Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09587 Mitoxantrone GSE70138 HA1E Human 24h 3.33uM EID0002
Types Number Response transcription factors
Up-regulation 671 FOXJ1; ZNF562; NR2F1; NFE2L2; DLX2; RAX; HBP1; E2F4; ZNF816; CRTC1; TAF6L; PROP1; RCOR3; MZF1; TRPS1; GATA1; YAP1; PBXIP1; RSF1; ZNF771; PITX3; HSF4; HDAC11; LDB1; HIF3A; TAF1; SRCAP; TCFL5; ZNF556; ETV1; MAP3K10; HMBOX1; MXI1; DDIT3; LHX3; GBX1; MED25; HOXC5; LHX6; HEYL; PBX2; SOX5; SOX2; PEG3; CEBPE; HMX1; ZKSCAN3; RBPJL; TFAP4; ZXDC; NHLH1; STAT4; RFX1; ARL2BP; EPAS1; NFE2; ZEB1; ZFHX2; CEBPD; KLF9; NFIX; HINFP; ID4; PDX1; RORC; TBX4; TGIF1; PPARD; CD3D; NEUROD6; TCEA2; NFIC; PITX1; ELK4; MLXIPL; ZNF500; CAMTA2; NKX2-5; TONSL; ZSCAN18; TBX10; LZTR1; HHEX; HOXB1; ETV6; E4F1; NKX6-1; ERBB4; AR; LHX2; DBP; MED31; IRF9; CDX4; ZBTB16; ZNF154; HIPK2; HABP4; NEUROG3; KDM5C; PLAG1; MED12; KDM5B; DYRK1B; GCFC2; IKZF4; FOXF2; SUPT3H; NR1H3; ZBED2; ZNF331; ZSCAN32; EP300; ZNF75D; HAND2; TUB; NR0B2; NOCT; ZNF211; ZNF688; THRAP3; KLF7; OVOL2; ZNF557; ZNF232; ZBTB48; NEUROG1; MAML3; TBL1Y; GLI1; ZNF205; ZNF276; MAFK; NR4A2; FEZF2; NR1H2; ZNF701; HIRA; ZNF117; CCNT1; THAP3; BARX1; CCNH; NR5A1; RARG; TRIB3; CRX; ZNF221; NEUROD2; IRF1; SUPT7L; TRIM33; PMS1; SKI; FOXP3; FOXN1; SRY; TAF1C; SOX18; FOXA2; ZNF415; ASH1L; ZNF770; ZNF623; NAB2; ZNF671; RING1; EZH1; NFATC4; ALX4; TSHZ2; SMARCD3; MYRF; TBX1; ESR2; ZNF304; PRDM14; TLX1; EHMT2; ZKSCAN4; GRIP1; SUPT4H1; REL; CBFA2T2; TBX5; SOX21; TCF3; GLI2; ZNF268; ZFX; ZNF335; AFF4; KLF15; THRB; TEAD3; NR2F6; SOX13; TBX21; PAXBP1; PAX1; SOX1; NCOA3; ETV7; FOXL1; FOXH1; PHF1; CREM; ZNF91; PRDM2; FOXL2; POU3F3; ZSCAN9; ZNF180; NPAS1; PAX7; CALCOCO1; ATF6; ESRRB; ZNF174; ZNF74; CHD2; ARID3B; VSX1; SCRT1; DCC; NRL; RNF14; HEY1; HOXC11; ZNF528; PIAS4; PRDM1; CEBPB; ETV2; NR2E1; ZKSCAN8; ZNF177; ZKSCAN5; NFAT5; AIRE; ZBTB7B; ZNF667; NR4A3; SOX14; RORB; ONECUT2; CBFA2T3; TP73; POU6F1; NCOA2; KDM4C; THRA; ZNF10; TEF; ZNF112; L3MBTL1; DOT1L; PRDM12; ZNF223; SSX3; SCAI; ASCL3; ZNF695; ZNF107; WHSC1L1; FOXC2; TBX3; MECP2; MEIS2; TULP1; HOXA6; SIX6; PBX1; ZNF