Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08591 Canertinib GSE70138 HA1E Human 24h 10uM EID0012
Types Number Response transcription factors
Up-regulation 646 SPDEF; FOXO4; PPARD; THRB; SOX2; TP73; VENTX; NR5A1; ZNF695; CHD2; SCRT1; FEZF2; ZNF549; HIVEP3; ZFHX2; SIX6; ZNF682; TLX3; NEUROG2; ALX3; ASCL3; SPI1; TBR1; HIF3A; GBX1; IKZF1; POU4F3; GCM1; ZNF589; HOXD12; POU6F2; NCOA3; ZNF154; ZNF41; ZNF225; PRDM9; ZNF442; PRDM16; MEF2C; EMX1; TEF; PAX7; MLLT1; GRIP1; RFX1; ZNF816; TULP1; HESX1; ZNF75D; FOXB1; ZNF471; PRDM14; SOX14; ZNF484; LIN28A; BRDT; FOXD3; ALX4; FOXH1; ZNF221; RFX3; SOX3; SOX18; ZNF334; ZNF174; PROP1; ZNF391; ZNF142; DOT1L; MAML3; TULP2; ETV2; ZNF780B; ZNF132; ZBTB3; RORB; RSF1; GSC2; ZNF81; ZKSCAN8; ESRRB; ZNF778; HOXC5; VSX1; ZNF79; HSF4; ZNF155; ETV3; NR0B2; ZNF235; PDX1; ZNF74; SSX3; ZNF749; CDX4; ZNF688; GBX2; SOX21; E2F4; SOX1; TAF6L; ZNF44; ZNF34; ZKSCAN3; ZNF124; POU1F1; PAX4; ZFY; FOXN1; NKX3-2; NFATC4; ZKSCAN4; ZNF362; HOXB8; SP4; ZNF343; ZNF214; HOXD13; NEUROG3; ACTL6B; ZNF208; NR1H4; ARNT2; HOXB1; HEYL; UTF1; SIX3; LBX1; WHSC1L1; RBPJL; TBX1; TBX19; TFAP2A; ZFP69B; ZNF257; SRY; NEUROD4; GCM2; ZNF215; ZSCAN2; PCGF1; ZIC3; ZNF223; CBX2; FOXE3; HIC2; ZNF814; LHX3; TFDP3; ZNF480; NFKBIB; NEUROD6; LMX1B; ZNF80; ZNF141; PRDM12; ZNF407; ZIC4; AIRE; POU2F3; ZNF674; NEUROD2; ZNF157; ZNF234; PRDM2; ZNF550; TBX5; KDM5A; TBX6; SCAI; ZXDB; DCC; FOXF2; CBX8; ZFP2; ZNF324B; ZNF195; MSX2; SOX5; TAF4B; NANOG; ZNF675; HINFP; ZNF10; ETV6; NFIX; ZNF500; ARID3B; RXRG; RARG; CRX; FOXL1; TBX4; CIITA; RFXAP; HSF1; NEUROG1; ZNF224; SSX7; NHLH1; NR5A2; PAX1; POU3F4; MAP3K10; NACA2; MAPK8IP1; HMGA1; ZSCAN9; ZBTB44; FOS; ZNF345; ZIM2; ETV1; EN1; MYF5; ZNF669; NRL; PAX3; IKZF2; LZTR1; GTF2A1; ZNF254; EYA3; ZNF573; ZXDC; SMARCB1; TAF1; TONSL; TAF1C; ZNF239; GON4L; POU5F1B; ZNF835; PRDM8; ATN1; ASCL2; ZNF219; POU3F3; ATF7; ZNF623; ZBTB7C; EPAS1; ZNF507; ATOH1; ARHGAP35; PRDM10; KLF15; BARX1; VGLL1; ZNF331; HES2; DMRT1; SOX30; TULP3; TLX2; SSBP3; ZNF613; ZNF180; MDM4; VHL; HLX; ZNF440; GATA1; PRDM1; HOXA6; NEUROD1; VPS72; SALL2; HOXA2; ZNF286A; ZNF222; NR2E1; THAP9; NKX6-1; PITX3; CARF; TFAP2B; MED31; SOHLH2; CDIP1; ZNF701; NR4A1; ZNF250; HAND2; NKX2-5; ING4; ERBB4; KLF8; DLX5; STAT2; ZNF23; ZNF460; DLX6; CBX6; AFF3; SNAI1; MTA2; HDAC9; FHL5; ZNF415; SMARCA4; ZNF528; ONECUT1; POU6F1; ASH1L; MECP2; HNF4A; GMNN; MYEF2; MNDA; ZNF287; ATF6B; ZNF175; ZNF117; DLX4; RAX; IRF3; ZNF273; HOXA3; ZNF16; FOXP3; MED12; ZNF136; NR6A1; HOXC8; THAP7; SNIP1; POU4F2; TFAP4; MAFG; ZNF43; PPARA; ZNF253; NPAS1; SHOX; CRTC1; CBX4; ZNF667; CBFA2T3; PRDM5; CIR1; ETV7; SNAPC4; ZNF350; YBX2; CBFA2T2; HIC1; NR2C2; SOX11; TBL1Y; LYL1; TAF7L; IKZF3; ZNF35; TFDP2; MZF1; ZNF93; BCL11A; ARID3A; KLF1; TLX1; NOCT; PAX9; RBBP5; TSC22D3; SRCAP; HIPK2; ST18; HNF4G; FOXC2; SKIL; TSHZ2; SETDB1; CNOT3; CAMTA2; ZNF544; POU3F2; ZNF232; NFAT5; MYNN; MAFK; ZNF33B; E2F