Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11504 Alvocidib GSE70138 HME1 Human 24h 1.11uM EID0015
Types Number Response transcription factors
Up-regulation 582 EGR1; AFF2; ASCL3; SSX7; LHX3; ZNF816; NEUROD4; PAX8; ZNF711; CHD2; ZNF154; GBX1; NR4A1; CARF; PAX1; SOHLH2; HOXC11; SRY; ALX4; MED31; IKZF3; GLI2; ZBED2; ZNF536; TFAP2A; ZNF695; ATF3; PRDM14; TUB; HESX1; STAT2; THRB; HOXC5; HOXA2; HOXD3; TFDP3; SOX3; CEBPD; CIITA; PAX7; SSX3; MEIS2; SP4; HNF4A; MAML3; TCEA2; ZNF507; FOXE3; ZNF223; NR6A1; ZNF835; HOXB8; HAND1; NHLH2; RFX3; NEUROD1; ZNF701; VGLL1; VENTX; MED12; FEZF2; ZIM2; HNF1B; ASH1L; PRDM9; TULP2; RFX1; PDX1; ZIC4; TBX21; ZKSCAN8; ZNF221; NEUROD6; RORC; ZNF287; NEUROG2; SIX6; NFIX; NR5A2; DLX5; ZNF611; GRIP1; SOX21; TBR1; NEUROD2; TEF; ZIC3; NR1H4; MECP2; NR2E1; ZFP2; SHOX; DCC; CBX2; BCL11A; AFF3; IKZF2; ZNF471; PROP1; MAPK8IP1; GCM1; ESR2; HHEX; SCRT1; ZNF75D; ARID3A; PRDM1; CALCOCO1; ZNF467; CDX4; WHSC1L1; ZNF442; RBPJL; ZNF117; ZNF780B; GCM2; ZNF440; SOX5; KLF15; LHX6; HEYL; ZBTB44; FOXJ1; MED25; POU2F3; ZFPM2; SSX1; KDM5C; DLX4; HIPK2; ZNF257; HES2; PHOX2A; NEUROG1; POU3F3; TBX5; LMO1; ONECUT1; NOCT; SCAI; POU1F1; EBF2; PAX3; ZNF407; NR1I3; PAX4; TAF7L; BRDT; ZNF682; ZNF674; POU3F2; THAP9; ZNF264; ZNF80; ZNF157; HDAC5; POU6F2; HAND2; EHMT2; ZNF556; NFATC4; ZNF345; ZNF391; NKX2-5; PRDM16; HOXC8; PHOX2B; HOXB1; ZNF778; TULP1; FOXD2; TBL1Y; CRTC1; SPI1; ATF7; RFX2; HOXD12; MXD4; ETV3; KMT2D; ESRRB; ZNF415; TAF1; UTF1; SOX14; ACTL6B; ZNF493; ATN1; ZNF81; PRDM5; ZNF814; CBL; ALX3; TBX4; ZNF749; RORB; ZSCAN2; FOXD3; ZNF174; TBX19; ZNF331; ZNF273; FOS; ZNF208; SPIB; HDAC9; FOXL1; HOXA4; LBX1; TLX2; SOX1; ZNF510; E2F1; HIF3A; EMX1; VPS72; DOT1L; ASCL2; IRF1; ZNF549; HOXA6; GSC2; SOX17; RING1; ZNF589; HSF4; HDAC11; NFKB2; TFAP2B; HNF4G; PAX6; ZNF91; ZBTB17; ZBTB7B; FOXH1; POU3F4; CUX2; TSHZ2; AIRE; DMRT1; ZNF550; NFIC; SNAI1; ZNF253; ATOH1; ZNF667; POU4F2; MSX2; FOXB1; GFI1B; ZNF254; IFNB1; ZNF671; VHL; CRX; ARID3B; ZNF492; POU6F1; SIX3; ZNF235; HIVEP3; GATA1; HNF1A; ZNF770; TAF6L; NRL; ONECUT2; SUV39H1; HOXD13; ZNF41; ZNF214; DBP; ZNF225; AR; PITX3; ZSCAN9; DLX6; HOXD1; KLF8; TP73; NPAS1; NACA2; TFDP2; OVOL1; RARB; RAX; SOX18; HOXA3; HOXB13; AES; NFKBIB; PPARD; CSDC2; ZNF675; TLX1; RFXAP; ESRRG; NEUROG3; FHL5; ZNF362; TAF1C; ST18; POU4F3; FOXC2; MYF5; EZH1; ATF6B; TLX3; HOXB5; MLLT1; IRF6; ETV2; ZSCAN18; ZNF350; ZXDB; BNC1; NHLH1; ZBED1; CREM; ZNF141; ZNF710; ERBB4; NR0B2; TBX6; ZNF248; HINFP; ZNF136; EN2; PROX1; ZXDC; ZNF215; CDIP1; SIM1; FOXE1; ZNF423; CBX7; FOXP3; TWIST1; ZBTB32; HIC1; MKL1; TAF6; GBX2; ZNF500; CAMTA2; MECOM; FOXL2; L3MBTL1; FOXN1; MYEF2; ZFP69B; FOXI1; PEX2; CREBL2; RARG; PRDM13; NR5A1; RBFOX2; PRDM2; PKNOX2; ZNF688; PGR; OVOL2; TFAP4; ID4; NKX6-1; BNC2; JUNB; NKX3-2; WNT4; MAK; HBP1; JUP; ZNF665; NFE2L3; SUPT3H; FOXO4; SP140; ZKSCAN3; MYBL2; PAX2; LIN