Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11321 Saracatinib GSE70138 HME1 Human 24h 0.04uM EID0014
Types Number Response transcription factors
Up-regulation 92 SIM2; EGR3; HSF1; GTF2I; NPAS2; EGR1; SMARCC2; SAP18; ZNF768; TFAP2C; ZNF33B; ZNF248; RBL2; RFX5; HOXA10; RUNX3; AFF1; SOX9; THRA; LHX6; TBX2; FOXE1; EDF1; MAF; TRIM33; MBD2; SPDEF; NCOA6; HDAC9; KLF4; SREBF2; BRD7; ZBTB16; KDM5D; RUNX1; ZNF84; LIMD1; PATZ1; JUN; ELF1; SATB2; ARID5B; JAK2; NFE2L3; SMARCA2; FOXA2; EMX2; TP63; IL16; BATF; NKX2-1; HDAC1; DDX17; ETS2; FOSB; ZNF165; CREM; NR4A1; ATF3; DNAJC1; NR4A2; KLF11; CSDE1; ZNF354A; MNDA; NFATC1; E2F3; ZNF274; GRHL2; ADRB2; NR2F1; CBX6; FOXD1; TRIM29; HOXA11; DACH1; LMCD1; BMI1; IRF6; OSR2; KLF2; NCOA3; BHLHE41; ZNF331; NKX3-1; FOXC1; CREB1; MYB; HOXC6; MEIS1; TOX3; ID4
Down-regulation 72 DNMT3B; ATF2; ZMIZ1; DDIT3; LIN28A; HDAC5; ZEB1; ACTL6A; SIRT7; RUVBL2; RARB; NOC2L; ZNF263; RLF; LITAF; KAT2B; GCFC2; MSC; ZNF468; PSIP1; COPS5; MYBL1; HOXB2; PIAS4; ARNTL2; PTRF; MEF2A; NR2F6; LOXL2; WWTR1; NPAT; ZNF232; NUP62; GATA6; ID3; BIRC2; HBP1; CRY1; BAZ2B; TDP2; SP3; HMGB2; ZFHX4; TGFB1I1; BATF3; TERF1; SMARCA1; SPEN; NFIB; SMAD1; TAL1; ID1; MEIS2; ZNF665; CREG1; CUX2; ZNF611; MSX1; NAB1; SOX10; HIRA; CITED2; SCAND1; ZNF43; TRIB3; NANOG; SOX11; ZFP36L1; ZNF91; MEOX2; PBX1; SATB1