Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09791 Mitoxantrone GSE70138 HA1E Human 24h 3.33uM EID0003
Types Number Response transcription factors
Up-regulation 572 CEBPD; MEF2C; SPDEF; ARL2BP; NFATC4; SIX6; GBX1; HIF3A; ZNF75D; FOXJ1; AR; ZNF154; ZNF264; CARF; RORB; ZNF467; HSF4; PRDM14; SRCAP; ZXDC; MAML3; ZNF688; NR2E1; FEZF2; PAX1; ZKSCAN4; ZNF117; ZNF345; RFX1; SOX5; IRF6; ZNF141; CDX1; PBX1; HOXB1; ZNF273; MEIS2; CREBL2; ALX4; SOX21; MED12; OVOL2; THRB; ZNF701; HDAC5; ZNF814; PSMD9; ZNF816; SCRT1; ZNF586; ZNF835; L3MBTL1; CHD2; PDX1; ING4; VSX1; SCAI; TDP2; RING1; LZTR1; ZNF500; RFX3; RORC; SRY; ZNF550; HIPK2; ONECUT1; ASCL3; REL; ZNF274; ZNF544; CIITA; ATOH1; VGLL1; ZNF606; SOHLH2; MECP2; ZNF551; PROP1; PAX7; CCNH; ZNF573; SALL2; TAF1C; HOXB8; TP73; ZNF235; GLI3; ZNF136; SIX3; POU6F2; ZNF10; TAF9B; EMX2; ZNF695; FOXO4; KDM5C; TULP1; CD3D; HOXC5; MYCBP; ZNF287; ATF3; CREM; SOX3; NEUROG2; PRDM9; HAND2; VPS72; AEBP1; THRA; HOXD3; ZNF76; ZNF225; ZNF211; SOX18; ZKSCAN8; ZBTB3; ZNF224; ZNF415; E2F4; FOXD3; TBX4; CRTC1; TEF; LDB1; SIX5; HEYL; NFE2L2; BCL11A; ATF6; NKX2-5; NR6A1; ALX3; ZNF667; NHLH2; ZNF771; DLX5; GFI1B; DOT1L; ZNF778; SPI1; NKX3-2; NEUROD4; ZNF471; TBX5; POU3F3; ATN1; ZNF528; ZNF254; POU2F3; ZIC3; TONSL; ZNF221; TBX10; TLX2; NEUROD6; FOXH1; ZNF132; KDM5A; HDAC11; ATF7; TLX3; ZNF611; ZNF549; ZNF44; ZNF253; NEUROG3; EP300; HESX1; ZNF562; NEUROD2; ZNF124; ZNF80; GRHL2; ZNF180; ZNF440; ZNF74; WT1; EHMT2; TFAP2A; THAP9; ZNF749; POU4F3; HNF4G; ZNF682; NFIC; ZNF391; PAX3; LHX3; RBPJL; TBL1Y; RAX; FOXB1; MYCL; GSC2; MAPK8IP1; EMX1; NFIX; RFX2; ZNF665; LIN28A; ZXDB; MYF5; TAF6L; NR0B1; PRDM1; GRIP1; PEX2; ZNF671; ESRRB; ZFP2; BRWD1; ELK4; ZNF350; ZKSCAN3; PFDN5; NR5A1; FOS; ZNF711; ZBTB7B; POU1F1; ZNF484; MLLT1; ZNF669; ZNF407; TULP2; ZNF343; TBX19; FOXE3; ZNF362; ST18; ZSCAN2; ZNF215; LZTS1; ZFHX2; TAF4B; POU6F1; ZNF155; VENTX; ZBTB48; ZNF780B; SOX1; ZNF43; ETV2; ZNF623; SMAD5; STAT2; BCL6; WNT4; ASH1L; NFX1; ZNF334; NR4A1; TRIB3; BARX1; SUPT3H; HAND1; HNF4A; TXNIP; RFXAP; ZNF710; ZNF674; GCM2; AIRE; MECOM; MAK; ZNF654; ZNF214; LBX1; ZNF208; PITX3; ZNF223; ZNF304; CBX2; CBFA2T3; IKZF2; ZNF81; ZBTB7C; TAF7L; ETV1; MZF1; SAP18; GBX2; ZNF91; ZFPM2; SOX14; ASCL2; MYEF2; TAF1; NR4A3; KLF9; SOX17; HNF1A; ZNF205; ZNF492; TSHZ2; PPARA; PRRX1; SP4; ZNF394; PAX6; PRDM2; TWIST1; NR5A2; SSX7; FLI1; ZSCAN9; ZNF232; ZNF480; TBX1; ZBED2; AFF3; DLX6; KLF13; ZNF195; CRX; HES2; KDM4C; TLX1; ZNF442; POU3F2; GATA1; HOXD13; NRL; ZNF174; CUX2; ZNF135; ETV3; TCF21; NEUROD1; HOXC8; EPAS1; INSM1; ARNT2; NPAS1; HOXD12; NR1H4; TUB; LYL1; ZNF557; HMX1; PRDM12; PAX4; EHF; NHLH1; INSR; SETDB1; NR4A2; TAL1; ACTL6B; TCEA2; KLF7; ZNF41; ERBB4; ZNF358; VHL; RBL2; ZNF268; PBXIP1; CREG1; ZBTB44; OVOL1; SKIL; ZNF157; HIC