28A; SPDEF; SUPT5H; NR4A2; ELK4; MAP3K10; ZNF85; ZNF768; ZNF33B; PRDM12; NR1H3; MEIS1; VAX2; NR2F1; ZNF506; LHX2; ZNF606; MYRF; E2F4; BARX1; ZNF74; LMX1B; ZFP37; IRF5; ZNF771; IRF3; POU2F1; FOXG1; CDX1; KLF13; MZF1; TBX10; KAT2B; FOXA2; SUPT6H; LZTR1; CREG1; BHLHE40; BACH2; FOXF2; CALR; ZNF177; ARRB1; TTF2; E2F2; YBX2; CNOT3; ZFHX4; TFEC; WT1; CNBP; GRHL2; ZNF44; ZFHX3; MYT1; MDM2; MNDA; ESR1; HMGN3; TCF21; HLF; SMARCA1; CEBPE; MAFK; HOXC4; CD3D; SALL2; DYRK1B; PBXIP1; PEG3; ELF3; TBX1; MXD3; NR4A3; HIRA; TCF4; NKX2-2; EHMT1; ING4; RSF1; SMAD6; CBFA2T3; STAT4; ZNF205; ZNF219; EMX2; IRF9; HOXC13; SETDB1; SNAPC4; TXNIP; NR0B1; INSM1; ID3; ZNF654; PBX1; MYT1L; PLAGL1; CSDE1; SKIL; PBX2; ZNF107; SCMH1; SMAD5; TFEB; ZNF419; SIX5; SSBP3; E4F1; MEOX2; PFDN5; PITX2; IRF8; SRCAP; PNRC1; EGR2; SOX2; PCGF3; TLE2; WDR77; KLF3; ZNF43; EYA1; CERS4; ZNF124; FOXF1; CBFA2T2; TGIF2; POU2F2; RXRG; GATA6; NFE2; CBX4; ZNF532; FOSB; MYCN; HOXD11; CIC; ZNF224; MED14; AEBP1; RCOR3; PLAG1; NR1H2; WWC1; MNX1; REL; BCL6; ZNF580; DLX2; PBX3; E2F5; NOC2L; NFAT5; ISL1; THRA; RERE; PITX1; ZNF93; ZBTB20; PRRX1; CAMTA1; EPAS1; EN1; ZNF304; EP300; ZNF160; TRIB3; HEY1; MEF2C; ZNF195; MEOX1; SHOX2; BCL3; JUN; MXI1; CITED1; GATA2; HIC2; TGFB1; SOX13; TAL1; NANOG; HLX; CREB3L2; ZNF232; ARNT2; ZNF652; TRPS1; MYBL1; MYCL; DACH1; CREB1; ZEB1; ZIC1; NFATC3; LEF1; ZNF586; ID1; TBX2; IKZF1
Down-regulation 214 FOSL1; FHL2; NFKBIA; MYC; USP22; EZH2; NFIL3; TCERG1; CCNA2; NUP62; XBP1; FOXO3; CDK7; MED6; TBP; SNW1; PPRC1; RBM14; ADNP; CNOT1; CEBPB; ADRB2; SOX4; BRCA1; ZBTB11; MED1; CRY1; ECD; CCDC59; PURA; AATF; DNAJC2; KAT6A; YWHAB; ZFP36L2; ZNF146; RYBP; NFKB1; SMAD3; NPAT; NKX3-1; BAZ1A; KAT7; BTG1; SFPQ; ELK3; PCGF2; PATZ1; RNF111; RNF6; TSC22D3; MLX; TBPL1; RLF; CTCF; UBP1; RCOR1; RBBP4; E2F3; ATF1; CBFB; HOXC6; RREB1; CENPF; RAN; GABPB1; RRN3; SSRP1; HSF2; SNIP1; ELF1; BCL10; FOXJ3; DDX5; RNF138; DR1; TERF2; FOXD1; BRD8; PRKDC; MED23; NCOA6; TRIM32; TAF4; NEDD8; PSPC1; MTDH; PUF60; RBM39; TAF9; NRBF2; ZNF266; CDK8; CEBPG; CRK; NFE2L1; BRPF1; TRIM27; EED; POLR3F; VEZF1; ZBTB18; TBL1XR1; THAP1; ZNF281; TSC22D2; ZBTB7A; KAT8; TOB1; LOXL2; TRIP6; NPM1; CEBPZ; REST; DDX54; C1D; HNRNPD; BCLAF1; ZNF263; AFF1; JARID2; KLF10; CHD1; UBE2I; TMF1; CNOT6; ZBTB1; APEX1; NFYB; BAZ1B; AGO2; ZNF189; CTBP2; HOXB7; DAXX; SMARCE1; TCF12; BRD2; KDM2A; ZZZ3; ZNF473; BASP1; NCOA4; SF1; TRIM28; DNMT3B; DEK; ARID4B; SMAD1; ZNF302; ABL1; ZMYM2; AHR; RNF4; IRX5; NRIP1; HDAC1; TRIM29; ZNF12; MBD2; HDAC7; SCAND1; BTAF1; HMGB3; BATF; UBE2B; PTTG1; COPS5; CARM1; ING2; ASH2L; SNAI2; KLF6; RUNX3; PLAGL2; TP63; CENPB; ATF4; TOPORS; VGLL4; HMGA1; ARNTL; CTR9; MED17; BIRC2; ZBTB16; HSBP1; SMARCA2; ELF5; BLM; PHF20; ETS2; HOXA5; MED24; BMI1; TRIM16; NAB1; FOSL2; MAFB; EYA2; HMGB2; TLE1; SAP30; MYB; FOXC1; KLF2; MAGED1; MED21; BCL11B; SIAH2; TFAP2C; ZBTB38; TLE4; RBPJ