Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09565 Linsitinib GSE70138 HA1E Human 24h 0.37uM EID0002
Types Number Response transcription factors
Up-regulation 460 ETV1; SUPT3H; SMARCD3; MAML1; LHX2; TAF1; CERS4; NEUROD2; TAF6L; STAT5B; HIRA; SOX13; VAX2; LZTR1; SALL2; TLE2; PPARD; FOXF2; TRIM27; NR1H2; CUX2; JUP; ZNF654; HMBOX1; ZNF771; DNMT1; SOX5; ZKSCAN5; NHLH1; TCFL5; PROP1; RFXAP; TBX1; SOX2; RRN3; NR0B1; MYRF; SOX18; NR2F1; BACH2; ZNF556; CDK8; PRDM2; ZNF467; ATN1; AFF2; TBX10; BCL6; PDX1; GBX2; NRL; IKZF1; SSX3; PROX1; SATB2; HINFP; NEUROD6; ARID5A; MTA2; INSR; OLIG2; THRA; ZNF263; ERBB4; TFAP4; ZBTB16; ARHGAP35; KLF15; PLAG1; THRB; PAX9; MAP3K10; HMGXB3; ARL2BP; NFIX; ZNF557; TBR1; ZNF74; RING1; ZKSCAN3; CBX2; HIPK2; ZNF512B; WNT4; NCOA3; TCF7L2; ZNF200; RORB; TP73; PAX3; CCNH; LHX3; ZIC1; ZBTB44; ALX4; SOX3; ZNF500; SCMH1; TAF5L; PKNOX2; MKL2; PGR; NKX6-1; ZBTB48; GLI2; TULP1; ALX3; TGIF2; HOXD13; YY1; TBX5; ZKSCAN8; TBL1Y; DCC; TLX3; AFF3; SUPT7L; PAX7; BRCA2; GTF2F1; CBFA2T3; ZNF695; TCEA2; BNC1; ATF7; NKX2-2; EMX1; ZNF770; ING4; JAK2; ASH1L; HHEX; SOX1; AR; TFDP3; IKZF4; SPDEF; TUB; IFNB1; FEZF2; L3MBTL1; ZHX2; NEUROG1; FOXF1; POU6F2; ATOH1; AEBP1; GATA1; GRIP1; BNC2; SCRT1; UBE3A; PRDM9; E2F8; SSX7; STAT5A; ZNF589; RBFOX2; WHSC1L1; ZNF507; AIRE; RNF2; POU6F1; HOXD9; SRY; HDAC5; TEF; SOX11; ZKSCAN4; ST18; ZEB1; ETV2; ZBTB7C; HSF4; CDX4; HOXD12; LHX1; TTF2; YAP1; CBL; PRDM14; NKX3-2; ZNF562; FOXN1; CEBPD; GCM1; ZNF221; PRDM16; NPAS1; EZH1; TEAD3; SP4; ZNF669; ETV3; ZNF142; ZFX; ZIM2; CALCOCO1; NR1H4; RUNX2; SOX14; SOX21; NOCT; ZNF710; PSPC1; CHD2; ZNF257; TAF1C; HOXC11; NEUROG2; HES2; HOXA1; ZNF529; RARA; ASCL3; ZBED1; PBXIP1; GLI1; TBX4; LBX1; UTF1; POU1F1; MYEF2; TDRD3; ZNF688; FOXE1; ZBTB3; ID4; CCNT1; CBX4; UBE2L3; ZNF337; VENTX; HESX1; ZNF343; TULP2; SOHLH2; IL16; MDM4; HIC2; FOXE3; ZNF391; PAX4; ZNF85; CREBL2; ZIC4; TRIB3; RARG; MED17; SHOX; ARID3A; PRPF6; NR2F6; NR2C2; ATF5; CLOCK; NFATC4; ZNF250; ZNF324B; ATF3; BARX1; PAX1; TBX19; ZNF324; TULP3; ZNF780B; ZNF132; ZNF362; ZNF623; GCM2; HOXB13; MEIS2; ZNF814; PRDM10; ZNF117; ZNF287; GSC2; ZNF442; ZNF177; ZNF711; MAML3; ZNF273; SNAPC4; ZNF692; IRX4; ZNF749; FOXA