Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID12259 Palbociclib GSE70138 HME1 Human 3h 0.12uM EID0018
Types Number Response transcription factors
Up-regulation 88 CEBPA; TRAK1; BCL10; GATA3; SMAD4; ZNF292; IRF6; ZNF516; ZEB2; DACH1; TTF2; HSF2; SIM1; MLLT10; PBRM1; BRWD1; ZBED4; TBX3; HHEX; CDK8; RUVBL2; GATA2; SREBF1; KAT8; MITF; TMF1; EGR3; OSR2; MYB; PLAG1; MTF2; NRBF2; TOX3; NR1H3; BCLAF1; E2F8; PAXBP1; SSX1; ILF2; ELF1; HIPK3; SMARCA2; BAZ2B; MBD2; HOXA10; LMCD1; ZIC1; ATF4; ID3; SOX9; TOPORS; MECOM; FOXC1; SMAD7; PBX1; NCOA1; KAT6B; MYCN; TRPS1; FOXA1; HDAC4; ID2; KLF4; MAF; JUP; ETS2; MNAT1; ID1; EGR2; CUX1; JUNB; BBX; STAT6; AHR; KLF9; NR2F2; DLX2; PAWR; BHLHE41; BMI1; EMX2; PEG3; HOXA11; ELK3; TCF4; BASP1; INSM1; ESR1
Down-regulation 65 ZNF611; COPS5; MXI1; CBX3; CD3D; CBX5; SSBP3; TCEA1; ZNF44; SP3; ZNF160; KAT2B; CTBP1; PRRX2; ZMYND8; ZBED2; MYT1L; SOX15; TBL1X; ERBB4; POU5F1B; ZNF721; AES; TCF7; AEBP1; WWC1; GATA1; ATN1; INSR; FOXF2; SATB1; PITX1; FOXF1; ZNF432; TGFB1; NFIC; ZNF544; CERS4; JUND; ZHX2; ZFP36L1; DEAF1; LIN28A; ZBTB18; ZBTB20; ELF3; PAX5; TAL1; POU2AF1; CARHSP1; STAT4; ZNF652; IFI16; THAP11; NR1H2; KDM5D; NANOG; WT1; TSC22D2; KLF10; HOXC6; TXNIP; ZNF586; MEIS2; TCFL5