Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09562 Linsitinib GSE70138 HA1E Human 24h 10uM EID0002
Types Number Response transcription factors
Up-regulation 132 KDM5A; IKZF1; NFKB2; PQBP1; RBBP8; MYBL1; ADRB2; TAF9; ZNF22; HMGA1; ARHGAP35; TBX2; RFC1; KAT2B; SMAD6; TXNIP; E2F5; SP140; NCOA2; ID4; TGIF2; ZFPM2; PEX2; ZEB1; AHR; FOXF2; SUPT4H1; THAP7; MED25; MEIS2; ZMIZ1; STAT2; TRIM22; PRPF6; COPS5; TFAM; VEZF1; MEF2C; TCEA1; NFAT5; HOXB5; SOX5; BPTF; ZNF124; SMARCD3; ZXDC; IRF9; HMGB3; PGR; ZNF292; HEY2; FUBP1; SAP18; CHD4; SATB1; MAGED1; SSX1; IRF7; PRDM10; TAF9B; CEBPZ; PAX5; HDAC9; CREB3L1; MXI1; HIC2; ZNF217; HOXB2; TOX; SIX3; ZNF512B; ZNF32; ARL2BP; NR3C2; KLF2; REL; SOX10; ATF3; ID2; ZNF611; HLF; POU2AF1; ZNF415; SOX18; ZHX2; AR; PLAG1; ZNF224; ZNF83; MED14; JUP; ZNF91; ZNF232; TCF7L2; ZBTB44; ZBED2; ZEB2; ZNF710; SPDEF; NFATC4; ZNF117; ZNF665; NR5A2; STAT4; ZFP36L1; TAL1; SOHLH2; ZNF160; SOX13; BACH2; VPS72; SPIB; WT1; OSR2; PRRX1; ZIC3; EN1; KLF3; SNAI2; TCF21; INSR; CBFA2T3; FLI1; TFEC; ZNF165; LIN28A; TFAP2C; ARNT2; PEG3; LEF1; ERBB4; ZNF586
Down-regulation 62 CCNE1; HIF1A; CENPF; HOXC10; HOXC6; EDF1; TSC22D2; CIZ1; BCL11B; WWTR1; TCEB2; BAZ1B; ZNF189; NKX3-1; NR1I2; POLR2A; NFYC; MBD2; JUNB; FOSB; ORC2; AIP; HOXB13; USF2; BIRC2; SSBP3; LZTS1; FLNA; TSC22D1; MLXIP; RYBP; CBX4; IRF2; SLC2A4RG; RFX5; MAF; PIR; CREB1; MAFB; TOB1; ISL1; DDX5; YWHAB; JUND; AFF1; DPF2; HTATIP2; INSM1; CITED2; CUX1; FOXC1; RUNX3; TADA3; IFI16; ENO1; BHLHE41; HES1; KLF4; TLE4; THAP11; PPARG; NR3C1