Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08484 Alvocidib GSE70138 HA1E Human 24h 10uM EID0012
Types Number Response transcription factors
Up-regulation 507 SPDEF; MEF2C; EGR1; SOX2; IKZF1; THRB; ZNF695; LIN28A; ZNF682; HESX1; ZNF816; RSF1; HIF3A; SOX3; ZNF208; ZNF362; ETV1; PDX1; ZNF391; ZNF471; ZNF154; ASCL3; VENTX; PROP1; ZNF549; ZNF484; POU6F2; ATF7; NKX3-2; ZNF257; PRDM9; GBX1; FEZF2; HOXD13; MAML3; FOXD3; ZNF442; ZKSCAN8; RBPJL; RORB; UTF1; LZTR1; FOXE3; SCRT1; ZNF157; ZNF407; GCM2; HOXC5; RFX3; ZIC3; ZNF221; SCAI; POU2F3; ZNF234; SOX11; ZKSCAN4; ZNF814; ZNF235; SOX18; ZNF345; PARP1; ZNF141; MAK; ZNF749; RFX1; POU4F3; ZNF80; CIITA; SOX1; ZNF493; ZNF780B; TEF; L3MBTL1; TBX6; SSX7; PAX4; CARF; ZNF224; ZNF81; ZSCAN2; CHD2; ZFHX2; TBX5; ZNF136; ZNF688; PRDM14; ALX3; ZNF674; ZNF701; ZNF214; SP4; NACA2; ZNF675; DCC; ZNF492; POU1F1; ZBTB3; ALX4; IKZF2; ONECUT1; PRDM16; KLF8; ZIC4; HOXD12; SOX5; VSX1; ZNF710; ZNF44; PAX7; ZNF254; ZNF343; TSHZ2; NEUROG2; ZNF132; MSX2; HSF4; DOT1L; ZIM2; ZFP69B; MYCBP; ZNF41; MYEF2; NEUROD4; ZNF550; INSR; FOXH1; NEUROD6; HES2; ZNF264; HEYL; TP73; ZNF225; HIVEP3; NR5A1; TWIST1; ZNF223; ZNF155; TBL1Y; LHX6; ESRRG; SPI1; GRIP1; ZNF350; ZNF440; TBR1; AFF2; WHSC1L1; EMX1; TAF1; PAX1; TBX19; TULP1; GBX2; ZNF174; POU3F4; TBX1; HOXB8; NKX6-1; RUVBL1; ZNF711; SRY; ESRRB; HAND2; THAP9; SOX14; DMRT1; ZNF613; FOXL1; GSC2; HAND1; MEOX2; PRDM5; ETV3; AIRE; POU5F1B; ZNF75D; LDB1; MYF5; FHL5; TLX3; HDAC9; PGR; EHMT2; ZNF334; TFDP3; FOS; SALL2; NEUROD2; ZNF286A; ZNF117; ZNF112; IRF6; ZNF287; OVOL2; TAF4B; ESR2; GCM1; BRDT; ZFP2; ZNF623; ZNF835; ZNF124; ZNF460; TBX4; VHL; MED25; SUPT3H; SIX3; FOXB1; TULP2; NFIX; ZBTB7C; CDX4; ZBED2; CBFA2T3; NR0B2; PBX1; ESR1; HOXA3; SIX6; ZNF606; LBX1; NANOG; IKZF3; ZNF273; HOXA2; ZNF253; CUX2; ZFY; FOXJ1; ZNF669; MEIS2; MLLT1; ASCL2; ARNT2; SOX17; ZNF507; TCEA2; CALCOCO1; NHLH2; TONSL; ASH1L; HOXB1; NR1H4; ZNF480; ZNF667; TLX2; NPAS1; AEBP1; ZNF589; ZNF135; TAF6L; MDM4; HNF4G; HMX1; EMX2; ZNF611; ATOH1; MECP2; ACTL6B; SOX21; EBF2; ZNF180; HNF4A; MZF1; GTF2A1; HOXD3; PAX3; PPARA; GRHL2; DLX6; E2F4; SRCAP; ZNF778; REL; NR5A2; ZNF528; ZNF304; ZFPM2; ZNF91; ZNF544; ZNF415; VGLL1; PRDM1; HDAC6; ZNF211; AR; POU3F2; CBX8; ZNF215; MED12; RORC; NR4A1; HIPK2; EGR3; ZNF331; ZNF771; BCL11A; ZNF10; TTF2; NR4A3; MAPK8IP1; TFAP2A; EGR4; NHLH1; BRWD1; TBX10; CREG1; THRA; ZNF358; SHOX; TFDP2; ZNF529; EN2; SHOX2; HDAC5; ZNF671; TLX1; RING1; ZNF423; OSR2; NR2E1; ZNF426; LHX3; STAT2; MYCL; ZNF665; CBL; TDRD3; TSC22D3; SKIL; NFATC4; HNF