1; ZNF334; MYB; TFDP2; RSF1; ZNF532; HAND1; AIP; ZNF234; ZNF778; POU3F1; ZFP69B; HOXB8; NFX1; ZNF286A; ZNF32; FOXD3; ZNF232; ZNF682; ZNF492; SUV39H2; ZNF510; CD3D; ZNF345; NR6A1; ZNF484; ZNF33B; TAF9B; AGO2; ESRRG; TP63; FOXA2; BCL10; ZFP2; ZNF81; MED7; IKZF2; ZNF154; RAD21; PRMT2; ZNF549; ZNF131; FUBP1; SIX3; SCAI; MLLT10; IRF9; NANOG; ZNF667; ZNF214; POU2F3; MECP2; MSX2; CDX2; ZNF208; ZBED2; HDAC9; VHL; NR2E1; RFX3; KLF2; ZNF239; SKI; KLF7; THAP9; CARF; NEUROD1; ZNF235; ZNF215; LYL1; ZIC3; ZFP37; TCF4; MEF2C; ZNF407; FOXI1; ZNF93; SIX6; ZNF157; KAT6B; ZNF674; KLF8; IRF6; PRDM5; MED14; ZNF225; MED20; DMTF1; NFIC; EN2; NR1I3; NLK; ZNF471; HEY1; ZNF135; ZNF80; EGR2; CSDC2; CEBPA; IRF4; RFX7; ZNF124; E2F5; TCF21; CITED1; ZNF675; MAFF; VGLL1; ZNF665; ZNF236; HOXD1; JUN; NR4A3; OVOL1; CERS6; FLI1; ZNF426; ZNF91; POLR3C; PAX6; BRD4; ZNF202; TFAP2C; WT1; MYT1L; ZNF22; IRF7; ZNF253; PRDM1; ZNF175; GATA6; RBL2; BCL11A; PEG3; ZKSCAN7; TRIM16; NCOA2; POU5F1B; ZNF254; MYF6; ARID5B; HLX; KLF4; ZNF141; EPAS1; KLF9; BTG1; MDM2; KLF3; EN1; ZNF423; KDM5D; ZNF165; ZNF44; SPIB; ZFP36L1; TOX3; TAL1; SOX17; CREM; ZNF573; THAP11; PBX1; ZNF611; LIN28A; DACH1; TRPS1; LEF1; FOXG1; TOX; ZNF160; FOSB; NR4A2; ZFPM2
Down-regulation 138 DNAJC2; SNW1; SFPQ; ZBTB38; HNRNPD; TRIM28; NFATC3; SND1; MEOX2; XBP1; MYCBP; TSC22D2; ENO1; AFF1; NFYC; TP53; PSMC3; PCBD1; HIVEP2; BASP1; NEDD8; SIX2; USP22; DRAP1; ATF4; MSX1; NR1D2; EMX2; NUP62; SUV39H1; FOXD1; EDF1; CHD1; CARM1; ARNT2; AATF; CTCF; HOXB6; MED1; RUVBL2; HTATIP2; FOXO3; SMAD3; HDGF; HOXC6; SF1; TBL1XR1; SMARCC2; ZNF212; VEZF1; CREG1; SMAD2; SMARCA4; SP100; ORC2; CENPF; FLNA; PSMD9; RBM14; HCFC1; USF2; SMARCA5; ELF5; DDX54; SSRP1; EZH2; NRBF2; BAZ1B; NFE2L1; HSBP1; HMGA1; BBX; HOXB7; RNF10; RLF; HMG20B; KLF5; NACA; KLF12; TAF10; CBX3; PURA; MTA1; BAZ1A; MED24; TERF1; BMI1; RHOA; MAF; HLTF; JARID2; ZNF468; TOB1; BRPF1; SUZ12; SIX1; ZNF146; CREB3L1; YWHAB; CTBP1; FOXJ3; SUB1; FOXC1; CBFB; BIRC2; COPS2; ACTL6A; LPIN2; BRD8; RAN; MTDH; HMGB1; TGIF1; HDAC1; XRCC6; CTR9; DPF2; BCL3; MEIS1; NONO; ZNF586; BHLHE40; KLF6; ESR1; IKBKAP; PIR; BCL11B; PTTG1; ETS2; TADA3; ID1; PDLIM1; TSC22D1; PUF60; TRIP6; NKX3-1; ID3; NR3C1