Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11711 Withaferin-a GSE70138 HME1 Human 24h 3.33uM EID0015
Types Number Response transcription factors
Up-regulation 277 MYBL2; CEBPA; EGR1; AFF2; ZNF589; DAXX; CIITA; NFKB2; NR4A1; ASCL3; STAT2; SOHLH2; EGR3; ZNF835; PRDM14; KLF4; BCL11A; NR4A2; HOXC11; ZNF507; SOX5; GRHL2; SP4; ZNF816; NR6A1; ZNF695; DNAJC2; IRF8; ZIC3; ZNF331; PHOX2B; ZFPM2; CHD2; HOXB2; NFATC1; E2F2; SHOX; IKZF3; HESX1; POU2F3; POU6F1; PRDM2; TULP2; TLX2; MNDA; PRDM5; HMGXB3; CBFA2T3; SOX3; HIVEP3; NAB2; HOXC5; ZNF770; TEAD4; THRB; BNC2; PRDM9; TP63; ZNF154; ZNF557; TCFL5; PROP1; HHEX; ZBTB44; ZNF446; ZNF528; ZNF682; ZNF613; TCF4; ZNF215; POU4F2; ZNF444; SOX18; POU5F1B; ATF3; SSX7; MAML3; TUB; ZNF324; TAF4B; MEF2C; TBX1; FOSB; FOXH1; LIN28A; PRRX1; ZNF157; RFX3; PCGF2; THAP7; ZNF423; RORC; ELF4; ZNF814; KLF8; ZNF235; NUP62; NR1H2; ZNF266; TBR1; MED25; HOXC4; HNF4G; CIR1; ZNF623; HMX1; ARID3A; TSHZ2; BARX2; KLF15; ZNF415; TCEA2; ATF6B; AR; FOXE3; ZNF257; ID4; FOXI1; VENTX; SCAI; ZNF75D; MDFI; CDX1; TBX21; WT1; CNOT3; RARG; IRF6; TFAP2C; HOXD13; RUNX1; NANOG; E2F5; TLE4; JUNB; PRDM10; PAX4; FOXJ1; SAFB; CSDC2; ZNF580; DCC; ZNF506; LZTR1; ZNF571; SP140; TRIM22; ACTL6A; CBX4; CBX7; ZNF671; BCL6; PRDM12; CREB3L1; LHX6; NFE2L3; SOX11; SNAI1; CIC; BACH2; BNC1; LHX3; SSX1; TP73; ACTL6B; HOXB1; VGLL1; NR1H4; EMX1; ZNF771; TERF1; ZNF34; BHLHE41; POU6F2; ATOH1; MXD3; FOXE1; REL; BHLHE40; NFATC4; ZNF273; TRIM28; ZSCAN16; TAF6L; EVX1; VDR; INSR; SRY; MECP2; CREM; ETV4; HIC2; SPDEF; FOXJ2; APBB1; GATA3; ZNF131; TWIST1; SLC2A4RG; ZNF532; POU2AF1; ZFHX4; SKI; FOS; E2F4; AEBP1; ZNF304; CARHSP1; MAFG; BARX1; HLX; DACH1; SMARCD3; ZNF117; KLF11; MEOX2; ZNF350; EGR2; KLF2; IRF4; PBX1; HDAC9; SATB1; TCF7; ISL1; ERBB4; ZNF606; OSR2; HIRA; TRIB3; NR2F1; MEF2D; TRIM29; CRYM; ESR1; NR0B1; SALL2; DLX5; JAK2; KDM5D; PLAGL1; LDB1; HEY2; FOXA1; ZNF264; RXRA; MYB; GATA2; CERS4; EYA1; SHOX2; MAFB; TAL1; FOXO1; LMCD1; SOX17; HOXC10; ZNF226; CUX2; HMGA1; SOX13; TRIP6; ARNT2; MEIS2; ZNF512B; ID3; IRF9; TRPS1; FOXG1; ZHX2; LEF1; VPS72; MYRF; PBX3; JUP; SOX2; SOX9
Down-regulation 111 MYC; TCERG1; NR2F6; ETV1; NRIP1; RLF; RHOA; VEZF1; RB1; NFIL3; RNF10; NR3C1; HDAC6; DEK; CLOCK; MTDH; PREB; MYCN; BRD8; ATF1; RNF6; MYCBP; CENPF; COPS2; NFKB1; USP22; SMAD5; ZNF146; NCOA4; WHSC1; MED21; ENO1; ING3; CCNC; CDK8; ETS2; CRK; CHD7; XRCC6; TAF9; ZBTB18; C1D; ATF2; ZBTB1; PRKDC; CNBP; NFYB; SIX1; TBL1X; REST; NR1D2; CRY1; BAZ1A; LPIN2; ASCL1; TRAK1; TEAD1; TSC22D2; ZNF24; PEX2; WWC1; ARID4B; KLF9; PURA; BAZ2B; BBX; AFF1; TADA3; HMGB3; SUB1; TMF1; NPM1; SMAD3; STAT5B; CHD1; BMI1; BLM; TFAM; SFPQ; NCOA3; EDF1; MEF2A; RAD21; NFIB; FOXJ3; HSBP1; ADRB2; ZBTB11; ARNTL2; TOX3; MED1; ENY2; PTTG1; MED24; ZKSCAN1; CCNA2; SIX2; YAP1; NR2F2; ZNF12; JARID2; THAP11; CTR9; MSX1; AHR; TSC22D1; EYA2; ZIC1; ZBTB38; TLE1; BASP1