Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08867 Alpelisib GSE70138 HA1E Human 24h 0.04uM EID0001
Types Number Response transcription factors
Up-regulation 257 SUV39H1; TCFL5; MEF2C; RELB; NRBF2; ING1; EGR2; MED14; YEATS4; ZNF45; TTF2; ZHX3; HES2; SRF; AFF3; HIVEP1; NFE2L3; WDHD1; STAT2; ZNF764; TFDP3; LIMD1; TAF1A; ZNF180; SUV39H2; NFATC1; CASZ1; DMRT1; BRCA2; ZNF576; ZNF532; ZNF574; CBX7; FOXE1; IKZF3; MAGED1; BCL3; ZBED4; GFI1; FOXD3; MTA2; PLAG1; ZNF324; NRF1; NR1H2; ZBTB3; TAF1; ZNF510; HOXA1; MYB; SUPT4H1; TFEB; RBL1; SATB2; CEBPZ; CENPB; PLAGL2; FHL5; PRDM5; CDYL; ELF4; BNC1; POU3F4; E2F8; MLLT10; WHSC1L1; FOSB; ZNF236; ZNF571; POU2F3; ZNF337; PAX4; POU1F1; SSX3; ZNF165; HES1; PCGF3; ZBTB25; ZNF460; ZNF184; SPIB; IRF8; GATA6; BMI1; FOXJ2; RUNX1; ZNF623; KLF4; AFF2; CBX6; ASCL2; SCRT1; ERF; TLX3; GATA4; KDM5A; BRWD1; ZNF507; FOXO1; BRCA1; ZNF516; TFAP2C; ZNF222; ZNF134; RFX2; WHSC1; ZFP69B; MED4; GCM2; TBX21; BRDT; BLZF1; FOXA2; TCF4; TCF21; CSDC2; ELF3; ELF2; TLE2; ZNF710; SMARCA2; ID1; SOX13; SKI; SAP18; TEAD1; ZNF701; ADNP; MECP2; PPARG; RING1; ETS2; ZNF200; OVOL1; ZNF473; SIX3; ZBTB39; BARX1; TSG101; ZNF587; ZBTB6; SERTAD2; PPP1R13L; ZNF674; REL; MYT1; LHX3; ARL2BP; NR3C1; ZNF492; SPI1; ZNF350; PIAS2; SETD2; ZNF432; ELK1; TDP2; KLF5; ZNF225; SOX12; ZNF215; ARID3A; NR3C2; CNOT2; ZNF267; IRF1; EGR3; BRD2; ELF1; MED27; RNF6; L3MBTL1; TGIF1; ZNF32; ZNF14; PATZ1; TEAD3; ZIM2; ZNF141; NR1D2; DDX5; ZNF131; GATA2; NR1I2; REPIN1; HDAC9; TFCP2L1; ZNF112; MNAT1; BCL6; NFYA; ZNF7; ZMIZ2; MDM2; PITX2; ZBED1; TSC22D1; NPAS2; ANKRD1; NR2F1; URI1; NKX2-2; ZNF410; HIC2; ZBED2; ASCL1; MED13; FOXL2; CTNNB1; IRF6; NCOA1; JAK2; SMAD3; ZNF226; TP63; EPAS1; BTG1; PIAS3; ZNF239; PCGF2; PBX3; FOXA1; HDAC4; RUNX3; SNAI2; DAXX; ID4; BACH2; BNC2; JUNB; ZNF536; NFAT5; RBBP8; TRIM16; NR1H3; JUP; ZNF415; LPIN2; CBFA2T3; PBX1; ID3; CREB3L2; ZBTB16; PIR; PAWR; OSR2; ZNF721; NR0B1; PAX5; AHR; ZEB2; NANOG; CREM; SATB1; LITAF; ZNF652; BHLHE41
Down-regulation 131 PARP1; NPM1; SMARCD1; JUND; CENPF; MSX1; PA2G4; STAT1; EYA1; MED21; PSIP1; KLF7; CARM1; PTTG1; TAF10; ITGB3BP; NR2F2; CBX5; DNAJC2; TCEA1; LEF1; COPS5; RCOR3; ZBTB20; RAN; CCNC; CBFB; NFYC; RBM14; TRIP4; MEOX1; ZNF266; BRD7; SALL1; CTBP1; ENY2; CDC5L; CNBP; SFPQ; MYCN; ETV6; MXD3; MTDH; TSC22D2; ZBTB11; HMBOX1; MBD2; CIZ1; SP110; PMF1; ZIC1; CARHSP1; PRRX1; ZFP36L1; ZNF281; PFDN5; NFATC3; NONO; CRK; GATAD2A; MED24; MAZ; RNF141; SMARCB1; C1QBP; SMARCC2; CBX3; TULP3; BAZ2B; HOXB2; RBM39; NFIB; FOXM1; YBX1; CD3D; CRY1; HDGF; PRMT2; MAF; RNF138; CHD7; HOXB6; TWIST1; NOC2L; DEAF1; CAMTA1; BASP1; FOXD1; SMAD1; CITED1; COPS2; KDM5D; YWHAB; TEAD4; FLNA; SUMO1; ZKSCAN1; CREB1; BATF3; MAFB; HOXC6; CTR9; PDLIM1; HLTF; SHOX2; SP140L; RFX5; HIRA; MEIS1; ZNF93; NFIC; TGFB1I1; YBX3; RBBP7; SIM2; ZNF91; TOX; SMARCA1; TADA3; PAX6; INSR; KLF9; PEG3; HOXD1; HMGB2; TRIM22; TLE4; ZEB1; ZBTB18; TRPS1; ELK3