Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08897 Mitoxantrone GSE70138 HA1E Human 24h 3.33uM EID0001
Types Number Response transcription factors
Up-regulation 382 NFIX; IKZF1; NFKB2; RFX1; MEF2C; PSMD9; THRB; E2F2; ALX4; HIF3A; ZNF154; CREG1; HOXC5; MYCBP; HEYL; HDAC5; PAX7; HOXB1; SRY; ATN1; SOX21; ZNF117; MECP2; NEUROG2; PROP1; MAML3; NEUROD4; NFATC4; DLX6; OVOL2; SIX3; ZNF556; HAND1; SOX3; POU3F3; HES2; ZNF606; THRA; HOXB8; ZNF211; ZNF467; NR2E1; TULP1; ZNF771; ZNF551; SOX5; PDX1; TBX6; SCRT1; TFDP2; ZNF544; POU6F2; TAF6L; MED25; SOX2; CREBL2; AR; PRDM12; GBX1; NEUROD2; PAX1; PRDM14; HSF4; ASCL3; SOX18; ZNF264; LZTS1; CARF; CDX4; EMX1; ZNF562; SHOX; DOT1L; DCC; ZXDC; ZNF695; ZNF778; HOXC8; NOCT; ZNF688; TBX21; VENTX; ATOH1; EP300; ZKSCAN4; RNF141; ZNF550; TBX1; LHX3; FEZF2; TAF4B; VSX1; ZBTB44; ESR2; ZNF75D; ZNF440; CD3D; ZNF814; ZNF669; HIPK2; NHLH2; IRF6; BCL11A; ZNF816; HAND2; REL; DBP; SRCAP; TCF4; KLF15; NR5A1; TP73; FOXH1; ZNF611; RORB; L3MBTL1; DLX4; ONECUT1; PRDM9; ATF6; LDB1; FOXD3; LHX6; LMX1B; HOXA3; PPARGC1A; HOXD3; TEF; CHD2; ZNF701; ZBTB7B; ZKSCAN3; GBX2; ZBTB7C; ZNF10; SCAI; CBX2; ZFHX2; ZNF358; RBFOX2; RBPJL; HIVEP3; ZNF711; MAK; HESX1; KMT2D; OVOL1; PAX3; TLX3; NKX6-1; SPI1; ZNF419; FOXJ1; TLX1; ZNF224; KAT2B; TUB; PRDM2; GCFC2; FOXB1; ZNF304; ZNF132; ZNF44; NEUROG1; IKZF2; TWIST1; BRDT; TOX; MAPK8IP1; CALCOCO1; RFX3; FOXF1; NR1I3; ZNF235; NR4A2; TSHZ2; NRL; IKZF3; ZNF8; EHMT2; MZF1; ZNF532; VGLL1; NEUROD6; ZNF549; ZNF835; PKNOX2; ZNF667; TBX10; NPAS1; ZNF586; TAF12; NHLH1; WNT4; RFX2; ZNF391; ING4; NKX3-2; ZNF682; SSX7; MED12; CIITA; PHOX2A; ZNF529; EPAS1; ARID3A; DLX5; NFAT5; MXD4; ATF7; ZIC3; GATA1; ZNF528; RARG; SSBP3; FLI1; ALX3; KLF7; HEY1; ONECUT2; MED31; SUPT4H1; TAL1; ZNF273; ZNF124; MLLT1; AFF2; EBF2; ZNF493; ACTL6B; POU2F3; STAT2; NR5A2; ZFP2; PLAGL1; SMAD6; HOXD1; TAF9B; CRTC1; ZBTB48; ZNF362; SIX6; ZNF345; RSF1; HBP1; ZNF226; TXNIP; BARX1; DMRT1; YBX2; HMGA2; TFAP2A; PHOX2B; NFIC; CALR; ZNF195; PRDM1; HOXA2; SOHLH2; KDM5C; TAF6; CDX2; ESRRG; HMGN3; SSX3; FOSB; ZNF334; SLC2A4RG; IRX4; MTA2; LYL1; ZNF253; GRHL2; ZNF665; HOXB13; ZNF623; PBXIP1; ZNF350; SPDEF; MDM2