Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08177 Azd-7762 GSE70138 HA1E Human 24h 1.11uM EID0010
Types Number Response transcription factors
Up-regulation 615 NFKB2; KDM5B; FOXO4; ZNF701; ZFY; NFKBIB; CHD2; ZNF695; PRDM5; TBX1; ZNF75D; ARID3A; MXD4; STAT2; TCFL5; NEUROD1; STAT5B; ZKSCAN8; NKX3-2; ZNF141; NR2C2; SSX1; TBR1; SP4; ZNF257; SSX7; WHSC1L1; BARX1; POU2F3; HAND2; SHOX; SRY; ZNF391; POU4F2; HOXC13; BRWD1; HR; ZNF440; ZNF749; BRDT; ZNF492; ZNF286A; NFIX; ZBTB7C; TAF4B; IKZF2; RARG; DLX4; IRF6; NFATC1; EGR4; RFX3; ONECUT1; MAML3; NR0B2; GCM1; ZNF80; HDAC5; ZNF460; EMX1; EGR2; ZNF471; ZNF287; ZNF214; ZNF407; PAX4; ZNF613; MAPK8IP1; EN1; TULP1; IKZF3; POU6F2; ZNF682; SUV39H2; ZNF254; ZNF780B; HNF4G; SOX5; BNC1; FOXE1; TCEA2; NR6A1; ZNF117; EYA3; ZNF674; PRDM9; OVOL1; TXNIP; ZNF107; ZNF155; TLX3; IRF9; ZNF81; NEUROD4; ZNF157; GCM2; NHLH2; ASCL2; BARX2; CREM; DOT1L; CBFA2T3; ATF3; WNT4; ESRRG; DLX5; ZNF225; FOXL2; ASH1L; TULP2; NKX2-5; ZNF343; TP73; ZNF154; TFAP2B; SMARCA5; ZNF480; CDIP1; DMRT1; ZIC3; FOXI1; ZNF442; RUNX3; ZNF816; POU3F1; PAX9; SOX30; SCRT1; VHL; MSL3; FOXD2; CIITA; ZNF274; PRDM13; ZNF79; ZNF221; KAT5; THRB; ZNF549; ZNF506; ZBTB6; POU4F1; POU1F1; ZIM2; ZNF132; NEUROG3; ETS2; ZNF235; ZNF415; L3MBTL1; PEG3; SOX14; ZBTB3; POU3F3; ZNF493; ZNF814; TEF; KDM5D; GSC2; HMG20B; NR3C2; ZNF507; MTF1; IFNB1; THRA; ZNF136; ZNF234; ZNF345; ZNF571; MDM4; NFKBIA; TRIM25; AFF4; TAF7L; MLLT1; ZNF550; HOXA2; SOX18; KLF3; MAK; POU6F1; HES2; ASCL3; ZNF835; VGLL1; DLX6; NFX1; ING4; MXD1; ZXDB; IRF8; PPARA; PLAGL1; SOHLH2; KLF10; KMT2D; REL; GRHL2; SOX21; MSX2; NAB2; NKX2-2; FOXE3; EGR3; PBXIP1; THAP9; RFX2; HIC1; MTA2; CEBPD; PML; FEZF2; KLF8; LHX6; ZNF778; ZBTB44; ZNF41; GRIP1; OLIG2; NR5A1; DNMT3B; ZNF557; EHMT1; FOXB1; TOX4; SP140; HDAC11; SIX3; ZNF711; ZNF10; POU3F4; FOXD3; PAX5; ZNF208; RORC; PKNOX1; PIR; HIC2; ZBTB39; TBX4; MDM2; TLX1; YBX2; TADA2A; RSF1; ATF7; PLAG1; NSD1; ZNF236; LZTS1; HOXC11; TBX5; ZIC4; SHOX2; MBD1; ZNF639; TLE2; HOXB8; ZNF764; PRDM14; GFI1B; ZNF671; TOPORS; CBX2; ATOH1; PDX1; E2F8; ZNF8; PROX1; NR1I3; POU4F3; PPARD; CARF; ESR2; SP1; ETV3; ZNF223; ZNF556; EGR1; HAND1; KMT5A; HESX1; TRIM22; NEUROG2; ALX4; SMAD2; SSX3; SOX10; CCNT1; ZNF273; NR1I2; IRF1; EP400; ZKSCAN4; BACH2; NEUROD2; JAK2; TBX21; SAP18; TAF6L; SOX3; NR5A2; CRX; CASZ1; GATA1; MYNN; LHX3; MYEF2; ZNF134; ZNF710; LMO1; PLAGL2; ZNF675; HIPK2; TRIM27; CAMTA1; E4F1; ZNF205; ZNF529; PHF8; ZNF337; DCC; RBPJ; EN2; AFF2; NCOA1; TFEC; ZNF227; SOX1; ZFP2; FOXA2; MED12; ZKSCAN7; ASH2L; FOXN2; ETV7; CDX1; NKX6-1; ZNF33B; NFIL3; CBX8; FOXN1; MXD3; NKX2-1; NR0B1; MLLT10; ARNT; GABPB1; ZFP69B; TFCP2; GABPA; MED31; NEUROG1; NACA2; ZSCAN16; IL16; YY1; PAX7; HINFP; SMAD9; ZHX3; ZNF688; E2F1; NHLH1; POU2F2; TAF4; NKX2-8; TBL1Y; ZNF215; STAT4; NAB1; NFYA; ONECUT2; RBL2; ZNF536; INSM1; ZNF282; HOXA1; CDX2; CREB5; ID4; PITX1; SIM1; PRDM8; PAX3; HOXB13; AFF3; AIP; BCL11A; IRF7; MBD4; ZNF324; VAX2; EBF2; ZNF253; KAT6A; PKNOX2; HOXC5; SNAI1; PAX6; TFDP3; LHX2; ZBTB7B; GTF2A1; LMX1B; TCF21; CAMTA2; PRDM10; TLX2; ZNF226; ZNF180; MEOX2; HEY1; MEN1; ZNF408; PRMT2; PRDM1; SNIP1; TP63; ZNF93; ZNF85; ZNF219; ELK4; ZNF334; RFX1; PAX2; ZNF165; TAF1; EZH2; MAFK; MSX1; ZBED2; HIF3A; ID2; GTF2I; FOXJ2; LEF1; RBBP7; UBE2L3; ZNF74; ASCL1; ZFP30; GBX1; YAF2; SMARCA1; UBTF; ZNF528; SAFB; ZNF195; HOXD13; CCNE1; DDX17; ING1; TGIF1; CBL; RFX7; ZNF329; CBX6; CTNNB1; ACTL6B; NR1H4; HTATIP2; ZNF813; RNF141; SMARCD2; ZNF552; ELF2; ZNF770; KLF6; BCL6; SMARCD3; HHEX; TAF1D; PRDM2; TEAD1; BLZF1; BATF; NPAS1; FEV; ANKRD1; TRIB3; LYL1; HMGA2; ZNF304; LPIN2; PNRC1; TRAF6; SPDEF; SMAD5; GLI2; BACH1; MYT1L; ZNF672; CBX7; SATB2; CBX4; FOXA1; BRF2; JUN; ZNF787; FOXG1; HOXD1; ZBTB32; BANP; OSR2; FLI1; HLX; TFEB; DLX2; TEAD3; WWP1; NR4A3; PGR; ZFPM2; MSC; TSC22D4; POU3F2; ARID4A; RBBP4; KLF11; MLXIP; NFE2; SKI; ARRB1; KLF1; SATB1; IRF5; OVOL2; JUP; IRX4; TWIST1; CRYM; STAT3; SERTAD2; PMF1; TSC22D3; RBPMS; CITED1; ZNF350; GFI1; TAF9B; PIAS3; ING2; MAFF; CUX1; NFYC; BCOR; NR1H3; NFE2L3; SOX13; GATA6; NFKB1; FOXN3; HEY2; DDIT3; HMBOX1; TOX3; CEBPA; LITAF; TOX; RORA; FOXF2; ZNF239; TCF7; ELF3; PURA; NCOA4; FUBP1; SALL2; EYA2; TRIM33; IRX5; TLE4; ELF5; CERS4; HMGB2; PHOX2B; ZNF43; FOXD1; ETV1; FOXO1; NFAT5; KLF5; TFAP2C; CREBZF; MNDA; BRCA1; JUNB; PAWR; E2F5; HDAC9; ZIC1; POU2AF1; STAT1; TCF4; CUX2; NR4A1; ZNF83; RFX5; KLF4; SOX11; NR1H2; ZBTB16; FOXF1; BTG1; MEF2C; IKZF1; NR2F1; RELB; AEBP1; ADRB2; PPARG; SNAI2; E2F2; GATA2
Down-regulation 194 CRK; TLE1; CCNH; GMNN; LOXL2; CCNC; CNBP; CBX3; PRKDC; ATF2; ARID5B; WWC1; MXI1; SMARCA4; HOXA10; NUP62; TCEA1; ARNTL2; ZNF593; ZMIZ1; MAZ; ZBTB18; ZNF148; ATF4; TBL1XR1; YWHAB; SF1; TCF3; ORC2; ARID4B; ZNF32; HNRNPD; PBRM1; ZNF189; CENPF; ZNF430; MTA1; BRD3; CCNA2; NRIP1; COPS2; VEZF1; FLNA; TEAD4; ITGB3BP; C1QBP; EDF1; NR2C1; HMGA1; NR2F2; RFC1; ZFP36L1; USP22; BRD4; PTRF; COPS5; HOXA5; TAF11; TRIM32; GTF2IRD1; ERCC3; SMAD6; ZNF217; POLR3F; NFE2L1; GTF3A; ENO1; HSF1; ATF5; ZEB1; REST; MAGED1; CTCF; SP3; PBX3; ZNF23; PCGF1; GATAD2A; CIZ1; ZBTB38; ZEB2; PMS1; DNAJC2; HIF1A; CARM1; RNF4; HDGF; BRD8; TFDP1; ZNF281; ZZZ3; GCFC2; ZNF580; ENY2; ARID1A; UBE2B; TULP3; THAP4; RBM39; BIRC2; BCLAF1; SIX1; HMGB1; UBP1; SMARCC1; PSMC3IP; PATZ1; JUND; WHSC1; KLF7; TRIM28; MED6; BHLHE40; UBE2I; TRAK1; CSDE1; NR2F6; BTAF1; AFF1; ZNF423; YEATS2; PA2G4; REPIN1; BTF3; TTF1; NPM1; NPAS2; CEBPB; HMGXB4; SUPT5H; CNOT1; NELFB; ZNF12; TRIP6; BMI1; CHD1; PHF1; ESR1; XRCC6; RUVBL2; MTF2; PHF20; ATN1; TAF10; TFAM; TOB1; HIPK1; ELK3; TGIF2; CHD7; SP100; PEX2; ETV5; ZHX2; MED1; TBX3; CALR; RAD21; SRCAP; SFPQ; MTDH; WWTR1; DNAJC1; ZMYND8; JARID2; MNAT1; BHLHE41; PQBP1; NFIB; HLTF; RCOR3; MED15; STAT6; CARHSP1; CBFB; CHD9; MEIS2; SMAD1; CITED2; NR1D2; SPEN; TGFB1; AHR; HMGN3; PBX1; IFI16; ID3; HOXC6; MYRF; ID1; MEIS1; YBX3; THAP11; CREB1