1A; IRF1; NR4A2; ZNF551; SKI; HEY2; MDM2; ZNF268; CRYM; TUB; EGR2; FOXF1; SIX5; ZKSCAN7; ATF6B; ZNF467; ZNF85; ZFP37; KLF15; NR1H3; PBX2; ARID3A; PRDM2; POU4F2; PLAGL1; CREBL2; SSX3; DLX5; NFIC; CD3D; ERCC2; EVX1; CEBPA; NFE2L3; SOHLH2; NFAT5; ING4; ZNF562; ERBB4; SUV39H2; MYT1; LZTS1; ZNF8; SUPT7L; GATA1; ST18; ARID5A; ZBTB44; BARX1; ZNF536; ISL1; BNC1; ZNF93; ZNF770; ZNF573; HLX; CIR1; HIC2; TRIB3; ZSCAN9; ZNF205; MED14; CDIP1; HOXD1; TOX; NEUROD1; TCEB2; USP16; CALR; ZNF222; WDR77; CBX7; PHOX2A; PHOX2B; RBFOX2; TFEC; CSDE1; LITAF; TRPS1; CDX1; CEBPE; ZNF721; MBD4; GLI3; NR1I2; EN1; BHLHE41; OVOL1; FOSB; CNOT3; ATN1; MAFF; INSM1; MNDA; MECOM; MNX1; PEG3; CREB5; MAF; ZNF195; FLI1; ZFHX4; FOXG1; WT1; ETV5; SAP18; ZNF83; TCEA1; PHF1; ZNF654; RUVBL2; E2F5; MSX1; ZNF107; ZNF184; ZNF43; CERS6; BNC2; ZSCAN31; ZNF552; SMAD5; PITX1; PRRX1; WNT4; THAP10; HMBOX1; TRIM24; NKX2-2; ZNF232; GTF3A; TDP2; NR2F1; ZNF430; TCF7; NAB2; ZNF532; RBBP8; TFAP2C; HEY1; KLF7; HMGA1; ZSCAN18; RORA; HLF; TXNIP; TCF21; IRF8; MITF; MXI1; FOXF2; ID3; JUP; PAX6; AHR; NPAS2; MYCN; DLX2; SATB2; EYA2; SMAD6; NR0B1; LEF1; ZNF329; SNAI2; ZNF160; CEBPZ; NR1D2; BACH2; MAFB; ATF3; TBX2; E2F2; GATA2; MEIS1; CEBPD
Down-regulation 192 CCNA2; HOXA5; USP22; FHL2; FOXO3; PUF60; HDAC2; BASP1; XBP1; NFIL3; HOXA10; ECD; BHLHE40; BRCA1; SMAD3; FOXJ3; TBP; SUV39H1; ATF1; RBM14; VEZF1; EZH2; ZNF146; CDK7; HNRNPD; SNW1; ARID4B; MYBL2; CCDC59; UBE2I; PAX8; HOXC6; BIRC2; HIF1A; CRK; BAZ1B; BRD3; SFPQ; PPRC1; TAF5; MED6; RARA; NRIP1; ID2; BCLAF1; SCAND1; CRY1; RAN; RBBP4; CENPF; ADNP2; MYBL1; ADNP; MBD2; TRIM32; HMGB2; NPAT; YWHAB; ASXL1; MED1; THAP11; PHF20; ZBTB24; RAD21; AFF1; DDX54; ARID5B; ILF2; SSRP1; TBL1XR1; RNF4; SP3; SAFB; PRDM4; KAT7; MED13; ING2; TLE1; ZBTB1; AATF; FOXK2; ZBTB11; SMARCA5; SF1; RNF138; WHSC1; REST; KLF10; HOXB7; NFKB1; PATZ1; TGIF1; ZNF131; DEK; MAX; BLM; GATAD2A; NPM1; DNAJC2; NFKBIA; NKX3-1; CTCF; HMG20A; NR2F6; HOXA11; FLNA; APEX1; CCNC; RELA; COPS5; SMAD4; TBPL1; ZNF410; SMAD1; BTG1; SMAD7; RNF111; TRIM16; NUP62; TCF20; MGA; SUZ12; IRF7; NCOA6; CNOT1; CDYL; ARNTL; CIZ1; RNF6; CBX5; URI1; NCOR2; IRF2; TULP4; CHD8; CBX3; CENPB; RCOR1; ZMYM2; EED; CTBP1; KMT2A; BAZ1A; ETS1; RBM39; TOB1; ZNF217; MYC; SIAH2; SMARCE1; SUB1; TP53; FOSL1; BATF; PURA; SMARCA2; NRBF2; TRRAP; STAT3; CEBPG; TSC22D2; CCNE1; JARID2; CITED1; BMI1; JUND; ANKRD1; KLF9; CBFB; BRD8; TBL1X; HMGB1; HOXB6; ELF1; CTR9; ELK3; RUNX1; REPIN1; SAP30; FOXD1; ZBTB18; TAF10; CTBP2; FOXO1; ZFP36L1; MNAT1; HOXC10; KLF6; SOX9; NR3C1; TCFL5; ADRB2