2; HDAC5; INSR; HMGXB4; EGR4; CCNT1; GMEB1; CEBPB; LDB1; ZBTB17; SIX5; NR4A3; RING1; ZNF580; SOX13; ZNF646; CERS4; ZNF227; TAL1; PAX2; TCF21; ZNF536; ATF5; ZNF85; RORC; ZNF665; SKI; TCEA2; ZBTB7B; HDAC11; TUB; CALCOCO1; ZNF671; KAT2B; TRIM33; ZNF45; FOXJ1; SPIB; TDP2; JAK2; FOXA2; TGS1; LHX2; CEBPE; ZBTB39; HNF1A; MEIS2; EP300; ZNF133; VAX2; CBX7; NAB2; KLF11; HBP1; ONECUT2; POLR3C; DDIT3; EHMT1; SHOX2; TFCP2L1; ZFHX3; ZNF473; ZNF91; PIR; CREBL2; TAF5L; ZNF557; GLI3; RARB; MXI1; IRX4; KLF13; THRA; ARRB1; IFNB1; AFF2; HOXB5; ZBTB16; SP140; ZNF423; ZNF354A; ZNF112; IRF6; ESR2; MTF1; SMARCD1; TFEC; ZNF384; ZNF710; ZNF770; HMGXB3; ZNF562; NKRF; TBX21; TRIM22; ID2; GTF3A; TCF7L2; MEOX2; HOXC4; SUV39H2; ZNF268; CUX2; ETV5; ZNF202; CRYM; PEG3; ZNF8; NR1H2; STAT4; KDM5C; CDX1; CD3D; NKX2-1; GFI1B; RFX5; SIM1; EMX2; NR1I2; SUPT4H1; ZNF787; ELF4; ESRRG; FOXJ2; EVX1; ZNF264; OVOL2; MED17; MAFB; NHLH2; RORA; PIAS4; TEAD3; TWIST1; HOXD11; IRF8; RFX2; TRIM24; MAFF; EGR1; MDM2; BRF2; ZNF394; LZTS1; ZNF304; MAK; NFE2; ZBTB7A; BCL3; LHX6; PRRX1; SOX12; PAX6; PHOX2A; OVOL1; FOXG1; L3MBTL1; ZNF135; TRIM25; GRHL2; ZNF205; GFI1; THAP10; PCGF3; CSDC2; HLF; HOXB2; ZNF606; PFDN5; HOXD1; SMAD6; PKNOX2; PHF1; ZSCAN32; BRD4; CEBPG; KDM5D; EHMT2; HIRA; RYBP; SUPT3H; ATF4; ZBED2; RBPJ; TCEA1; ID1; TERF2; PNRC1; HAND1; HHEX; ZNF611; AR; IRF1; PHIP; ZBTB43; CREM; BRD2; RAD21; ZNF552; ID3; PHOX2B; RXRA; ZNF467; NPAS2; PIAS1; ZNF83; SSX1; ZNF529; ZIC1; NLK; ARNTL; ZNF426; ATF3; INSM1; NR1H3; ZSCAN31; REL; CITED2; SIX2; SP140L; NR4A2; ZNF444; ZNF432; TRPS1; DBP; SOX17; ISL1; CALR; PITX1; PROX1; ZNF165; TOB1; HDAC4; ARID1A; NFE2L3; HEY2; HOXB6; POU2AF1; ZNF532; JUND; NR0B1; TGIF1; ZBTB20; SALL1; FOSB; ZFP36L2; CEBPD; KLF4; SOX10; OSR2; CREB3L2; MECOM; FOXA1; VDR; ZFPM2; MYRF; WT1; BTG1; DLX2; FOXF1; BHLHE41; EYA2; NFKB2; HES1
Down-regulation 151 RHOA; LOXL2; ATF6; PSIP1; FHL2; EZH2; BASP1; ECD; CCNA2; MYCBP; XBP1; TFDP1; SUV39H1; SMARCC1; HDAC2; HOXA10; MYBL2; MAGED1; ATF1; BRCA1; EDF1; NELFB; HNRNPD; BRD3; BCLAF1; RB1; BHLHE40; SFPQ; RBBP4; NCOA1; SMAD3; TLE1; CBFB; NRIP1; NR2F2; NPAT; PHF2; FLNA; SMAD2; PURA; RNF4; BMI1; TRIM32; NAB1; NCOA4; CDK2; TLE4; YWHAB; RCOR1; CHD7; ZNF146; SUB1; SNW1; CENPF; PBRM1; VEZF1; WHSC1; CRY1; REST; UBE2I; NEDD8; NCOR2; TCF12; URI1; RBM14; BRD7; HDAC6; ITGB3BP; HMG20A; TGFB1I1; MEF2A; RARA; SMARCA5; HOXC6; TCERG1; ZBTB38; TSC22D2; TBL1XR1; ZMYND11; DNAJC1; SF1; KLF6; ENO1; TRIM16; PSPC1; UBP1; NFKB1; JARID2; DMTF1; SETD3; ZBTB11; MMS19; MED4; TAF9; PREB; PTRF; EED; SMAD7; MTDH; DDX5; HSF2; GTF2IRD1; NRBF2; SPEN; STAT3; MED24; SETD2; ELF1; AATF; ING2; MYBL1; BAZ1A; CDYL; CUX1; RUNX1; HMGB1; ZNF587; ZEB2; ZBTB1; ELK3; TCF25; SIAH2; BRD8; SMARCE1; NFE2L1; RBBP8; TRIP6; SMARCA2; HDAC1; MED1; ZBTB18; MLXIP; ZEB1; IKBKAP; CTNNB1; CEBPZ; LEF1; SMAD1; TXNIP; NUP62; FOXC1; KLF2; TBL1X; IRX5; NR3C1; IFI16; TRIM29; TOX3; TCFL5; ADRB2; PPARG