Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09550 Alpelisib GSE70138 HA1E Human 24h 10uM EID0002
Types Number Response transcription factors
Up-regulation 41 HDAC6; BRD3; ARID4B; FOSL2; PHF2; TGIF1; RCOR1; RERE; ETV5; MAX; BRD8; SPEN; FOXO4; NFYC; SP2; PBRM1; EMX2; BAZ1A; MLXIP; NEDD8; SOX4; SUB1; FOXJ3; MYC; MAGED1; ELF5; HOXA10; ZMYM2; IFI16; PRKDC; CHD7; BCL3; SATB1; YBX3; RUNX1; TADA3; HOXC6; AFF1; ZBTB18; THAP11; IKBKAP
Down-regulation 111 MMS19; NFE2; PITX1; CDX1; HOXB9; HOXB6; EGR1; GATA1; RBPMS; SMARCB1; BARX2; CDX2; PLAGL1; KLF1; TGIF2; FOXA2; NKX3-2; HNF4G; RARG; JUN; TRIM29; PAX6; LYL1; KLF4; MYCN; BHLHE40; PROX1; NHLH2; ID1; ZEB1; SOX21; HAND1; HDAC9; CREM; SMAD5; E2F5; ZNF253; JUP; SOX18; NR3C2; ZIM2; PEG3; DNMT3B; ATOH1; SIX3; ZSCAN31; HIC2; SSX1; VPS72; TDP2; TWIST1; ZSCAN18; ATF3; JUNB; LIN28A; PDLIM1; POU1F1; ZNF91; REL; ZNF415; FOXF1; KLF5; TAL1; EPAS1; NR4A3; MAF; MEIS1; SAP30; TBX3; PRDM14; ZIC3; OSR2; ZNF665; HIPK2; MYB; EHF; ESRRG; FOXF2; SNAI2; ZNF165; DACH1; ST18; TRIB3; ZNF423; NKX2-2; IRF4; IRF6; HOXB2; INSM1; HIRA; EN1; MECOM; TCF4; TOX3; NEUROD1; ZNF467; ZIC1; CEBPA; TRPS1; SPDEF; HEY1; SSBP2; ESR1; NFKB2; ID3; ZNF586; NANOG; ERBB4; PPARG; MEF2C; WT1