; LIN28A; SKIL; SKI; KLF1; ZNF223; HMBOX1; NFATC1; BCL6; SAP18; MEIS2; CNOT3; ZNF710; NR0B1; CERS6; NR4A1; PEG3; CBX7; ERBB4; GLI3; MXI1; SOX17; TRIM22; TCF21; SALL2; SP140L; ARNT2; YBX3; HIC2; ZNF587; IRF1; JUP; EYA1; GFI1; MSX1; NR4A3; INSR; PEX2; RNF14; ZNF423; ZNF426; NR1I2; ZNF136; MECOM; PBX1; AES; TCF7; CTNNB1; PBX2; HDAC9; KLF13; CREM; ZFHX4; TDP2; ZBED2; ZNF331; ZNF536; GTF3A; NR1H2; HLTF; HLF; TCF7L1; WWTR1; TOB1; MAF; PITX1; SIM2; SOX13; ZNF160; NR2F1; SMARCA1; FOXF2; MYCL; LEF1; ZNF721; CUX2; EMX2; HES1; MYCN; HDAC4; NANOG; NFE2; SHOX2; LITAF; TRPS1; FOXL2; ZNF652; TRIB3; SOX11; FOXO4; AEBP1; ATF3; TGFB1; ID3; HMGA1; MNDA; ID1; ZSCAN18; GATA2; PAX6; IRF8; MEIS1; WT1
Down-regulation 210 FHL2; CCNA2; FOSL1; PUF60; USP22; PAX8; UBE2I; NFKBIA; XBP1; ZNF146; NFIL3; EED; NRIP1; HNRNPD; HOXA10; SNW1; MED1; ECD; HOXA5; FOXO3; TBP; NUP62; RBM14; PPRC1; ZBTB11; ZNF263; ADNP; SMAD3; ERBB2; TAF5; AATF; CCDC59; CDK7; MED17; TRIM16; BRPF1; VEZF1; TAF9; SCAND1; SUV39H1; EZH2; TP53; MYBL2; ARID5B; MYC; FOXJ3; AIP; TRIM32; PATZ1; SUZ12; MBD2; CIZ1; DDX54; IKBKAP; RNF111; PRDM4; RELA; ARID4B; CRY1; ZNF217; ATF7IP; NR2F6; CTCF; BASP1; ZNF410; KMT2A; SOX4; NPAT; PREB; BRD3; PRPF6; ZMIZ1; KAT8; NCOA6; ATF1; MED6; PCGF2; E2F6; CENPF; HOXB6; BMI1; ZNF84; CEBPZ; ZNF574; BRCA1; MGA; HOXA11; ADNP2; RLF; SF1; SSRP1; ZBTB1; MYBL1; NFKB1; CENPB; HOXB7; CNOT1; FOXD1; BCLAF1; PHIP; BAZ1A; SMARCE1; CREB3L1; CHD8; NELFB; DEK; ZMYM2; APEX1; TLE1; ERCC3; ILF2; SMARCA5; RUNX1; CAPN15; RYBP; ZNF266; ING2; BCOR; MTF2; BRD7; RNF138; ANKRD1; REST; ATF4; SFPQ; KLF6; BAZ1B; TMF1; RAN; RBM39; ZNF200; SMAD7; HSF2; CDC5L; SETD2; DNAJC2; IRF7; CEBPG; TRIM28; KAT7; ZBTB18; NPM1; CEBPB; PQBP1; PHF20; EDF1; CNOT6; CARM1; RBPJ; CBX3; ZBTB24; CHD1; UBP1; PURA; PTTG1; MTDH; JUND; ZNF593; ELF5; TSC22D2; BTG1; WWC1; FOSL2; TRIM27; BATF3; UBE3A; SP100; YWHAB; RCOR1; FOXE1; SMAD1; STAT6; ASXL1; AFF1; TBL1X; ZNF131; PTRF; ZNF281; TADA3; JARID2; BRD8; CREB1; ELF1; TCEB2; COPS2; CTBP2; CRK; TOX3; TCF12; SUB1; PAWR; BHLHE40; SP110; TGFB1I1; KDM5D; SOX9; DNMT3B; SERTAD2; ZBTB38; FOXC1; EGR3; HOXB2; HMGB2; HOXC6; ELK3; SATB2; NR2F2; NFATC3; NR3C1; SSBP2