Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID09429 Vemurafenib GSE70138 HA1E Human 24h 0.12uM EID0002
Types Number Response transcription factors
Up-regulation 645 RELB; EGR1; DBP; KDM5A; BPTF; HMGA1; GATA1; UBE3A; NKX2-1; POU2AF1; MZF1; SMAD6; CREG1; BHLHE41; SSBP3; ATF6B; PLAG1; HMG20A; NR2F1; BRCA1; LHX2; CHD1; ZNF217; GFI1; TP63; MMS19; CASZ1; PEX2; EZH1; ZNF629; ONECUT2; ZNF408; KDM4A; NFATC1; DLX4; CNOT2; USP16; LEF1; EP400; IL16; TRIP11; MAF; HOXC4; RNF111; ZNF75D; HOXC10; ETV7; NFE2; EGR2; BAZ2A; MED12; NCOA2; PITX2; ZBTB40; TRRAP; BTAF1; FOXE1; CIR1; NFX1; HR; NRF1; PAX5; ZNF671; ID4; LYL1; HEYL; RSF1; HOXD3; IRF4; TRPS1; RFX2; POU3F3; ARNTL; FOSB; NEUROG1; TFAP4; ZNF688; LMX1B; DYRK1B; TBL1XR1; CHD4; SAFB; MNDA; LHX3; TFAP2B; FOXJ1; ZNF556; GCFC2; KLF1; CBX7; CALCOCO1; HOXD9; TRIM24; ZMYND8; MYB; ZNF623; PRDM1; ZNF672; PAX7; BRCA2; EWSR1; TCEA2; WWP1; TLX2; GBX2; ZNF324B; ZNF446; PIAS1; E4F1; RUNX2; E2F8; ZBTB48; RORB; HDAC4; GATA3; ETV6; RXRG; RORA; PHOX2A; POLR3F; PAX1; CEBPE; ZNF304; ZNF536; CCNT1; PROP1; KDM4C; KLF15; BATF; TUB; MAPK8IP1; SIX3; AIRE; RREB1; HNF1B; ZNF335; CREBZF; NPAS1; ZSCAN5A; TAF4; EGR3; ZNF557; SOX21; TERF1; KDM5C; CAMTA2; ZFP30; ZBTB7C; ZNF22; ZBTB25; PAX3; ZNF771; SERTAD2; ZSCAN18; ZEB2; BLM; E2F5; HSF4; VAX2; FOXC2; NEUROD2; KLF10; USP21; BTG1; ING3; HOXC5; CBX2; TCF7; TDRD3; RFX1; SOX2; HOXC8; SCRT1; FOXG1; NLK; TTF2; AFF3; HOXA11; REPIN1; PML; TEF; ZFP36L2; DLX6; ZKSCAN4; PITX3; MAP3K10; NKX2-8; LHX6; NR5A1; FOXH1; ESRRB; MDM4; ATF7IP; ARID4A; HIPK2; CBX8; ZNF257; MBD1; PRDM14; HIVEP1; LHX5; PRDM16; ZNF215; BRD2; EHMT1; SMARCA2; CRYM; TULP2; PPRC1; FOXD3; NKX2-5; JUNB; ZNF235; TAF4B; PBX1; ZNF770; SRY; SOX1; ZNF528; IRF5; TAF1; OVOL1; EP300; TBX4; BRDT; ZFP64; THAP3; NEUROG2; ZNF221; ALX4; POU6F2; NR2C1; HMX1; PRMT2; POU2F3; CHD3; DMRT1; CEBPA; DOT1L; PRDM12; SPI1; ZNF282; KLF8; GRIP1; ZNF286A; SP100; EGR4; ZNF33B; ZBTB3; ETV3; ZNF253; ATF7; IKZF4; HAND1; PRDM8; ZNF250; VGLL1; CARF; HOXB1; SUPT6H; ZXDC; IKZF3; KMT2A; ZNF197; ZBED2; CDX4; AEBP1; EYA2; STAT4; BARX2; SOHLH2; ZNF835; TBX5; IRX4; SOX18; ZNF512B; TGIF1; ZFX; CD3D; CHD2; FOXN1; FOXN3; HLF; ZNF701; CALR; IFI16; BCL11B; SHOX; MGA; TGS1; AFF2; MLLT1; ZNF16; SMAD1; KLF4; SSX3; ZNF816; ZNF419; ZNF174; ZNF813; ZKSCAN3; LDB1; ZNF442; ZSCAN16; PRRX1; THRAP3; HOXC11; TFDP3; ZHX2; HLX; ZIM2; TLE4; KLF9; ASH1L; HIPK1; CITED1; TBX1; MYOD1; GATA4; BACH1; NEUROG3; PRDM9; TLX3; NCOA1; MED25; SOX12; STAT2; ZNF41; SPDEF; GCM1; ZNF225; TULP4; ARID3A; BLZF1; ZSCAN32; IKZF5; APBB1; HOXA3; MNX1; HOXD12; BCL11A; SOX13; CIC; FEV; BACH2; ASH2L; PHOX2B; ZNF749; NR2C2; NFKB1; POU3F4; ZNF778; TBL1Y; ESRRG; FOXI1; CIITA; MYEF2; ZNF107; HES2; ZNF3; ZNF695; BRWD1; SMAD9; FOXB1; HOXD13; TAF5; HOXD10; WT1; NFE2L2; MYCL; ZNF189; HMGXB3; CBFA2T3; ZNF34; PRDM5; ING1; EMX1; NR0B1; RFX7; NEUROD4; EYA3; ING4; ZNF132; ARID3B; ZNF415; FOXD1; ZNF506; PPARA; THRB; MYCN; ZNF266; NR6A1; TFEB; ZNF500; TFDP2; NRL; PDX1; CBL; ARID5A; POLR2A; PPARD; SATB2; CUX1; SP140; ZNF444; ZNF343; ADRB2; TULP1; IKZF2; NPAT; IFNB1; STAT5A; CITED2; ZNF93; HOXC13; POU3F1; ZNF814; PNRC1; MYOG; MKL2; ZNF493; SNAI1; ZNF287; ONECUT1; ZNF467; ZNF613; SMAD4; SSX1; ZNF211; TBX10; RNF14; CHAF1B; TCF4; POU6F1; ELF1; SPIB; GCM2; PBX2; ZNF549; THAP9; POU4F3; HOXD1; TGIF2; ZHX3; SOX14; ZNF157; ELF5; ZNF532; PRDM2; ZNF516; EBF2; ZNF112; MBD4; ZNF471; BCL10; WHSC1L1; TRIM22; RNF2; ZNF236; NR3C1; DLX5; GTF3A; POU1F1; TCF15; RARG; GTF2I; NR1I3; FOXF2; GLI2; ZNF682; NFIX; WNT4; TAF7L; ZNF329; TCFL5; GSC2; ZNF154; HESX1; ZNF460; OLIG2; ZNF214; ZNF710; IRF2; SMAD7; ZNF674; MAML3; ZNF711; EPAS1; HOXB8; FHL5; ZNF80; ETV5; PRDM13; ZNF222; UBE2B; VDR; ASCL1; NR1I2; RNF6; ZNF552; ZNF492; YEATS4; MSX2; TBR1; JAK2; ZNF407; ID2; ZNF254; SP4; FEZF2; CDX2; TP73; DCC; SIM1; RARB; FUBP1; SOX5; CCDC59; TFAP2C; NFYC; SSBP2; PRDM10; INSR; KLF13; ZNF550; ZNF391; SNAPC4; ETV2; MAFB; VPS72; SSX7; RFX3; SMARCD3; FOXM1; MEOX1; IRF7; TFAP2A; ZFP2; ERBB4; CSDC2; FLI1; IRF9; MEF2C; HCFC2; ZNF81; VHL; PAX6; ZNF32; ZBTB44; ZNF165; POU4F2; FOXO1; ZNF124; ZNF7; BMI1; PROX1; SAP18; MDM2; ZNF141; HOXA2; ZNF345; FOXE3; SCAI; C1QBP; ZNF195; TFCP2; ARNT2; ZNF135; BNC1; BARX1; OSR2; ZNF208; SNAI2; PAX9; ELK3; RNF10; CNOT3; NFATC4; TOPORS; HOXD11; ZKSCAN8; PPARG; TBX21; LIN28A; HEY2; ZIC3; NR5A2; NR4A2; TRIM32; PIR; ZNF177; SUPT3H; SALL1; TAL1; CBX4; THRA; ZNF667; ZNF440; ZNF394; MEIS2; MYT1L; ZNF331; TRIP6; ZNF675; MLXIP; MEOX2; MED13; BBX; MYF6; NEUROD1; ZNF10; MAGED1; ZFP36L1; ZNF780B; HEY1; ZNF606; TXNIP; SOX11; TCF7L2; OVOL2; ZNF273; ZNF665; MED14; ARID5B; AHR; KLF6; RUNX1; DACH1; CREM; TWIST1; ZNF586; EN1; BAZ2B; ZNF544; ZNF551; SATB1; IRX5; KLF2; ATF3; NANOG; FOXF1; KAT2B; IRF6; ID1; KDM5D
Down-regulation 155 CRK; GMNN; HOXA5; NPM1; HOXB6; CBX3; SSRP1; WWC1; TSC22D2; HDAC6; RBBP8; ATF1; FOXC1; UBE2L3; SIX2; PCBD1; DEK; PITX1; FLNA; ZBTB11; PURA; NAB1; WWTR1; LOXL2; TEAD1; MED15; NELFB; APEX1; VEZF1; SUZ12; YAP1; HOXB5; TCEB2; HIF1A; GATAD2A; ITGB3BP; ZBTB20; EDF1; ZNF91; SIAH2; NFATC3; NFIB; HTATIP2; SUMO1; SIN3B; TULP3; CARHSP1; HDAC1; CEBPG; FOSL2; UBE2I; ZBTB38; MED21; RUVBL2; PQBP1; JUND; PCGF2; TADA3; ZNF468; ZNF443; EZH2; RBFOX2; RFXANK; CCNC; PTRF; ZNF44; SMARCA4; NEDD8; NKX3-1; TCF25; MAX; SMARCB1; SMARCA5; FOSL1; LITAF; PDLIM1; KAT2A; THAP7; CDYL; TRIM28; HMGN3; PTTG1; NONO; ABL1; ENY2; LZTR1; YBX1; E2F3; NCOA4; BHLHE40; CSDE1; TAF10; MED6; BATF3; RHOA; COPS2; PSMC3IP; CIZ1; BANP; BIRC2; YWHAB; SUPT4H1; LHX1; RBPJ; ERBB2; TMF1; ENO1; NR2F2; HSBP1; NR2F6; RYBP; HOXB2; ZKSCAN1; ZNF432; NCOR2; TFCP2L1; ZNF160; CTBP2; AIP; CEBPB; BTF3; PSPC1; XRCC6; CDC5L; ETS2; NR4A3; CBFB; CREBL2; MITF; PUF60; ING2; SUB1; HIRA; SPEN; TCF7L1; STAT1; SOX9; TGFB1; ZMIZ1; HOXB7; SMARCC2; SMARCA1; LPIN2; EHF; SIX1; TOX3; ATF4; HHEX; PBX3; ZNF611; INSM1; ERG; IKZF1; SAP30; TRIB3