR1; ZNF266; FOXO1; CREBL2; MTF2; RBL2; CTR9; PHF20; MAFB; CREG1; PURA; SCAND1; IRF7; AHR; BRD4; KLF10; ZNF331; DEAF1; HHEX; TFAP2C; GATA2; THAP11; EGR2; TCFL5