Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11628 Azd-5438 GSE70138 HME1 Human 24h 10uM EID0015
Types Number Response transcription factors
Up-regulation 582 EGR1; E2F2; ASCL3; AFF2; HES1; FOSB; RFX2; FOXJ1; BCL11A; ZIM2; ZNF816; PAX1; NR4A1; JUNB; SOX3; HNF1B; HAND1; ZNF507; FOS; ALX4; SSX7; ZNF611; TUB; LHX3; MAK; PBXIP1; HOXC8; RFX3; TFDP3; GBX1; HEYL; NOCT; BARX2; ESR2; CALCOCO1; HMGXB3; ZNF154; GLI2; ESRRB; PROP1; NR5A2; TBX6; THRB; NFIX; GRHL2; HIVEP3; MED31; POU6F1; ZSCAN18; ZNF589; NEUROD6; TBX19; NR6A1; ACTL6B; MXI1; PRDM14; ZNF562; AIRE; MAPK8IP1; HIF3A; ZIC4; E2F5; PRDM16; KLF15; MEIS2; ATN1; ZNF215; FOXE3; PDX1; HESX1; NEUROD2; ZNF536; ZNF667; HOXC5; CDX4; ZNF606; THRA; ATF3; ZNF711; MYCN; KMT2D; HES2; ZNF695; FOXD2; CARF; TLX1; ZNF331; RORB; NR1I3; ARID3B; MAP3K10; HOXB5; ZNF248; PRDM9; RBPJL; GLI1; CREBL2; SHOX; TBX10; ZNF177; PRDM5; SP4; FOXH1; HDAC11; WNT4; PAX7; RORC; HOXB8; HOXA6; HOXA3; DLX4; ZNF415; DCC; NKX3-2; ZBTB44; GRIP1; WDR77; ZFP2; ZNF221; IRF6; DLX6; ZNF426; ZNF701; POU3F4; ZNF506; DLX5; NHLH1; CSDE1; MED12; SRY; OVOL1; PRDM12; STAT2; ZSCAN2; WHSC1L1; NHLH2; NR4A2; PHOX2A; KDM5C; RFX1; ING4; CHD2; ETV3; ZNF358; SMAD6; ZNF768; KLF8; ONECUT1; AFF3; NEUROD4; EYA3; IKZF4; ZNF556; NKX6-1; TSHZ2; ZNF770; VSX1; ZNF471; VENTX; ZNF124; PAX2; PRDM2; ZNF639; NEUROG1; FOXL2; HNF4A; ZNF93; TAF6L; FEZF2; ATF7; UTF1; VGLL1; SOHLH2; HNF4G; CDX2; ZNF91; CIITA; NACA2; ZNF835; ZNF423; ZNF257; ZNF253; E2F1; HOXB13; ZNF264; HOXB1; FOXN1; ZNF749; ZNF778; SREBF2; ZNF665; ZNF688; ZNF117; ALX3; FOXL1; GATA6; CDX1; MZF1; ZNF440; PRDM1; ZFHX2; MTF1; NR1I2; NFE2L3; PITX2; MAML3; ERBB4; ZNF324B; HOXA2; HAND2; MED25; SSX3; POU3F3; KAT2B; TBX21; ZNF771; NR1H3; TBX4; GFI1B; LIN28A; CBX2; CBX7; NPAS1; NEUROG2; SOX21; TFDP2; ONECUT2; ZNF532; POU4F2; FOXP3; HOXA4; CUX2; CD3D; SCAI; ZNF710; ATOH1; NR0B2; ZNF345; TFAP2A; SOX17; ZIC3; SPIB; ZNF157; TULP2; PRRX2; ZNF550; ZNF239; TULP1; SIX3; THAP3; ZNF682; L3MBTL1; ZNF74; IKZF3; NR2E1; ZNF528; SCRT1; HIPK1; ZNF407; ZNF235; TLX3; IRF1; ZNF613; ZNF135; IKZF2; ZNF343; ZNF85; CSDC2; LZTR1; NR2F1; RARB; NR4A3; FOXA2; TEF; FOXD3; MAFK; SND1; SOX14; ZNF208; ZNF669; PHOX2B; CRX; MYF5; ZNF442; ZNF43; ELF3; PKNOX2; GCM2; ZNF549; SOX1; TFAP2B; POU6F2; ASCL2; TCF7; GBX2; LMX1B; RAX; SALL2; SOX5; FEV; TAF1C; ZNF671; NKX2-8; ZNF814; SSBP3; STAT5A; SIX6; ZNF112; NR5A1; NR3C2; HOXD12; TBX5; POU4F3; EBF2; ZNF223; PITX3; SMARCA4; PEG3; AR; ZNF81; TBX1; DACH1; ZNF674; ZNF391; ZNF350; POU1F1; SUV39H2; MSX2; PRDM8; ETV2; HDAC5; ZNF160; NFATC4; PCBD1; NEUROG3; KLF12; HOXB9; GATA1; PAX4; POU2F3; MXD4; PAX6; ZNF155; LMO1; ZKSCAN3; ST18; TAF6; ZNF254; VHL; POU3F2; ZNF219; EMX1; ZBTB7C; CBFA2T3; NRL; ZSCAN31; ZNF813; ZBTB7B; MYT1; HEY2; ZNF80; GSC2; FOXF1; TFAP4; ID3; HOXC13; LBX1; MDM2; SIX5; CRTC1; ZNF446; EVX1; HNF1A; ZNF132; ZNF362; TCF7L2; EGR3; MKL1; ZNF75D; ZNF107; ZNF675; DBP; LHX1; IFNB1; ZNF580; TAF1; ZNF780B; MBD4; TAL1; TAF7L; ZSCAN9; PRDM13; DOT1L; ZNF141; LHX6; HOXC11; ID4; EZH1; POU5F1B; FOXB1; SNAI1; RARG; ZFP37; DMRT1; NR1H4; HOXD13; DLX2; MYRF; HOXD3; TCEA2; MYF6; ZNF467; HOXB3; TLE2; SUPT4H1; HDAC9; ID2; ZBTB20; EP300; TTF2; SOX18; TEAD3; CIR1; HIPK2; ARRB1; RING1; CERS6; APBB1; SPI1; BNC2; CREM; IRF5; CDIP1; ZNF224; BATF3; PEX14; ZNF419; STAT4; NCOA2; EYA1; KLF3; CBFA2T2; PSMC3; PLAGL1; NANOG; MYCL; ZNF551; HSF4; TLX2; KLF1; LDB1; RBFOX2; ZNF44; THAP7; ARID3A; SMARCA1; OVOL2; PRRX1; TWIST1; RELB; BNC1; CREB3L2; MLLT1; NFAT5; TFCP2L1; ZNF500; CEBPE; SUPT5H; JUN; MEF2C; ZNF8; TP73; WT1; ZNF136; RERE; GATA4; ALX1; NOC2L; ZNF32; PAWR; ZBTB48; NR1H2; ZBED2; HBP1; ZNF33B; PBX1; FOXI1; RXRG; TRIM24; CERS4; FOXE1; EPAS1; BARX1; FOXN3; TCF21; MECP2; ZNF430; MEIS1; BHLHE41; TONSL; FUBP1; CAMTA2; ZNF175; JAK2; SOX11; ZNF273; ZFPM2; DYRK1B; MYOG; HEY1; ESR1; SP140; ELF5; EHMT2; CALR; HOXD1; PHIP; HIC2; NFKB2; VPS72; TCF3; NFIC; SOX10; HMGN3; EHF; SOX9; ZNF205; TOX; SUPT3H; INSM1; BACH2; ESRRG; SMARCB1; SRCAP; ISL1; INSR; ARID5B; ZNF721; TXNIP; CNOT3; BHLHE40; NR0B1; CEBPD; SUMO1; ID1; ZNF304; GATA2; LEF1; AEBP1; MEOX2; HLX; RXRA; SOX2; TGFB1; TFEC; ZNF195; TULP3; ETV5; KLF13; SATB2; CRYM; SOX13; WWTR1; ARNT2; HLF; TRPS1; BBX; PBX3; EGR2; IRF9; IRF8; THAP11; ZNF232; TOX3; CITED2; TCF4; MYBL1; ZNF586; CREB1; MYB; TBX2; NFATC3
Down-regulation 206 FOSL1; MYC; FHL2; CDK7; NFIL3; TBP; CCNA2; NFKBIA; NUP62; RBM14; TCERG1; BAZ1A; ECD; CTCF; EZH2; USP22; CBFB; CRY1; XBP1; ATF1; ADNP; TAF9; SNW1; RNF6; EED; NCOA6; DNAJC2; PATZ1; NFKB1; NKX3-1; TSC22D3; NACA; RAN; FOXO3; YWHAB; SMARCE1; KAT5; CCDC59; SOX4; RCOR1; CENPF; BRD3; CEBPB; NRIP1; NFYA; ZBTB11; BRCA1; REST; BRD8; ZMIZ1; NCOA4; ZBTB1; NPAT; DPF2; DEK; TAF4; KAT8; MED6; HNRNPD; BRPF1; MAFB; RNF111; ELF1; CNOT1; ZNF281; MLX; YBX3; TBPL1; BCL10; JARID2; ADRB2; TRIM29; HOXC6; PHF2; ZNF189; PPRC1; BTF3; MED17; ZNF410; CEBPG; SMAD3; MAML1; SFPQ; ZNF146; RARA; PUF60; NCOR2; SNIP1; ZFP64; ZNF263; HOXA5; PA2G4; MNT; TLE1; MBD2; TRIM32; ARID4B; RBM39; TAF5; MEF2A; CRK; NR2C1; VEZF1; DR1; GMEB2; BAZ1B; NPM1; RNF138; RREB1; SNAI2; DDX17; KLF9; ASXL1; CEBPZ; C1D; PHF20; TMF1; TRIM27; ETV1; SF1; NR2F6; HMGB2; APEX1; UBP1; RNF4; RBBP4; SMARCA5; ELK3; BRD7; NELFB; HMGB1; MAX; NAB1; ING2; ARNTL; FOXM1; BCLAF1; MAF; BCOR; AATF; RRN3; SMAD7; TFAP2C; RYBP; PTTG1; MED1; DNAJC1; KDM2A; NFE2L1; CTR9; CARM1; HOXB7; KAT7; ERCC3; ZMYM2; PCGF2; SCAND1; SP110; IRF7; SIRT7; NONO; FOXD1; IFI16; IRF2; FOSL2; ZNF302; ASH2L; SETD2; AHR; NRBF2; MED24; SERTAD2; KLF2; MED21; SREBF1; BIRC2; BLM; RUVBL2; SUV39H1; MEN1; RBL2; SMAD1; BACH1; NCOA3; CHD7; ZNF217; LOXL2; BMI1; TGIF1; CHD1; TLE4; RBBP8; TFAM; TCF12; TSC22D2; NR2F2; KDM5D; AFF1; ZNF12; TRIP6; MITF; SAP30; HMGB3; RBPJ; ZBTB16; ZNF512B