2; SHOX; CDIP1; FOXF1; DCC; TBX21; SSBP3; ZSCAN18; JUP; TBX6; CHD3; IKZF3; GCM1; ZNF134; ESR2; NR0B2; TFDP3; SNAI1; RARG; NACA2; BACH2; ZNF331; ZSCAN31; RBFOX2; POLR3C; ONECUT2; BRDT; PRMT2; ZNF532; ZNF257; HSF1; ZNF787; CALR; ID4; ARID3A; ZNF493; TRIM24; NR2F1; TULP3; ZNF652; MAP3K10; FOXF2; TCF4; CERS6; HOXD1; CNOT3; RCOR3; NANOG; ZBTB17; TCEA1; MYNN; ZNF33B; UTF1; ZNF675; POU3F4; SKI; ZNF813; KAT2B; HHEX; PRDM10; CEBPE; AES; GTF2I; NEUROG1; YBX2; HINFP; HOXA2; ZNF423; RNF14; IRF1; SMARCB1; ZNF177; NFAT5; PROX1; PKNOX2; CBX4; SSX3; KLF15; MED15; PRDM5; PAXBP1; ZFY; TCF7L2; NKX6-1; ZNF426; ARRB1; ZNF219; SOX13; CNOT2; BCL11B; PBX2; ISL1; AFF2; ZNF93; HOXD11; TFDP2; ZNF32; FHL5; CBFA2T2; TBR1; NKX2-2; WHSC1L1; DBP; HMBOX1; THAP10; ZNF83; HLX; LHX6; TAF12; PHF1; AFF4; TOX; HIRA; ESRRG; ZNF3; ARNT; HBP1; ZNF184; ZNF354A; TEAD3; SLC2A4RG; STAT4; CDX2; SOX2; CBX7; OSR2; MYCN; KLF3; EYA1; ZNF22; TGIF2; MXI1; ZIM2; FOXN3; CTNNB1; ARID3B; TRPS1; SSBP2; FOXA2; GFI1; ZNF165; ZNF589; MNDA; ARNTL2; MEIS1; SHOX2; OLIG2; POU5F1B; MYT1; LHX2; SMAD6; ZBTB16; RSF1; FUBP1; RORA; FOSB; EN1; ZNF107; NR1H2; TRIM22; MEOX2; FOXA1; ZHX2; ZKSCAN1; BNC1; HMGA1; PLAGL1; ZNF536; TERF1; ZNF175; ID3; IFI16; ZBTB20; HEY1; ARID5B; SP140L; SNAI2; JAK2; RXRG; YBX3; HDAC9; E2F5; TCEB2; DACH1; NR1H3; DLX2; MYRF; SOX11; ID1; BHLHE41; TCF7; KLF5; HOXB13; PEG3; BNC2; ZEB1; TGIF1; IKZF1; IRF8; LEF1; EYA2; ESR1; TFAP2C; HES1; E2F2; SATB1; GATA2
Down-regulation 192 FHL2; CCNA2; PUF60; XBP1; CRK; NFKBIA; BASP1; NUP62; MYC; SUV39H1; FOXO3; FOSL1; HOXA5; NFIL3; USP22; EZH2; RBM14; SCAND1; HNRNPD; SNW1; TBP; BRCA1; ATF1; MED6; SOX4; MED1; HOXA10; BHLHE40; FOXJ3; CDK7; EED; HOXC6; ZBTB11; CTR9; AATF; ING2; PAX8; CNOT1; TRIM32; ADNP; FOXD1; SFPQ; RBBP7; CCDC59; BCOR; TSC22D2; BCLAF1; CENPF; DRAP1; SMAD3; TLE1; UBE2I; SERTAD2; DNAJC2; CREB3L1; SETD2; EDF1; TRIM16; KAT7; BRD3; NCOR2; VEZF1; BRD8; NELFB; PLAGL2; NRIP1; ID2; NKX3-1; TRIM28; POLR2A; BRPF1; REST; SOX9; NCOA6; TBPL1; PCGF2; ZNF146; CTCF; PRPF6; ECD; MYBL2; TAF5; TCERG1; ZMIZ2; SIAH2; CRY1; BMI1; ELF5; SMARCC1; ZZZ3; DDX54; ITGB3BP; TP53; SMARCA5; NFYC; SF1; CARM1; HOXB7; CCNC; NPAT; AFF1; CEBPZ; CTBP2; CHD1; NRBF2; KDM2A; MBD2; SMAD7; HOXA11; TGFB1I1; ANKRD1; HMGB2; IKBKAP; FLNA; NR2F2; ZMYM2; MED13; RBL1; ATF4; PPRC1; SMAD2; UBP1; MAGED1; MNT; TBL1X; MGA; KLF6; MAZ; CIZ1; MTF2; PHF20; RBPJ; ZNF263; BLM; MED24; YWHAB; KMT2A; BATF3; FOXC1; RCOR1; JUND; RUNX3; DEK; ERG; ZNF410; ZBTB1; RELA; CBFB; WHSC1; POU2AF1; ZBTB18; MED4; CNOT6; CBX3; KLF10; RAN; CENPB; PTTG1; BIRC2; APEX1; HSF2; RUNX1; ARNTL; MEF2A; FOSL2; PATZ1; BAZ1A; SAP30; RLF; DDX5; PRKDC; HOXC10; HTATIP2; PURA; TAF10; ZNF267; ZBTB38; SIX1; IRF7; KDM5D; ELK3; SMAD1; EGR3; ERBB2; WWC1; HOXB6; CREB1; IRF4; EGR2; NFATC3; NR3C1; ABL1