Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID11277 Alvocidib GSE70138 HME1 Human 24h 1.11uM EID0014
Types Number Response transcription factors
Up-regulation 647 SUV39H1; EGR1; PRDM2; RBPJL; ZNF816; KDM5B; NFIX; ZNF536; RFX1; GATA2; PRDM16; LZTR1; MYCN; AFF2; SOX17; FOXH1; TFDP3; STAT2; CDX4; THRB; ZFHX2; ALX4; VENTX; PCBD1; WNT4; GFI1; HOXB1; TUB; NR1I3; FOXP3; ARID3B; TAF6L; NFKB2; ESR2; ZBTB44; CRX; ARRB1; SSX7; MED12; NKX6-1; PAX1; MAP3K10; PRDM12; TBX6; EBF2; HIC1; NR5A2; ZNF142; KMT2D; ZNF136; TAF1C; TULP1; MYT1; ASH1L; ZNF215; ZNF639; ZNF778; HAND1; NPAS1; HOXC8; SCAI; GRIP1; PAX2; ZIM2; RSF1; ZNF154; ZNF257; ASCL3; TFEC; ZNF771; ZSCAN2; TLX1; ONECUT1; ZNF221; ZNF93; NOCT; EYA3; FOSB; NR2C2; PBX3; POU3F4; PRDM9; AIRE; ZBTB48; ZNF273; ZBTB7B; FOXL1; HDAC6; E2F1; ACTL6B; DYRK1B; NEUROG1; LHX3; RFX3; ZNF507; ZNF35; TFDP2; HIF3A; ZNF710; WHSC1L1; VAX2; KLF15; HOXA6; ZNF74; MED31; NR5A1; AR; HNF1B; PAX8; ZNF423; HAND2; EMX1; ESRRB; HNF4A; ZNF669; HES2; STAT4; SIX5; MAML3; ZNF124; ZNF500; PROP1; GTF2A1; TAF1; FOS; FOXE3; PEG3; FOXO4; PITX2; ZNF362; LMX1B; FOXB1; DLX6; ETV2; DLX4; CALCOCO1; TRIM25; NR6A1; BRF2; CCNE1; PHOX2B; RFXAP; SOX18; NEUROD4; IKZF2; SSBP3; L3MBTL1; LMO1; POU4F2; ZNF180; NEUROG2; MLLT1; NR1H2; SOX1; ZBTB39; HIVEP3; HOXA4; RORB; IFNB1; NACA2; ONECUT2; ZNF174; MAPK8IP1; RAX; GBX2; ZKSCAN4; TBR1; SRY; ZNF749; MYCL; EHMT1; HOXB8; ZNF467; ZIC4; HOXB3; SOX14; ETV3; SHOX; AFF3; ZNF253; HOXC5; FEV; HOXD12; APBB1; CHD2; PAX3; FOXD2; SCRT1; PHOX2A; POU4F3; ZNF224; MEF2C; CBX2; ZNF208; ZNF768; ZFHX3; LDB1; FOXN1; NEUROD1; MDM2; SSX3; IKZF3; RORC; ATF7; ZBTB32; JUN; ZSCAN9; MYNN; ALX3; SP4; GBX1; CREM; HEYL; HOXB13; ERBB4; LHX1; CARF; ZNF442; PRDM14; PAX7; FOXD3; GMEB1; NHLH2; TLX3; IKZF4; ZNF550; PDX1; SOX3; ZNF770; FOXC2; FEZF2; ZBTB7C; ST18; ZNF444; MZF1; DOT1L; ATF6B; POU6F2; LHX6; ZNF75D; TBX4; MKL2; GCM1; TBX5; SIX3; TFAP4; CBX8; INSM1; TLX2; NR0B2; ZNF264; E2F5; SP140; HIPK2; ZNF91; TGIF2; UTF1; ZNF835; DCC; EVX1; NEUROG3; ZNF358; PRDM1; SMAD6; SETDB1; ZNF671; NR2F1; TBL1Y; EHMT2; ZNF611; TBX19; ZNF