Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09566 Linsitinib GSE70138 HA1E Human 24h 0.12uM EID0002
Types Number Response transcription factors
Up-regulation 474 SOX11; E4F1; PBXIP1; IRX4; NFE2; ZNF629; MYRF; HINFP; CBFA2T3; GATA1; ZNF467; TERF2; CAPN15; BCL11A; JUP; TCEA2; VAX2; MAML1; SSBP3; MAP3K10; ZNF91; NR1H2; GTF2IRD1; MKL2; LYL1; THRA; HLX; ZNF276; SHOX; SALL2; SCMH1; GFI1; ZHX2; HDAC11; CRTC1; REPIN1; IFNB1; CDIP1; NRL; TBX19; TAF1; ID4; CBX2; NFATC4; VPS72; CREM; ST18; YAP1; ZNF175; ALX3; PRRX2; RARG; ZNF500; BARX1; HSF4; FOXJ1; TGIF2; CALCOCO1; DNMT1; TFDP3; PAX3; FOXA2; SSX3; KLF15; PPARD; TFAP4; HHEX; MBD1; NKX6-1; EPAS1; ZFHX2; SSX7; ZNF286A; ZNF124; BNC1; CEBPD; ETV6; TBX5; HOXC5; HEY1; SOX5; HIRA; TXNIP; PROP1; KAT8; PDX1; PRDM14; ZNF331; SOHLH2; TP73; TRIM16; TAF1C; HOXD13; ZBTB40; PLAGL1; GRIP1; ZIC1; TBX10; MEIS2; TLX3; SRY; TGFB1I1; ZNF219; FOXF2; ASH1L; FOXE1; HOXA1; SRCAP; NPAS1; NR4A3; ERBB4; NKX3-2; TCFL5; ZNF710; ATN1; ARHGAP35; AIRE; NEUROD2; IL16; TCF25; HIF3A; TRIP11; FOXF1; CREB3L2; TFAP2B; WNT4; LHX3; MTA2; ZNF189; ZNF688; ING4; ETV1; CERS4; ZKSCAN7; ZFHX4; PRRX1; ARID3B; HMGXB3; ZNF117; SOX14; ZNF492; ZNF257; ZNF263; THRB; ZNF771; IRF7; NEUROG2; RBFOX2; NR4A2; MYF6; MEOX1; EYA1; ZNF154; TBX4; RARA; TEF; SMAD1; RNF141; HIPK2; ZNF85; ZKSCAN8; E2F5; POU6F2; ZKSCAN5; HESX1; LITAF; TFAP2A; IKZF4; SPDEF; HEY2; ZNF770; NEUROG1; TBR1; PBX1; GFI1B; SOX15; HAND1; SOX1; NFX1; TULP2; PROX1; LHX6; AFF3; TCF4; KLF8; NR2E1; ZNF345; TBX1; ETV2; ZIC3; MNX1; PEX14; NOCT; KLF9; POU1F1; ARID3A; ZBED2; BCL10; ATF7; IRF4; LHX2; NEUROD6; ZNF221; LHX1; ZNF512B; TRPS1; PLAG1; POU3F4; SHOX2; GBX2; ESRRG; PRDM2; PRDM1; SMAD9; SMARCD3; TAL1; ZKSCAN3; ZNF778; HOXC11; TULP1; ALX4; TBL1Y; ETV3; ZNF423; POU4F3; RORB; RARB; ZNF132; ZBTB3; NR5A1; MXI1; RNF2; HOXD12; TTF2; ONECUT2; FOXN1; ZBTB7C; PRDM10; TCF3; ZNF529; ZNF816; CHD2; SOX21; HOXC8; PRDM5; ZNF652; MED20; ZNF214; ZNF415; CCNT1; ZNF695; EYA3; MAML3; HOXB8; SIX2; EMX1; SCAI; POU2F3; CBX8; SCRT1; ZNF557; ZNF334; ZNF669; ZNF623; MYEF2; CDX2; ZKSCAN4; ZNF343; ZNF324B; SIX3; ASCL3; POU2AF1; HES2; ZNF74; ZNF665; ZIM2; HDAC5; NHLH1; PAX5; FEZF2; SP4; OLIG2; ZNF224; ZNF93; BCL6; SSX1; SUPT3H; ZNF692; POU6F1; PAX4; CBX4; MAK; FOXI1; ZNF589; IRF3; JUN; STAT4; PAX6; FOXE3; NFATC1; PRDM9; ARNTL; KLF1; ZNF254; GCM1; ZNF549; TRIM29; TP63; NR0B1; VHL; GLI3; NR3C2; ZNF407; GSC2; ARL2BP; KDM4C; PGR; TRAK1; ZNF141; ZNF780B; ZNF701; PRMT2; ZBTB16; JAK2; TRIB3; NCOA3; KAT6B; SOX13; SKI; ZNF41; SOX2; ZNF43; ZFP2; ZNF749; ZNF507; PKNOX2; ZNF234; ZNF235; EN1; ZNF573; SOX18; KLF3; ZNF81; ZNF215; TAF7L; TLE2; TCF7L1; BRDT; NR2F6; ZNF157; RFX3; ZNF442; ZFP37; ZNF506; ZBTB48; ZNF223; DCC; ZNF136; ZNF814; ZNF606; ZBTB44; ZNF460; ZNF253; ZNF208; CERS6; ZNF287; THAP9; VDR; FHL5; GLI2; ZNF391; BRCA2; MAF; ELK3; L3MBTL1; GCM2; TWIST1; NANOG; ZNF362; SPIB; ZNF471; ZNF177; FLI1; CIITA; TCF7; HOXA2; VENTX; ZNF80; ZNF674; TCF7L2; INSR; FOXH1; SMAD5; CIR1; NKX2-2; STAT2; ZNF493; EZH1; PNRC1; MDM2; MDM4; ZNF225; VGLL1; DLX5; KLF4; ZNF324; ZNF667; MYB; AHR; AR; ARNTL2; MAFF; MBD4; CD3D; SOX3; TBL1X; ZNF682; ZNF675; ZNF571; SOX17; MYCL; ZNF273; NR5A2; POU5F1B; FOXG1; NFAT5; ZNF202; IRF6; BTG1; ZNF10; BACH2; CBX7; ZEB1; EGR2; KLF11; ZNF264; PEG3; ZNF430; ZFP69B; MEF2C; IRF9; NR1H4; TCF12; MAFB; MNDA; JUND; LIN28A; SALL1; ZNF232; FUBP1; ZNF611; AEBP1; ZNF711; ZFP36L1; ZSCAN18; JUNB; SATB1; TFEC; CEBPA; IRF8; ZNF721; SSBP2; INSM1; CUX2; HIC2; ZBTB18; THAP11; TOX; TOX3; WT1; NEUROD1; NFKB2; TLE4; HES1
Down-regulation 135 ENO1; YWHAB; FLNA; USP22; HOXB7; NFATC3; FOXM1; SFPQ; EDF1; SMARCC1; XRCC6; RNF10; ZNF268; SNW1; ZNF281; FHL2; RCOR1; TSC22D2; ZNF217; DAXX; KLF6; BAZ1A; ZBTB11; TP53; SUZ12; SP2; RFX5; HIF1A; BASP1; RUVBL2; RNF4; FOXJ3; ATF4; BRCA1; TBPL1; NACA; SMARCA4; HOXC6; ZNF443; PRKDC; RAN; NPM1; TBP; HLTF; SIM2; KDM2A; BRD2; NONO; E2F3; SMAD3; CBX3; HNRNPD; USF2; BCLAF1; PURA; COPS2; CBFB; NFE2L1; MAFG; CARM1; TOB1; NFIB; ZNF84; HDAC1; PSMC3; KAT7; ARID4B; WWTR1; AATF; TAF1D; TFDP1; TBL1XR1; TRIM28; PQBP1; UBP1; MAZ; ATF7IP; YBX3; PLAGL2; NEDD8; RBM39; EZH2; SP140L; CARHSP1; JARID2; HMGB1; BCOR; BTF3; RBBP7; NKX3-1; BRPF1; RNF14; MTDH; TSC22D1; SMARCC2; HTATIP2; LPIN2; VEZF1; ETS2; TAF10; MED1; ILF2; CTBP1; NFYC; SPEN; RNF138; BRD8; ZNF419; SMAD2; SOX4; PAWR; FOXD1; RORA; ESR1; CREBZF; MAGED1; ZNF468; PTTG1; NR2F2; ZNF586; MEIS1; DEK; ZNF302; PIR; RUNX1; ZNF551; MECOM; BAZ2B; LMCD1; AFF1; KDM5D; CREB1; IKZF1; NR1D2; LEF1