Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11832 Afatinib GSE70138 HME1 Human 3h 0.04uM EID0016
Types Number Response transcription factors
Up-regulation 205 KDM5B; MEF2C; CEBPA; NFKB2; NR4A2; HDAC6; EN2; DLX4; POU2F1; ZNF711; THRB; ZBTB14; BRCA1; DNMT3B; MEOX2; CBX6; ZNF337; PURA; CIITA; RING1; ZNF43; GFI1; ARID4A; NR2C2; CBFA2T3; TXNIP; BATF3; USP21; CTBP1; TSC22D3; PITX2; ZNF85; KLF11; LHX6; CREM; SLC2A4RG; ZNF571; ELF2; LHX2; ESRRG; HCFC1; TAF6; ZNF536; SOX10; ZNF589; NR5A2; NFE2L3; HLX; HAND1; HOXC13; TBX2; MGA; ZNF253; FOXA1; ZBTB32; EBF2; EP400; ARID5B; RARG; MNX1; ZBTB7C; TLE2; MLLT10; WNT4; TCFL5; SETD2; ZBTB25; FLI1; EHMT2; NEUROD2; NHLH2; SETDB1; CRYM; NFAT5; ZNF529; BARX2; ZNF273; PIAS3; TRIM25; NR4A3; PCGF3; TLE4; BCL6; SREBF1; ZIC1; FOXF1; FOXN3; FHL5; RXRA; ZNF507; KDM5D; STAT3; ZBTB38; BCL11A; CHD1; FUBP1; NKX3-2; ZNF140; CUX1; ZNF33B; NR3C2; GRHL2; NEUROD1; WT1; RBM39; ARID4B; ZNF394; LEF1; HOXA1; CBX7; PRMT2; BANP; ZNF268; ZNF331; ZNF107; ATF7IP; MYF6; WHSC1; ALX1; ZNF14; IL16; ARRB1; ARID3A; SIX3; GTF2I; ZNF117; SP140; RFX5; PBXIP1; PPARG; HOXA11; GATA4; PAX6; BNC2; HMBOX1; HIC2; MECOM; KLF5; SKI; IRF7; SHOX2; FOXC1; MEIS1; RB1; RBPJ; CREB1; NFATC1; RHOA; WWTR1; ZMYND8; RORA; TCF4; NR1H4; CITED2; CHD9; PBX3; IRF4; CERS4; HOXC10; FOXD1; MLXIP; MTA1; HBP1; INSM1; HOXB2; ZFPM2; NR1D2; HTATIP2; KAT2B; BMI1; NR3C1; HOXA10; ID1; SERTAD2; PLAGL1; ZKSCAN1; IRX5; TEAD4; TFEC; MITF; ZIC3; DLX5; BACH2; SPEN; SOX13; TRPS1; ERG; HLTF; CUX2; HOXB7; PAX8; SMAD1; TWIST1; MYB; BTG1; NR2F1; SATB1; KLF9; LMCD1; CTBP2; TRIP6; DACH1; BASP1; GATA6; HMG20B
Down-regulation 101 FOSL1; SOX4; CEBPB; MED17; MAFF; SOX9; PPRC1; AGO2; CEBPE; MBD2; ECD; SREBF2; CIZ1; MYC; ZNF593; ZBED2; FOS; YAP1; SNW1; BTAF1; SMAD3; ZNF410; ZNF189; SSRP1; YWHAB; ETS2; CCNC; STAT1; GATAD2A; RNF111; IKBKAP; IFI16; DDIT3; DPF2; TAF1D; HMGA1; ARNTL2; TCF3; PEX2; KLF7; UBE2I; LOXL2; BIRC2; CD3D; TCF7L2; ERBB2; MAFB; MED14; HMGA2; PEG3; CALR; NKX2-1; GTF3A; E2F3; STAT5A; CCNH; ZFP36L1; DDX5; STAT6; TRIM16; VDR; BHLHE41; MTDH; BCL10; BAZ2B; TCF12; COPS5; RBBP8; PAWR; AHR; TSC22D1; RCOR1; NFE2; TCEA1; FOXO1; PRKDC; BAZ1A; TSC22D2; ENO1; TERF1; ZZZ3; PPP1R13L; ASCL1; LITAF; TCEB2; PHF20; ZNF232; SFPQ; TRIM22; BRD4; ETS1; SMARCA1; TOX; ESR1; TBX3; EYA2; HIRA; ELF3; POU2AF1; MNAT1; EGR1