Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09564 Linsitinib GSE70138 HA1E Human 24h 1.11uM EID0002
Types Number Response transcription factors
Up-regulation 195 TWIST1; CERS4; RRN3; ZIC1; BATF; IKZF1; KLF9; SMARCB1; ARID5A; AHR; INSR; TAF1; VDR; KLF7; LZTR1; FOXJ1; HMBOX1; PRRX1; TCF7L1; ALX3; ZFPM2; POU5F1B; HMGB3; NR0B2; SERTAD2; HIPK2; SALL2; HOXA4; TSHZ2; RBPJ; MYOG; MAK; BNC2; ZNF354A; MTF1; SSX1; STAT5A; MAP3K10; ZNF423; PRDM12; NR2F1; TAF5L; PRDM2; RORC; TCF4; ZBTB16; ZNF292; LMCD1; CEBPZ; VAX2; ARL2BP; HMX1; SMARCE1; RAD21; TERF2; ARRB1; REL; SSX3; WHSC1; SOHLH2; PLAG1; RNF2; HDAC5; FOXI1; HIC2; PEG3; ZSCAN9; KLF11; ZNF692; ERBB4; ASCL1; ATN1; ARNTL; PLAGL1; JUP; TTF1; EYA1; ZNF500; HINFP; TRIB3; MEF2C; RBBP4; ELF5; JUND; ZNF232; HEY1; PAXBP1; ZMIZ1; HOXC4; LHX3; CREB3L1; HHEX; THRA; RYBP; SOX11; ASH1L; FOXN3; PAX6; ZNF589; NFATC4; HMG20A; CREM; CTBP1; RARA; PCGF3; ZNF267; ZNF34; HLX; SUPT3H; AEBP1; IRF7; SOX10; NR4A3; MEIS2; NANOG; TBX19; SOX2; CREB3L2; BARX1; CERS6; PRDM10; PBX3; BANP; ZNF710; RNF138; CREBL2; PKNOX2; NR3C2; ZNF93; SPEN; CSDC2; PRDM14; ZFHX4; EN1; ZNF22; THRB; ZBED1; PPARD; ZNF224; SMARCD3; HIVEP1; PRPF6; BACH2; SPDEF; ZNF324; BTG1; CEBPD; TRPS1; TCF7L2; HMGB2; LIN28A; SOX5; ZFP36L1; ZHX2; GLI2; SIX3; PCGF2; HIRA; TCEA1; FLI1; CALR; ZNF665; TFDP2; MYCL; ZEB2; ZNF467; SMAD1; ZNF669; MYBL1; ZNF573; CBFA2T3; IRF6; MYB; FUBP1; ESRRG; CHD7; SAP30; ERG; WT1; IRF8; E2F5; KLF2; TFAP2C; ZNF117; KLF4; ZNF331; TOX3; TXNIP; SPIB; BNC1; MAF; ST18; ZNF165; THAP11; ZBTB18
Down-regulation 94 KLF5; YAP1; TSC22D1; IRF1; RNF10; NFE2; RNF14; RERE; RELA; HOXB7; KLF13; BCL11B; RFX5; RNF6; NRIP1; UBP1; HMG20B; FLNA; ADNP; TOB1; CEBPB; SALL1; SUV39H1; FOSL2; TSC22D2; HOXB13; YBX3; ZNF14; ERBB2; TRIM28; PREB; DNAJC1; SCAND1; TAF10; CARM1; RFXANK; MECOM; ID1; ZNF468; DLX5; BCLAF1; NRBF2; MEIS1; DAXX; CREG1; NKX3-1; ZNF266; MSX1; ZNF419; MEN1; ZMYM2; TRIP6; DDIT3; EMX2; ATF4; BIRC2; EGR4; NPAS2; ATF5; CUX1; ELF1; EZH2; PSMC3; TAL1; ZNF281; SUZ12; DPF2; BAZ2B; MED1; ELF3; YWHAB; TBL1X; TAF1D; HMGB1; BRD2; RUNX3; BRD8; STAT1; LPIN2; SLC2A4RG; ZNF586; BMI1; ENO1; AFF1; LEF1; ID3; IFI16; TFEC; ZBTB38; HLTF; BHLHE41; NR2F2; ESR1; NR3C1