175; CEBPA; CBX4; NR6A1; ZNF225; ZNF813; SPDEF; TFCP2; PROX1; ONECUT1; RB1; TRIM22; SOX3; ALX3; ZNF76; TULP2; GSC2; TLE2; THAP7; ZNF549; ZNF93; NFYA; SPIB; SP140L; SIX3; ZNF124; ZNF480; FOXB1; ZNF573; EMX1; HOXB8; NFX1; PRDM10; ZNF264; DLX5; TRIM25; POU6F2; ATOH1; SSX7; CARF; NR5A2; WNT4; ZNF749; RFX3; IKZF1; TLX3; ZNF467; TSC22D3; PRDM9; EVX1; APBB1; BCL6; PEX2; BACH2; MKL2; POU4F3; ZNF142; ZNF350; ING4; CUX2; UBE2L3; ZIM2; ZNF200; KAT6B; PRDM16; MLLT1; CBX2; PAX6; ZBTB20; SMAD6; HOXD12; HESX1; SOHLH2; ZNF778; ZNF273; VENTX; SMAD9; IFNB1; HIC1; TBX6; HES2; ZNF8; SOX17; ZNF324B; VAX2; SHOX; NKX2-2; CERS4; ZNF79; PAX3; TFAP2A; TDP2; MAK; SAFB; DMTF1; ZNF654; FOXF1; LYL1; OVOL1; NEUROD4; ZNF253; BPTF; TAF1A; CDK8; NEUROG2; ZNF41; MED17; ZBTB7C; NR1H4; SIRT7; ATF5; RXRA; MAPK8IP1; CREBL2; ZNF195; SNAPC4; VPS72; ATF7; HNF4G; DLX6; KLF1; JUP; PRRX2; HOXD3; TSG101; WDR77; OLIG2; ZNF202; HOXA3; SPI1; PAX4; HOXC4; HOXC8; ZNF343; ZNF835; SP1; ACTL6B; IKZF2; BRWD1; CDIP1; THAP9; ZXDB; ZNF814; ST18; TAF9B; AFF3; RNF2; CBL; FOXD3; CDX2; GFI1B; ZNF550; PPARA; SSBP3; PGR; HIC2; YY1; ZNF287; ARID3A; BCL11A; SKIL; ZBTB44; TAF9; ZNF692; TGIF2; AFF2; STAT2; FOS; MYF5; SMARCA1; ZNF471; ZNF665; GBX2; ING3; NKX3-2; ZNF239; ZNF157; ZNF407; ZNF219; ZNF682; ETV3; ZNF391; ZBTB3; KLF3; IRF6; SNAI2; PRDM5; CHD3; FOXE3; NR0B1; ZFPM2; TBR1; ATF3; ZNF80; HLF; MYOG; ZNF214; FOXI1; VHL; HOXD13; ZNF711; CREB3L2; POU3F1; SHOX2; LEF1; ZNF132; ZNF444; VGLL1; TERF2; ZNF266; HOXA2; GCM2; ZNF426; ZNF442; TFDP2; STAT3; ZNF544; PAX9; ZNF81; CBX8; BRDT; ZNF224; POU2F3; TCEA1; TFDP3; ZNF419; FOXA1; NR1I2; PKNOX2; ZNF606; ZNF3; TAF5L; ZNF235; GCM1; ZNF345; ZNF250; ZNF234; EYA3; ZNF674; ZNF696; HOXA4; SUV39H2; ZNF532; HDAC5; MAFB; ARNTL; TAF7L; ZNF257; ZNF362; MYEF2; ZNF85; POU1F1; BATF; MED14; POLR3C; SALL2; ZNF669; HDAC4; PRDM13; ZNF710; ZNF274; ZNF613; ZNF135; TP63; KLF8; ZNF134; ZIC3; ZNF215; ZFP2; ZNF780B; POU3F4; ARNT2; TXNIP; ZNF140; LIN28A; PRRX1; JUN; PFDN5; ZHX2; HDAC9; TAF4B; NR1I3; ZNF675; ZMYND11; GLI3; ID1; FOXE1; ZNF510; ZNF611; BNC1; ADRB2; IKZF3; RNF141; MSX2; SOX10; EYA2