Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09453 Nvp-aew541 GSE70138 HA1E Human 24h 0.12uM EID0002
Types Number Response transcription factors
Up-regulation 601 RELB; SUV39H1; KDM5A; NKX2-1; STAT3; KDM5B; ZNF22; HLF; PHF8; TCFL5; FOXN3; TBP; SMAD6; NR2F1; MXI1; ID4; MKL2; ID1; CRYM; TAF4; ZNF556; BCL3; FOXO4; ZNF696; MTA1; NLK; ZNF672; ZNF358; LHX6; POU2AF1; HMG20A; ERF; LHX2; EYA2; EPAS1; SETDB1; ZNF248; FOS; HNF4G; BRWD1; SERTAD2; ARRB1; KMT2B; CDX2; CRK; ZSCAN2; GFI1; SPIB; HDAC5; BRF2; SSBP3; ZSCAN16; PRRX1; ZNF639; SIM2; MED12; HR; ID2; VGLL4; PARP1; TCF15; CHD3; ZNF33B; ADNP; HABP4; ZNF195; ASH2L; HOXC4; ZNF350; ZNF112; PKNOX1; ZNF813; CREM; ZNF7; CUX2; TFCP2; ZNF212; NR1H3; E2F5; BAZ1A; NR3C2; DLX4; HMGA1; SSX3; RNF141; VSX1; BCL6; MYT1L; TAF1; FOXJ1; FOXG1; DLX6; TBX6; HDAC4; TFE3; CBFA2T2; IKZF1; TAF6L; SIX5; BATF; SIAH2; ID3; MYCL; TFEB; ZNF79; ZNF124; SOX12; TRIM24; MED14; LMX1B; ELF3; SNAI1; TSG101; BAZ2A; CALCOCO1; WWP1; E2F4; BRDT; TBX3; YBX2; ZNF135; ZNF223; ZNF444; ELK4; KMT5A; PBX2; MAML1; RBL2; MZF1; ATF5; ZNF557; HSF1; POU6F1; ZNF623; ZNF493; TP63; ZNF711; IRF2; HOXA3; ZNF574; STAT4; PRRX2; CIR1; ZNF646; IRF4; NCOA1; CIC; RBL1; BRD3; SIX1; ARID4A; POU2F2; ZNF250; TCF4; PITX3; LPIN2; FEV; PPARGC1A; TBX10; TUB; MYF5; PRDM8; ALX1; ZNF606; ZNF180; PIAS1; TBX4; MYF6; TRIP11; MYBL1; REL; ARHGAP35; ZFHX2; ZBTB32; ZNF225; GRHL2; MGA; NKX6-1; SF1; HOXC8; PATZ1; WHSC1L1; GCFC2; BCOR; SETD3; HDAC7; RNF111; KDM5C; SPI1; STAT6; TONSL; ZNF629; HCFC2; ZNF613; SFMBT1; BACH2; ZNF580; NFKB2; NR5A2; PAX5; MED25; CNOT1; MAP3K10; FOXA2; E2F8; PAX9; OLIG2; IRF5; TERF2; ZNF614; NRF1; PLAGL2; HOXB13; TAF4B; CBX7; ZEB1; ZNF282; BLM; EP400; CEBPE; NFX1; ZNF189; ZBED1; FOXE1; TEAD4; RSF1; DDX54; NFYB; PITX2; ZSCAN18; CEBPD; TRIM33; HIVEP2; MAPK8IP1; ARID3B; ZNF117; ZNF133; MEF2C; TERF1; SKIL; ZKSCAN3; ZNF276; TLX1; SMARCA2; HNF4A; UBP1; CCNE1; ZBTB3; SMAD9; PRDM2; SUPT6H; KLF13; NKX2-8; FOXH1; DAXX; ADRB2; NHLH1; NRBF2; ZBTB39; ZNF227; TCF3; ATOH1; TBX2; MDFI; RBBP5; TOX; ATF6B; TLE2; NR5A1; NR0B1; MAK; MYB; PBXIP1; FOXL1; EMX1; RXRA; ZNF174; CDX1; ZNF419; ARNT; RNF14; FHL5; CNOT3; MYOG; TDP2; ESRRA; MYOD1; TAF7L; LZTS1; ZNF701; CNOT6; NR3C1; TAF10; SMAD7; ERG; ETS2; TSHZ2; HIC1; IKZF4; NPAT; AGO2; ZNF814; SOHLH2; ASCL1; PIAS3; NR6A1; HMX1; EHMT1; PHOX2A; NFE2L1; ZNF141; ZFP2; ZNF184; NR1I3; ZNF287; ZNF143; DNAJC2; EHMT2; CREB3L2; ZNF257; ZNF41; SUPT7L; TBX5; HES1; EZH1; ZNF235; TBL1Y; NEUROD4; HOXC10; PRDM5; ZNF3; KLF3; NKX2-5; GATA4; SOX18; SMARCA1; HES2; YY1; ERBB4; UBE2L3; WNT4; SP100; REPIN1; MLLT10; MAZ; ZNF710; ZNF787; TAL1; ZNF671; TBX1; SSX1; SP4; ZNF107; IKZF3; IFNB1; CSDC2; TFAP4; PROP1; SHOX; ZNF45; SRCAP; NPAS1; MED20; ZNF232; TAF5; HOXC13; ZNF215; ZNF337; SATB2; KLF5; NFE2L3; BPTF; POU3F3; TLX3; SCAI; GRIP1; HIVEP1; ZNF14; FOXK2; DBP; ZNF544; RFX1; TULP2; ZNF75D; ZNF770; KLF12; SOX30; ZNF345; ZNF695; EGR4; DOT1L; VAX2; MNAT1; ELK3; PAX7; BTAF1; FOXF2; MAML3; NR4A2; ZNF768; PEX2; RCOR1; OSR2; KAT2B; ZNF415; DACH1; USP16; HOXD10; THAP9; PSPC1; NFE2; ZNF165; POU3F4; ZNF688; CREB3L1; NEUROG2; OVOL1; EYA1; CENPB; YEATS2; IRX4; EGR3; CBX2; ASXL1; ONECUT2; TAF1C; ASH1L; HIPK2; TBL1XR1; GATA1; CAMTA1; MLXIPL; ZBTB7C; ZNF778; SMAD4; TEF; CBX8; SND1; NR2C2; ZNF354A; MXD4; ZNF550; FOXD2; KLF1; ZNF667; TFDP3; ZNF286A; ZNF93; TRIM32; PRDM9; NEUROD1; OVOL2; MYEF2; LHX1; HEY1; SOX4; NFKB1; ZNF154; ZNF85; TEAD1; HOXB8; ZNF512B; SLC2A4RG; PPARG; ZBTB44; TTF2; ZNF221; SOX14; RNF2; HMGB3; ZNF80; DMRT1; POU6F2; HSF4; RNF10; HESX1; CARF; RCOR3; PHOX2B; ZNF529; CALR; ZNF253; NFAT5; NFATC1; BCL11A; ZNF652; FOXD3; KLF10; PAX1; TCF21; MECOM; RFX7; ATF7; ZNF234; ZKSCAN4; SOX21; ZNF571; HIC2; ZNF157; ZNF674; ZNF407; NEUROD6; WDHD1; ZBTB48; CD3D; TGIF2; ZNF281; SOX2; ZNF214; L3MBTL1; RARB; NR4A1; ZNF492; ZNF155; UBE2B; ZNF532; SPDEF; PROX1; SMARCC2; ETV3; MEOX1; BHLHE40; ZNF208; GATA2; POU2F1; GCM2; ZNF682; ZKSCAN8; TULP4; ZFP69B; DCC; CIITA; ZNF81; SIX3; PRDM10; ZFY; SRY; ZKSCAN7; ZNF780B; ACTL6A; ARNT2; FOSB; ZNF10; TSC22D1; PRPF6; BRCA2; PRDM1; DNMT3B; NCOA2; ZNF236; SUPT3H; TRIM22; ZNF132; PAWR; PAX4; GATA6; BMI1; FOXJ3; SSX7; ZNF665; AEBP1; TCF12; ZNF551; THRB; VEZF1; IFI16; SOX13; SOX11; BRD4; NANOG; LIN28A; FOXA1; EGR2; PBX1; TSC22D4; TRPS1; LMCD1; EHF; RUNX3; CHD7; IRF9; ZNF467; HOXD1; CEBPZ; ZNF589; SMAD1; MAGED1; ZHX2; SATB1; LEF1; IRF6; FOXF1; KDM5D; CEBPA; NR1D2; E2F2; KLF4; SSBP2; ZNF586; MEIS2; TXNIP
Down-regulation 183 DNMT1; HMG20B; HOXA5; GMNN; CCNA2; ENY2; HOXB6; EWSR1; ZZZ3; SIX2; GATAD2A; ADNP2; CBX3; ATF4; MITF; APEX1; DEK; SHOX2; FOXO3; CAPN15; CCNC; UBE2I; SAFB2; WWC1; BIRC2; SMARCB1; NFKBIA; BCLAF1; HDAC3; CNBP; PCGF1; C1QBP; CERS6; PMF1; HOXB5; YBX1; TRIM29; ITGB3BP; MED1; YBX3; NPM1; FLNA; PTRF; RBFOX2; JARID2; YAP1; BTF3; TULP3; KLF7; CITED2; HNRNPD; CXXC1; ATF1; TSC22D2; HOXA11; THAP4; NACA; MNT; SMARCE1; TOX4; SP3; ILF2; PURA; ARNTL2; ZEB2; ZNF266; CCNH; HMGXB4; HOXB7; ZNF146; ZIC1; ING3; CNOT2; ZFP36L1; ABL1; SMARCA4; PLAGL1; YWHAB; HTATIP2; TCEB2; RUVBL2; TFDP1; CDK7; MED24; CENPF; BRD8; KLF11; XRCC6; CRY1; HIRA; HOXB2; ERBB2; TADA3; RREB1; SFPQ; CDC5L; PUF60; NEDD8; MED27; CREB5; PFDN5; CTBP2; TRIP6; CHD8; EDF1; ERCC3; FOXM1; BCL10; ZNF83; MTDH; CARHSP1; BHLHE41; PDLIM1; ZNF593; TRRAP; JUND; RNF138; RBBP4; ST18; DDX5; HMGN3; ZNF562; RFXANK; PTTG1; TOB1; NR1H2; FOXD1; BRD2; ISL1; CBX6; NR2F2; GTF3A; ZNF468; ARID1A; GTF2IRD1; ZNF573; TGFB1; PCGF2; SREBF1; MAFF; TLE1; KMT2A; POLR2A; SALL2; RAN; TLE4; MED23; RYBP; MYRF; ZMYND8; PHF20; DDIT3; AR; MNDA; BRPF1; NRIP1; ZBTB38; KLF6; ZNF430; POU4F1; MAFB; TAF5L; PEG3; HOXC6; INSR; ZNF426; RORA; HDAC1; ZBTB20; BNC2; PBX3; MEIS1; ENO1; ZNF91; WT1; THAP11; RFX5; STAT1; WWTR1; ATF3; MDM2; HLTF; TFEC