Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08233 Mitoxantrone GSE70138 HA1E Human 24h 3.33uM EID0010
Types Number Response transcription factors
Up-regulation 518 SSBP2; PRDM14; ZNF117; SOX5; NR5A2; ZNF551; ZNF264; ZNF667; L3MBTL1; ZNF154; SOX21; ZNF224; TWIST1; ZNF688; MYCBP; MAML3; KAT2B; ZNF467; BCL11A; ZNF391; ZNF695; ZNF606; GBX1; NEUROD2; THRB; NFATC4; ALX4; TCEA1; HOXB1; MAK; HOXC5; RFX3; TULP1; CHD2; FOXD3; SOX18; RFX1; ZNF440; HOXC8; SSX3; ZNF136; PDX1; RBPJL; RFX2; FOXO4; CARF; ZFHX2; TBX6; ZNF816; HESX1; ATOH1; ZNF362; PSMD9; NFIX; SRY; SCAI; NKX3-2; HIF3A; HOXD3; HES2; ASCL3; RNF2; HSF4; LHX3; ZNF682; ESR2; ZNF211; FEZF2; POU6F2; HEYL; TSHZ2; ZNF701; PROP1; ZNF75D; HNF4G; SSX7; TP73; ING4; ZNF257; TFDP2; CIITA; DOT1L; MXD4; ZNF254; PAX1; ZNF345; THRA; DLX6; ZNF273; EMX1; SCRT1; ZNF711; DLX5; PAX7; HAND1; VENTX; SPI1; TLX3; HOXB8; NEUROG2; HAND2; CREBL2; NEUROD6; POU2F3; OVOL1; NR4A2; HES1; ZKSCAN4; WNT4; FOXE3; NEUROG1; CIR1; PRDM9; GBX2; ZNF639; ZNF208; NEUROD4; EN1; CREM; GRIP1; TAF6L; OVOL2; PAX3; AR; ZNF358; HNF1A; HOXB5; TBX1; NFKBIB; PRDM12; SIX6; MZF1; ZNF749; PRDM16; NOCT; HOXC11; THAP3; TBX10; HOXA3; ZIM2; HOXC4; TAF4B; LHX6; MYF5; ZNF549; POU3F3; ZNF221; PEG3; ZNF471; ZNF771; NACA2; TRPS1; ZNF44; CDX4; ATF6; ATF6B; KMT2D; FOXJ1; FOXH1; NHLH2; SOX1; ZNF76; ZNF43; MNX1; ZNF835; CD3D; ZNF778; FOS; ZBTB7B; IRF6; CBX2; ZNF343; SOX17; ZSCAN2; NR5A1; NPAS1; AIRE; VSX1; MED25; PRDM5; SIX3; ZFP2; ZBTB7C; PBX2; GRHL2; ATF7; HIVEP3; ONECUT1; ZNF669; ZNF492; ESRRB; TAF1C; SHOX; ZNF180; ZNF550; DCC; FOXL1; AFF2; CRX; TFDP3; CEBPD; TLX1; MYNN; PRDM1; NR0B2; ATN1; ZNF135; LMX1B; EPAS1; VGLL1; GSC2; FOXB1; CALR; CERS6; RUVBL1; MLLT1; ZNF710; ZNF304; TEF; LBX1; ETV3; SLC2A4RG; REL; ZNF415; ZNF493; ATF3; HBP1; SP4; NKX2-8; ZNF219; EP300; ZNF623; ZNF124; KLF15; NFKB2; E2F4; NEUROG3; ZNF556; ZNF155; HDAC9; FOSB; HOXD1; MED31; ETV2; SMAD6; CBX8; TBX5; PFDN5; RSF1; ZNF407; EBF2; PKNOX2; PEX2; PRDM2; ZNF8; ZNF586; MEOX2; ZNF334; ZNF80; THAP9; GTF2A1; CDX2; ZNF235; PITX3; CREG1; SIX5; ZNF674; SKIL; LHX5; FHL5; NKX2-5; ZNF223; ALX3; ZNF671; KDM5C; STAT2; MAPK8IP1; ZNF814; MED14; ZNF10; TAF7L; SOHLH2; MXD3; MLLT10; RARG; ACTL6B; ZNF484; NEUROD1; BARX1; TBX19; ZNF215; ZNF157; PRDM10; SPDEF; ZIC3; RAX; DMRT1; ZFY; ZNF132; ZNF528; TLX2; HOXD13; ZNF675; POU4F3; MECOM; ZNF81; TBL1Y; NHLH1; ZNF141; LEF1; MTA2; ZNF442; UTF1; ZNF225; MDM2; ZNF253; SOX3; ARNT; GCM2; NR2E1; RORC; SUPT7L; ONECUT2; DBP; BRDT; ZNF226; LDB1; HDAC5; ZNF611; GATA1; HMX1; POU1F1; HOXD12; SRCAP; ZNF532; DLX4; MBD4; CDX1; ZNF426; LIN28A; SUPT3H; HIPK1; ERBB4; ASCL2; YBX2; ZNF287; CSDE1