Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11602 Afatinib GSE70138 HME1 Human 24h 3.33uM EID0015
Types Number Response transcription factors
Up-regulation 87 ZNF274; NFKBIA; MNAT1; ERG; FOXO4; TP53; ZSCAN18; ZSCAN31; WWC1; PPP1R13L; CREG1; IRF1; TSC22D3; NR1H4; TAF7; PRMT2; TLE2; PNRC1; ZNF419; ZNF140; TFEC; PBXIP1; CEBPD; JUP; TOX; BHLHE41; DNMT3B; DACH1; HMGN3; TRIM29; ZNF219; PHIP; ZBTB20; ELF3; LYL1; FOXF2; ING4; POU5F1B; MED23; ATF3; ZNF165; ZNF544; MTF2; ZNF224; TRIM16; DMTF1; IRF6; GRHL2; ST18; ZNF84; NKX2-1; PTRF; BCL11A; ZNF304; ZNF721; ZBED2; FOXF1; CTBP2; KLF1; EPAS1; NR1H2; MITF; SMARCD3; ZNF160; ETS2; RBBP8; TP63; EHF; TLE4; TCF21; RBPMS; SALL2; HDAC9; HOXD1; DDIT3; TRIM22; PBX1; PAX6; ZNF532; MYCL; TRIB3; INSM1; TXNIP; EMX2; ERBB4; ARNT2; ESR1
Down-regulation 26 EGR1; FOSL1; MYCBP; CBFB; BAZ1A; XRCC6; EGR3; PLAG1; HMGA2; MAGED1; ZFP36L1; ING3; SPIB; HMGA1; FOXD1; BHLHE40; MSX1; JUNB; THAP11; BMI1; NRIP1; PAX5; HOXB7; ZBTB18; TWIST1; ID1