Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11993 Fostamatinib GSE70138 HME1 Human 3h 0.12uM EID0017
Types Number Response transcription factors
Up-regulation 48 PAX8; TSC22D3; CENPF; CSDE1; SMAD6; TBX2; MECOM; ID4; NKX2-2; TXNIP; DNMT3B; ATF3; MITF; TEAD1; MDFI; POU5F1B; ID3; NR0B1; MEIS1; CTNNB1; ZNF165; TFDP2; ZNF665; WT1; RNF141; DDIT3; XBP1; NPM1; MSX1; CBX3; SALL1; ID1; KLF2; NFAT5; FOS; NR1H3; DMTF1; HOXA5; PURA; TSC22D1; HLTF; TBX3; RBPMS; PEG3; SATB1; KDM5D; SOX9; MXI1
Down-regulation 43 KAT2B; TRPS1; TLE4; WNT4; CBX4; MED21; JUN; THAP4; PHF20; MED17; CNOT3; TWIST1; SMAD7; CBFA2T3; EGR3; HIPK3; PBX2; CRYM; ADRB2; CITED2; FOXO3; BRD4; TGFB1; NR4A1; SOX11; SHOX2; JUP; FLNA; HTATIP2; RORA; ZIC1; ZFP36L1; KLF10; MNDA; HMGB3; GATA6; ZBTB16; EHF; POU2AF1; ESR1; KLF9; THAP11; ARNT2