Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09558 Ruxolitinib GSE70138 HA1E Human 24h 1.11uM EID0002
Types Number Response transcription factors
Up-regulation 106 SUV39H1; HDAC6; RBFOX2; ZBED4; PHOX2B; MECOM; TTF1; HMGXB4; HMGN3; RBPMS; ZNF264; NR2C1; GATA2; KLF5; TAL1; THAP10; SMARCB1; MTF2; HSF2; ZNF552; ZNF580; RLF; HOXD1; CTBP2; TSC22D1; CEBPZ; TFCP2L1; MBD2; CIITA; KLF7; HLX; NKX3-1; PHIP; ISL1; NFIX; ZNF136; REL; ZBTB18; TFEC; HOXB13; REPIN1; KDM5D; MNDA; RREB1; NR4A2; HIRA; FOXM1; MED24; EYA1; TOX; HOXD3; NR3C2; ZNF302; NR4A1; SAP18; SNAI2; TDP2; TOPORS; ZNF426; SIAH2; HAND1; TCF7L1; IRF2; CERS6; CREB3L1; EMX2; THRA; ATF3; NR1H3; TCF21; SATB1; TOB1; ZNF652; ARNT2; MYT1L; KLF6; ZNF721; TLE4; ID1; ZNF165; ZFPM2; ZNF467; PRDM2; MAGED1; CRYM; ID3; PBX1; ZEB2; BHLHE41; ERG; PBX3; LEF1; TFAP2C; HOXC6; ZNF415; ST18; AEBP1; MEIS2; ZNF423; TCF7L2; SIX3; TBX3; IRF6; TCF4; ZNF586; WT1
Down-regulation 48 TP53; HMGA1; SPEN; ZIC1; SF1; HOXB2; TCF3; SHOX2; SOX9; MAZ; RELA; YAP1; WHSC1; TEAD4; CERS4; STAT3; HNRNPD; PDLIM1; ARID5A; DNAJC1; CRY1; NR1I2; BHLHE40; PBXIP1; TRIM29; TAF10; ACTL6A; SIX1; EYA2; IRF7; NKX2-2; FOXG1; YBX3; FOXC1; NR2F1; MAFB; DEK; SLC2A4RG; TRIP6; THAP11; ETV5; MSX1; BACH2; TRPS1; NR1D2; ESR1; TRIB3; NR3C1