248; ZNF701; ZNF3; ZNF580; ISL1; POU2F1; SNAPC4; MNX1; ZNF695; HCFC1; NKX2-1; HDAC11; ZNF286A; NEUROD2; MYT1L; NKX2-8; ZIC3; KLF12; ZNF440; ZNF556; ZNF688; TFE3; SIX6; TDP2; NRL; ZBTB3; E2F4; LBX1; ZNF157; HNF1A; RFX2; ZNF780B; MEOX1; POU2F2; MYEF2; ZNF222; IRF5; HOXB5; PITX3; HOXD13; ZKSCAN8; ATOH1; POU6F1; ZNF510; TAF5; ZNF484; ZNF14; JUNB; TULP2; NR2E1; HDAC5; ZNF814; SUPT5H; TCF21; TAF4B; HMBOX1; NHLH1; ZNF239; ZNF549; ZNF205; PHF8; ZNF606; ETV5; DMRT1; ZNF250; WT1; SOX21; HESX1; FOXE1; MAFK; ZBTB14; ARHGAP35; ZSCAN32; ZNF225; PRDM5; POU2F3; POU5F1B; ZNF195; GCM2; CRTC1; SKIL; ZNF492; MTF1; ZNF528; ESR1; ZNF506; ZNF80; ZNF471; ZNF223; FOXN2; EPAS1; TEF; SALL2; ZNF81; ZFPM2; ZBTB24; CHD3; POU1F1; CSDC2; RBBP5; HDAC9; TONSL; TCEA2; TBX10; ZSCAN31; GATA1; RARB; ZNF33B; EGR4; STAT5B; ZNF682; ZNF235; TLE2; ZNF331; POU3F3; TAF5L; NEUROD6; THRA; ZNF646; ZKSCAN3; OVOL1; ZNF613; TP73; PRDM10; VGLL1; SOX12; NFKBIB; MBD3; HOXA3; RARG; MDM4; NR1H3; REL; FOXA2; NFE2L2; RORA; EZH1; ZNF85; NANOG; CDX2; MEIS2; ZNF415; ZFP69B; SNAI1; GFI1B; RXRG; TFAP2B; ZNF675; KDM5C; KDM4A; SPDEF; ZNF43; MEIS1; STAT5A; ZNF155; ZNF8; MED25; ZNF132; CD3D; EN2; RELB; BNC2; HIVEP1; NR4A1; NFE2L3; MAK; RCOR3; SREBF2; BARX1; PAX4; EP400; TGFB1; ZNF254; ZNF696; SOX13; CRYM; PRRX1; HLF; TEAD3; ZNF764; CEBPA; FOXJ1; CBFA2T3; HBP1; ZNF350; KLF8; TDRD3; MXI1; CIITA; ZNF76; ZNF552; IRF1; LIN28A; OVOL2; POU3F1; SOX11; MKL1; HNF4G; SPEN; IL16; PIAS3; IKZF1; BCL11A; ZNF787; SKI; GLI2; LHX2; SOX5; HIC2; PKNOX2; ATN1; INSR; ELK4; MED16; TERF1; PEX14; CDIP1; MBD4; CBL; BRDT; ZMIZ2; ZXDC; ZBTB25; SPIB; ELK1; CIC; NR1H4; MLLT10; CNOT3; ZNF532; ZSCAN16; ZNF493; BRWD1; ZNF711; BACH2; ZNF667; ZNF629; CEBPE; ZNF287; CCNT1; ASCL1; ZKSCAN7; ZNF557; PIAS1; HLX; SPI1; CCNC; MYBBP1A; GLI1; ARID1A; HOXD3; ZNF529; IRF9; FHL5; KAT2B; NR4A2; NFYC; ZNF562; SOX2; ZNF117; NAB2; TAF6; NFIC; ZNF345; E2F8; SIN3B; ZNF44; IRF4; LZTS1; ZNF623; PBXIP1; ZNF813; TCF3; ZNF587; TRIM33; IRF8; CSDE1; FUBP1; CREB3L2; ZNF141; RERE; FOXJ3; ZNF430; ZNF24; MECP2; ZNF652; FOXN3; OLIG2; YEATS4; AES; ZNF165; EMX2; ZNF219; KLF13; ZSCAN18; GRHL2; TTF2; ZNF589; SUPT6H; NR1I2; ZNF160; SMARCD3; HHEX; ARID4A; CUX2; ZNF135; ZNF148; ING4; CDX1; SND1; ZNF107; KLF3; ZNF22; HOXD1; NLK; PLAGL1; CREBL2; ARL2BP; TCF7L2; MAZ; NR3C2; NKX2-2; ZNF544; LITAF; NFAT5; CREBZF; ZNF721; JUND; SHOX2; HOXD11; SIX2; CAMTA1; YBX2; HEY2; SMARCA1; ID2; SSX1; ID3; ZBED2; TP53; VPS72; ZNF354A; TCF4; SMAD7; ZFHX4; TFAP2A; KLF4; GATA6; TCF7L1; ZNF304; ZNF573; PAX6; ZNF665; POU2AF1; MEOX2; DLX5; TAL1; E2F2; FOXF1; ZIC1; DACH1; EGR3; ZNF329; IRF6; HMGN3; NFIB; PBX1; MYRF; CITED2; HOXA10; CREB1; TBX2; TCF7; ZBTB18; ARNT2; ZNF586
Down-regulation 210 FOSL1; MYC; YBX3; FHL2; CDK7; TSC22D3; CEBPB; SSRP1; FOXD1; MEF2A; CCNA2; USP22; CNOT1; TP63; MED1; RBM39; ELK3; TRIM29; DR1; SNW1; DDIT3; ZNF266; ADNP; RBBP7; SMARCA2; NCOA6; PTTG1; HNRNPD; HMGB2; NRIP1; TOB1; ATF4; VEZF1; DNAJC2; HMGA2; RNF4; CDK2; MED17; TLE1; RUVBL1; EED; PSMC3IP; SMAD3; SAP30; KLF9; TBP; KLF5; PMS1; DPF2; ZNF473; RBM14; CENPF; RUVBL2; GABPB1; RNF6; RCOR1; TCF12; MAFF; RUNX1; NAB1; RREB1; IFI16; MED6; MNT; ITGB3BP; CCDC59; CTBP1; VGLL4; ELF1; ATF1; EWSR1; ZBTB11; UBE2I; ZMIZ1; RFC1; MBD2; TAF4; HDAC4; MLXIP; ZNF189; BTG1; ARNTL2; NFIL3; TRIP6; PUF60; ERCC3; CTCF; ZMYND8; SOX9; HOXC6; MITF; ZNF263; ZFP36L2; CRK; CHD1; CBFB; WHSC1; PLAGL2; SMARCE1; UBP1; CRY1; SLC2A4RG; TRIM28; BRCA1; BRPF1; ADRB2; ABT1; TMF1; RARA; DEK; NR2F6; SIRT7; ZBTB7A; ZNF302; YWHAB; MED21; TAF9B; BRD7; BCLAF1; NFKB1; NCOR2; SNAI2; BCL10; ZBTB38; SALL1; SFPQ; XRCC6; PCGF1; ING2; ERBB2; TAF9; CLOCK; ZBED4; MED23; AATF; LOXL2; C1D; NEDD8; RFXANK; ZNF217; ARID4B; KAT8; SMARCA5; CEBPZ; SCAND1; ZMYM2; APEX1; ATF5; TBL1X; CBX3; PSPC1; ZNF12; ZNF83; WWC1; FOXO3; FOXO1; ZNF146; NUP62; SETD2; SMARCC1; PMF1; ZFP36L1; NR3C1; TRIM32; ARNTL; NRBF2; PSIP1; SREBF1; TLE4; MAF; WWTR1; PRPF6; HOXB7; CEBPG; RBBP4; ZNF274; MAFB; TEAD4; FOXF2; HSF2; EHF; TBL1XR1; AHR; FOSL2; TCEB2; ZBTB1; RNF138; NCOA3; NKX3-1; NFE2L1; CNOT6; SMAD1; HMGB1; ENO1; ARID5B; IKBKAP; ID1; HOXB2; FOXC1; MTF2; BASP1; PCGF2; KLF10; ZEB1; MNAT1; CTBP2; SSBP2; TOX3; THAP11; LEF1