Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11757 Fostamatinib GSE70138 HME1 Human 3h 10uM EID0016
Types Number Response transcription factors
Up-regulation 96 HES1; ID2; TSC22D3; EGR1; NFKBIA; CREBL2; HOXA5; JUND; XRCC6; NFIL3; HMGB1; ASH2L; RBPMS; TBX3; ATF3; CREM; RBL2; TOB1; PIR; DDIT3; ZMIZ2; THRA; GFI1; HLF; ENO1; DDX5; PURA; ARID5B; FOS; IKZF1; SOX10; BCOR; CBX5; KLF2; EGR2; SMARCA2; NR4A1; RAD21; SAP30; TP63; CERS4; JUP; CITED2; FOSB; HOXC4; NFE2L1; WWP1; ZNF160; NRBF2; PBXIP1; ELF5; DNMT3B; FOXF1; TOX3; NR5A2; ZBTB16; HOXB2; ZNF721; PITX1; HMGB2; KLF6; MXI1; TCF7L1; SATB1; TBL1X; LIN28A; GATA6; HOXC6; PNRC1; ERG; IRF4; ID3; MAGED1; CBX3; FOXJ3; ZMYND8; ZBTB20; BTG1; AFF1; INSM1; NFIB; KLF9; NR3C1; NR2F1; FOXC1; FOXG1; TOX; MYB; MAF; ID1; TXNIP; CREB1; ASCL1; MEIS1; PEG3; PBX1
Down-regulation 59 FOSL1; MYC; ADRB2; TCERG1; RELB; TRIB3; CHD7; EMX2; RELA; HMGA2; NFKB1; CCNE1; IRF1; DLX5; LEF1; BCL6; BACH1; MSX1; CHD1; PIAS3; NKX3-1; MAX; ZNF146; USP16; RREB1; ELK3; MED24; ZHX2; CREG1; BMI1; TSC22D2; KLF7; BACH2; ZNF512B; CRY1; AGO2; CEBPG; STAT1; SATB2; ZNF217; FOSL2; SOX17; CTNNB1; BAZ1A; IRF9; ESR1; SIAH2; MYRF; OSR2; NR2F2; TRIP6; WT1; MECOM; HOXA10; ETS1; BASP1; MAFB; TBX2; E2F2