; ZNF165; PPARGC1A; ZKSCAN1; ARID5A; ZNF506; TCF21; BANP; SOX15; AEBP1; ZNF337; ZIC4; JUNB; NANOG; ZNF440; ZFP36L2; EGR4; UTF1; ZSCAN16; IRF3; IRF8; ZNF507; CDC5L; TBX19; PIAS1; ARID4B; ZNF208; BHLHE41; CIR1; E2F5; KAT2B; ZNF589; KLF13; ZNF141; TCF7; RARB; ZNF334; MLLT10; PAX5; FOXG1; TAL1; GFI1; SP4; HAND1; VDR; ZNF34; FOSB; MXD1; FUBP1; POU5F1B; ZFP69B; RORA; HOXA1; SATB2; NEUROD1; ZNF492; ESRRG; RBL2; SSBP2; TSC22D4; PNRC1; ZMYND8; CBX7; ZNF44; ZNF571; ZNF254; ZNF324; NFKB2; ZNF430; HEY2; IFI16; PBX3; MDM4; SSX1; BCL11B; ZNF83; JAK2; FLI1; CREB1; ZNF43; GATA6; MEF2C; LITAF; TCF7L2; ZIC1; KLF11; SATB1; SOX11; EN1; MDM2; OSR2; TCF4; IKBKAP; ID3; GATA2; MYBL1; ZNF586; WT1; E2F2; MYB; ESR1; DACH1; TOX3
Down-regulation 197 CRK; FHL2; NUP62; USP22; SNW1; XBP1; DRAP1; BASP1; PAX8; FOSL1; NRIP1; TBP; TP53; CENPF; HOXB7; APEX1; RBPMS; HOXA10; TCERG1; SMARCE1; SFPQ; NPM1; DNAJC2; MED6; SUV39H1; PATZ1; NFE2L1; WWC1; KAT7; ERBB2; HMG20B; UBE2I; ZMIZ2; LOXL2; HOXA5; PTRF; BCLAF1; FOXJ3; PUF60; TLE1; HNRNPD; EDF1; EZH2; SCAND1; TRIM28; TSC22D2; FLNA; PCGF2; ENO1; ECD; NCOR2; YWHAB; MED24; ZNF146; HOXC10; NFYC; YBX1; UBP1; RFX5; YBX3; AATF; BAZ1A; RAN; CCNA2; TRIM32; PA2G4; MAZ; NFKBIA; KDM2A; WHSC1; CREB3L1; TGFB1I1; DAXX; SMARCA4; TEAD4; USF2; HOXB6; NR2F2; MED1; CBX3; TRIP6; PQBP1; RBM14; SMARCC1; PMF1; HOXC6; PCBD1; DDX54; SETD3; NKX3-1; RLF; NELFB; FOXO3; PTTG1; SMARCD2; SUB1; ZBTB38; TCF12; RCOR1; TBL1XR1; EMX2; NACA; FOXM1; FOXD1; BMI1; MTDH; ZNF302; HSF2; NONO; BATF3; NCOA6; AFF1; PKNOX1; SSRP1; BIRC2; CRY1; CTR9; ITGB3BP; ZNF12; SIX2; CARM1; NEDD8; NFIL3; FOXC1; CCNC; PIAS2; TBPL1; ZBTB24; HCFC1; BRPF1; COPS2; ETS2; SETD2; RUVBL2; DNAJC1; CTBP2; RBBP4; DDX17; DNMT3B; HDGF; MYC; DEK; SP3; RBPJ; SAP30; CTCF; RELA; HMGB1; SMARCA5; MYBL2; MAX; CBX5; FOSL2; KLF6; RNF4; BTF3; ELK3; FOXN3; CTBP1; TAF10; DR1; SMAD2; ZNF292; MEF2A; HDAC1; ERG; RYBP; ZNF410; CARHSP1; ID2; PRKDC; TCEB2; SIX1; RUNX1; MAGED1; JARID2; CCDC59; MBD2; SUZ12; HTATIP2; LMCD1; ATF4; NCOA4; HLTF; TSC22D1; TLE4; RUNX3; ZEB2; MNDA; PSIP1; HMGN3; MSX1; PDLIM1; ABL1; CEBPZ; WWTR1; TFAP2C