Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09797 Withaferin-a GSE70138 HA1E Human 24h 3.33uM EID0003
Types Number Response transcription factors
Up-regulation 555 EGR1; CEBPD; FOS; SPDEF; CBFA2T3; ZNF154; ZNF195; CUX2; TRIB3; ZNF235; ZNF10; ZNF232; VPS72; SIX6; ZNF273; ID2; SCAI; ZNF557; TCF7L2; ZNF141; CBX4; E2F4; ZNF225; ZNF75D; ATF3; ZSCAN9; ZXDB; FEZF2; CDX1; HINFP; CHD2; NR4A1; TP73; MAML3; EN1; ZBTB3; KLF11; ZNF345; HDAC9; LHX3; ZKSCAN8; PRDM14; ZNF695; ZSCAN32; ZNF74; ZFP69B; DDIT3; MED17; SRY; ZNF573; ZXDC; SP4; SOX18; KDM5C; ZNF155; PRDM10; ZNF682; ZNF180; RFX3; ZKSCAN4; CCNH; THRB; NR1H4; ZNF214; TAF4B; ZNF835; HESX1; TCEA2; ONECUT1; ZNF770; ZNF221; POU1F1; ASCL3; ZNF81; TBX4; THAP9; GBX1; CARF; ZNF287; ID3; MEF2C; REL; ZNF814; TSHZ2; TBR1; NEUROG3; ZNF391; ZNF343; ZNF304; TRIP11; POU4F3; ZNF780B; PRDM9; PCGF1; TFAP2A; RORB; ZNF8; CREM; HIF3A; NEUROD4; MEIS2; IRF6; RFX1; ZNF675; NR4A3; ZNF223; SALL2; ZNF778; DOT1L; E4F1; RORC; ZNF407; ZNF471; HIPK2; CNOT3; TAF1C; THAP7; ZNF264; ZNF549; ZNF701; FOXH1; ZNF253; ZNF816; ZBTB44; HOXB1; ZNF550; HIC2; TLX3; PNRC1; ZNF415; TBX19; ZNF674; FOXB1; SOX13; KLF4; MYEF2; ING4; ZNF442; ZNF222; PAX4; ZNF423; ZNF117; MAK; NEUROD6; ZNF480; ZNF500; ALX4; CBX2; POU6F2; ZNF711; MXD1; TEF; RBPJL; ST18; ZNF254; SMARCB1; ZNF85; CD3D; NEUROG2; ZNF274; BRDT; ZNF80; ZNF507; SCRT1; NFATC4; EMX1; ZNF227; VENTX; ZNF331; ZBTB6; ZNF174; ATF7; ZNF239; PRDM13; ZIC3; TULP1; BRWD1; MYCL; PROP1; HSF4; ZNF484; TULP2; BCL11A; BARX1; ZNF234; VGLL1; ZNF749; NHLH2; ATOH1; IKZF2; ZBED2; SOX14; CIITA; ZNF132; HOXD13; RFXAP; SETDB1; TLX2; ZNF362; ZNF394; ZNF124; ZNF91; SOX3; SOHLH2; TONSL; RING1; ZNF529; HNF4G; ZNF34; PDX1; GCM2; ZFP2; SRCAP; CBX8; GRIP1; ETV2; TULP3; ZNF460; PROX1; MNAT1; CEBPB; OSR2; ZNF350; SOX21; NR6A1; PPARA; ZNF157; NR5A1; RAX; NKX2-5; VHL; ZNF43; EYA3; MLLT1; MYF5; FOXE3; HOXD11; TAF1A; GCM1; SSX7; PAX3; PRDM2; KLF8; EMX2; ASCL2; RBFOX2; CDIP1; ZNF79; ZNF467; GSC2; TAF7L; TBX5; LBX1; ZNF268; POU2F3; MED31; KLF3; ALX3; CNOT2; CDX4; ACTL6B; ZNF202; GBX2; HBP1; POLR3C; NAB2; PAX7; ZNF606; SIX3; FOXD3; THRA; PRDM12; ZNF41; ZKSCAN5; AFF2; ARNT2; ETV3; FOXN1; SUV39H2; JAK2; FOXF2; POU3F3; ZNF135; ELK4; ZNF354A; ZNF444; SKIL; ZNF440; ZFHX2; ZBTB7C; RARG; SUPT3H; ZFP37; SOX5; HOXB8; PHIP; ZNF473; MSX2; HES2; SP1; TRIM33; ZNF334; ZNF667; TBX1; NEUROD1; DCC; ZNF771; NEUROD2; GFI1B; HNF4A; OVOL2; ZNF671; ASH1L; HOXC11; ZKSCAN3; NHLH1; ZNF140; NOCT; NANOG; SPI1; PIAS4; ZNF44; ZNF215; SUPT7L; ZSCAN2; ZIC4; ZNF571; ATN1; HDAC5; ZNF544; HOXC5; ZNF286A; NKX3-2; ZNF112; ZNF250; PRDM1; UTF1; BCL6; ZNF224; TFDP3; SSBP3; TLX1; NFYB; CCNT1; HMX1; PITX3; HSF1; TDRD3; HOXD12; MECP2; DLX5; DMRT1; HLF; CRX; TEAD4; FOSB; ZNF665; ZNF33B; AR; ZNF208; TAF6L; MAPK8IP1; TAF5L; NKRF; CITED2; ID1; PBX1; RUNX3; SOX1; POU2F1; BACH2; NR0B1; YEATS2; POU4F2; ARID3B; NRL; LYL1; TCF7L1; ISL1; JUP; KLF13; LIN28A; CAMTA1; PIAS1; JUNB; IKZF3; ZBTB16; EGR4; CBFA2T2; ZHX2; VAX2; SNAI1; SPIB; ZNF177; ZNF654; ARID5B; NCOA2; PAX6; ZNF492; ZNF35; HOXD1; LHX2; ZNF430; ZNF257; SUPT4H1; IRF8; INSR; ZNF136; ZNF528; DLX2; ZNF532; ZNF652; NR4A2; CIR1; PKNOX2; ZNF580; ZNF205; TAF5; USP21; HIRA; OVOL1; NR2E1; ZNF175; NR5A2; MNDA; TDP2; HLX; BNC1; ZNF32; ESRRG; CEBPG; ERBB4; INSM1; TERF2; ZNF623; RXRG; RYBP; ZNF551; STAT4; ZNF426; L3MBTL1; SSX3; NEUROG1; ZFPM2; ZKSCAN7; DLX4; ZFHX3; SALL1; ARID3A; SOX15; THAP10; ZNF12; ZIM2; CEBPE; HOXD3; PRDM5; SOX11; OLIG2; ZNF611; TFDP2; ZSCAN18; HEY1; NR2F1; PEG3; TOX; NFIC; WHSC1L1; ZNF83; GRHL2; GFI1; ZNF107; SAP18; NFIX; TRPS1; EYA1; TGIF1; TFAP2C; HHEX; ZNF84; EP300; NFE2; TP63; ZNF93; FOXG1; KAT6B; NCOA3; ZEB1; WT1; HOXB2; ZNF329; ZBTB20; ZNF432; SOX17; TAF9B; SP140; FOXA1; HOXB13; TAL1; ZNF536; PRRX1; TCF21; TBX21; MED21; POU2AF1; TLE2; TFEC; SHOX2; MAFB; SNAI2; CRYM; SOX2; TSC22D3; MDM2; IRF1; ZFP36L2; NR1H3; ZIC1; CBX7; PLAGL1; FOXF1; RSF1; ARID1A; TERF1; LHX6; TWIST1; TSC22D1; KAT2B; NR1H2; RORA; HMBOX1; ZNF589; DAXX; SMAD1; MYCN; SIX2; ZFP36L1; AEBP1; ZNF165; GTF3A; NKX2-2; IFI16; MYRF; FOXA2; PAX5; GATA6; TBX3; GATA2; SSX1; ID4; MEOX2; EGR2; HES1; ESR1; SSBP2; E2F2
Down-regulation 109 NFKBIA; BRCA1; ATF1; SUV39H1; XBP1; RHOA; NEDD8; ENO1; TBP; CCNA2; RBBP4; NR2F6; CRK; HOXA5; SND1; SMAD3; PBRM1; MAGED1; HNRNPD; SMARCC1; PUF60; WHSC1; AFF1; HDAC2; EDF1; NUP62; HOXC6; SFPQ; FLNA; MTDH; CTR9; HDAC6; SMAD2; FOXO3; CNOT1; HDAC1; USP22; USF2; NCOA4; ZBTB38; TCERG1; PRKDC; NCOR2; NRIP1; CENPF; BRD8; TRIM16; RB1; BLM; RBM14; KDM2A; BCLAF1; BIRC2; FOXJ3; CHD4; ZMIZ2; SNW1; ZBTB1; HLTF; SCAND1; TRIM32; CEBPZ; SMARCA5; HMG20B; UBP1; VEZF1; PIAS3; RUNX1; SREBF1; BHLHE40; MEF2A; CBX3; CRY1; ZBTB18; PURA; SMARCE1; NELFB; SMARCA2; BMI1; MED1; ZEB2; HMGB3; WWTR1; NR1D2; REPIN1; PHF20; BRD3; MBD2; NPAT; BBX; ELK3; HOXA10; DNMT3B; JARID2; STAT1; CREB3L2; DDX5; YWHAB; PDLIM1; TCF12; PTTG1; IKBKAP; RBBP8; NR2F2; FOXC1; PSIP1; SATB1; KDM5D; NR3C1