; POU4F2; WDR77; NFX1; ZNF419; TUB; POU3F2; ESRRG; MDM4; HOXA2; IKZF3; ZNF214; ZNF665; ZNF536; ZNF331; SNAI1; PLAGL1; TBX4; ZNF529; ZNF107; SALL2; SHOX2; TCEA2; RXRG; CRTC1; AEBP1; HIPK2; FOXF1; PHOX2A; TAL1; TAF11; ZNF93; ZNF506; ZNF562; RNF141; ARNT2; PHF1; PAX6; CBX7; ZNF112; ZSCAN31; ZSCAN18; NFATC1; IRF8; FOXP3; IRX5; NR0B1; MEIS2; PRMT2; ZNF770; TOX; SAP18; MYCL; FUBP1; CBFA2T3; SKI; NKX2-2; EHMT2; MXD1; EN2; MNDA; HEY1; RING1; IRF1; NFIC; NR2F1; HLX; EMX2; CHD3; JUP; HMBOX1; CEBPE; HMGN3; PPP1R13L; MXI1; RORA; LYL1; NR3C2; HEY2; SIM2; ZNF184; SMARCB1; FOXA2; ZBTB20; CBX4; HOXB13; TFEC; ATF5; SSBP3; ZFX; TCF21; E2F5; NR1H3; HIC2; NR4A3; ZNF423; NANOG; TCF4; MTA1; ZNF165; KLF1; CNBP; INSM1; RBFOX2; ZFPM2; HLF; SREBF1; INSR; ESR1; PHOX2B; PITX1; ZMYND8; CERS4; GATA6; ETS2; ZNF354A; ZNF32; FOXF2; BCL11B; WWTR1; KLF7; GTF3A; SMARCA1; TCF7; KLF11; NFE2; ENY2; CTNNB1; NFAT5; ZBED2; FOXL2; TLE2; SOX11; HMGA1; GFI1B; TRIB3; PBXIP1; MEF2C; ZNF516; BCL6; PBX1; SSX1; MYCN; WT1; NR4A1; NFE2L3; ISL1; TXNIP; STAT4; DLX2; SOX10; ZNF91; EYA2; MSX1; ZNF83; NR1D2; CUX2; ZNF652; TGFB1; SOX2; BHLHE41; OSR2; ID4; IKZF1; YBX3; FOXG1; ID3; E2F2; MEIS1; ETV1; GATA2; CEBPA
Down-regulation 206 CCNA2; PUF60; FHL2; NFKBIA; CRK; FOXO3; NUP62; XBP1; ECD; FOSL1; MYC; USP22; EED; HOXA10; HNRNPD; ARID5B; ADNP; CENPF; PAX8; VEZF1; TRIM32; TAF5; NFIL3; BHLHE40; PPRC1; NCOA6; SCAND1; SNW1; PRPF6; CDK7; SMAD3; TLE1; AATF; SUZ12; UBE2I; SUV39H1; RNF111; ZNF263; TCERG1; FOXJ3; DNAJC2; CHD8; ZNF146; APEX1; CTCF; RBPJ; NPAT; RBM14; TBP; MED13; ZNF410; CHD1; ZBTB24; SMARCA5; MYBL2; TAF9; CTR9; BRPF1; MED6; SOX4; ASXL1; NRIP1; HOXA5; NKX3-1; PHF20; TRIM27; FOSL2; RNF138; KAT7; MED1; TAF4; RBM39; DDX54; PLAGL2; SFPQ; BRD3; HMGB2; ANKRD1; DEK; CNOT1; ZFP64; FOXK2; SOX9; MGA; BCLAF1; CRY1; ZNF148; PATZ1; SETD2; MNT; ZMYM2; ZNF217; RLF; YWHAB; RELA; SAFB; CARM1; ZBTB38; ZBTB18; SMAD7; MLX; ARNTL; BRD8; MED17; TSC22D2; DPF2; KMT2A; CIZ1; ZBTB1; GTF2IRD1; AIP; BAZ1A; TAF10; JUND; PREB; ZMIZ1; ZNF266; KAT5; TRIM29; ZNF672; KAT6A; ATF1; MAX; MBD2; MEN1; KLF6; ELF5; STAT5B; ING2; TRIM16; KAT8; RAN; SMAD2; ZBTB11; BAZ1B; HOXA11; BASP1; ZNF281; SIAH2; SALL1; REST; BLM; EZH2; CBX3; ILF2; TMF1; RUNX1; SSRP1; PDLIM1; CENPB; TCF12; NCOR2; CEBPZ; AFF1; BRCA1; NR2F2; RYBP; CEBPB; TOX3; CREB3L1; TRIM28; ARID4B; IKBKAP; CDC5L; PTRF; GATAD2A; NR2F6; BMI1; HMGB3; FOXC1; MAFB; KDM5D; TBL1X; ZNF12; BCOR; ZFP36L2; STAT3; MTF2; TAF1D; PURA; ZNF131; SMAD1; FLNA; RARA; IRF7; ATF7IP; SERTAD2; RBBP4; POU2AF1; REPIN1; TBL1XR1; EGR3; CTBP2; EGR2; BIRC2; CREB3L2; ID2; FOXD1; SPEN; ASCL1; MYBL1; ABL1; BTG1; SATB2; TBX3; NR3C1