Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08158 Azd-5438 GSE70138 HA1E Human 24h 10uM EID0010
Types Number Response transcription factors
Up-regulation 705 EGR1; PRDM14; CHD2; SRY; ZNF154; FEZF2; ZNF75D; ZNF264; ZNF695; ZNF224; ZNF606; FOXO4; SCAI; ZNF682; ZNF257; ZNF701; ZNF391; ZNF688; TP73; POU2F3; MAML3; TBR1; TWIST1; POU6F2; ZNF345; EMX1; SSX7; CARF; E2F4; CEBPD; ZNF235; ZNF551; ZNF136; SOX18; ZNF117; NR1H4; SCRT1; ZIC3; PRDM9; ASCL3; ZNF549; SPI1; RFX1; RFX3; HNF4G; ZNF440; ZNF221; NEUROD4; NEUROD2; PRDM5; GBX1; ZKSCAN8; ZNF749; ZNF667; ASH1L; SOX5; THRB; NFIX; NEUROD6; SHOX; NEUROG2; PDX1; SOX21; ZNF225; VENTX; LHX3; ATOH1; FOXD3; NHLH2; TFAP2A; ZKSCAN4; ZNF816; ZNF814; THRA; SIX6; L3MBTL1; NR5A2; ZNF273; RBPJL; ZNF573; MEOX2; ZNF471; ZNF362; NR6A1; ZNF223; HOXC5; CIITA; ZNF623; ZNF174; DOT1L; ZNF343; ZNF208; GRIP1; BARX1; ZNF423; ETV3; ZNF135; SP4; SOX1; ZBTB3; MDM4; FOXH1; ZNF141; NR5A1; ZNF415; ZFPM2; AR; IRF6; ZNF778; TULP2; BRDT; WHSC1L1; TBX1; HOXB8; ZNF81; CBX7; BNC1; ZNF180; ZNF214; ZNF304; FOXE3; ALX4; VHL; NKX3-2; HESX1; ZNF287; HOXD13; OVOL2; NFATC4; TULP1; TBX5; ZNF407; TCEA2; PRDM2; ZNF157; CRX; CAMTA2; NEUROD1; SOX14; ZNF80; ZNF835; ZNF665; ZNF674; ETV2; HSF4; DCC; MAPK8IP1; ZNF500; HAND2; HOXA3; ATF7; TEF; POU1F1; TLX2; ZNF550; IKZF2; PAX4; ZFY; ZFP2; HES2; TLX3; ZNF669; MAK; GCM2; NFKB2; ZNF544; KLF8; BCL11A; ZNF780B; HEYL; SALL2; ZNF467; ZNF132; POU3F3; SOX17; MLLT1; ZNF492; ONECUT1; GSC2; TBX6; NEUROG3; HIPK2; PAX7; ZIM2; HOXB1; ZNF286A; PROP1; ZFP69B; ZBTB44; ZIC4; ZNF536; TAF1C; EN1; ZFHX2; ZNF442; POU4F2; LIN28A; ZNF155; ARID3A; ZNF484; ZNF219; CD3D; ACTL6B; INSR; HOXD3; SSBP3; PAX1; FOXB1; ZNF41; ZKSCAN3; SOHLH2; HDAC9; JAK2; ZNF711; HAND1; MED12; HOXD12; ZNF234; POU4F3; MSX2; RORB; HLX; ALX3; ZNF74; ZNF93; CCNT1; MYT1; ZNF232; SSX3; EP300; ZNF334; ESRRB; THAP9; LDB1; ZNF34; ZXDB; TCEA1; HMX1; ZNF254; ZFP37; ZNF771; NFKBIB; PPARA; AIRE; CBX4; ESRRG; GCM1; SOX30; TAF4B; MYCL; NPAS1; ASCL2; HSF1; ZNF675; LBX1; TONSL; MED31; NHLH1; BAZ2A; POU6F1; NR2E1; NACA2; ZNF613; HDAC5; MYEF2; BRWD1; NOCT; PBX2; ZNF215; PRDM16; RSF1; FHL5; NKX6-1; THAP10; IKZF3; ZNF480; NKX2-5; KDM4C; CBFA2T3; RARG; NR4A2; ZNF253; ZXDC; ZNF43; ZBTB6; ZNF91; HIF3A; MDM2; SHOX2; CALCOCO1; GBX2; TAF6L; ING4; TBX4; PEG3; ZBED2; ZSCAN2; ZNF671; CERS4; E4F1; ZNF331; CDX4; HNF1A; FOXL1; MYF5; DLX5; LZTR1; ZNF142; SIX3; ZNF507; RORC; CEBPE; KLF13; HNF4A; SIX5; ZNF506; EVX1; HHEX; CDX1; ZNF205; ZBTB7C; ZNF460; MZF1; TLX1; NR0B2; ZNF557; KDM5C; HOXD1; MNX1; HIVEP3; CDIP1; POU3F4; ZNF556; PRDM10; SOX3; PRDM12; ZNF112; THAP7; SUPT7L; ERBB4; EPAS1; ZNF493; DMRT1; ZNF124; TRIB3; MYNN; OVOL1; CNOT3; REL; NEUROG1; ZNF44; DLX6; ZNF85; PAX3; OLIG2; HIRA; LHX6; TBL1Y; UTF1; ZNF8; AFF3; ZNF696; NR0B1; ATF6B; CBX2; KLF15; ZNF350; ZNF770; FOXI1; HDAC4; ZNF107; EZH1; ZBTB48; VGLL1; ZNF358; SUV39H2; POU2AF1; ARNT2; RNF2; TAF1; FOXN1; CREB5; NFX1; ZNF10; SPDEF; ARHGAP35; HDAC11; ONECUT2; MNDA; TFAP2B; BNC2; HIC2; KMT2D; HIC1; PBXIP1; GRHL2; CIC; CBX8; TCF4; IRF1; NR2C2; GFI1; FOXJ1; PAX6; ELK4; EHMT2; TFDP3; ZSCAN9; POU3F2; SKIL; APBB1; NRL; ZNF195; ZNF532; NFIC; ZNF611; HOXA2; ESR2; VSX1; EN2; ST18; NANOG; ZNF35; SIN3B; ATN1; ZNF324B; FOXA1; RAX; ZNF710; CREG1; TUB; FOXD2; ARID3B; CSDC2; PNRC1; ZKSCAN7; ZNF764; PIAS4; CALR; GTF2A1; AEBP1; SUPT3H; ZSCAN32; NFE2L2; AFF2; TFEC; PITX3; SCAND1; GLI2; FOXF2; IKZF4; MECP2; DLX4; SOX13; AES; FOSB; CUX2; JUP; MEF2D; FOXC2; PRDM1; PHOX2A; EBF2; RXRG; CERS6; PKNOX2; ZBTB7B; MYRF; MED25; LMX1B; ZFHX3; SP1; ARID5A; ZNF354A; WNT4; CREBL2; NKX2-2; FOXP3; TBX10; TAF5L; BARX2; ZNF79; SALL1; SOX11; CRYM; LYL1; SLC2A4RG; ZSCAN18; ZNF787; SNAI1; CIR1; PAXBP1; GCFC2; TSHZ2; HMBOX1; CRTC1; MBD4; ZNF562; STAT2; MEIS2; KLF3; SSX1; MAP3K10; SOX15; LITAF; TAF7L; PFDN5; HOXB5; TCF21; ETV7; TGIF2; FOXG1; ZNF654; HBP1; EYA3; TBX19; E2F1; PHOX2B; MTA2; ZNF239; RFX7; ZBTB20; KAT2B; TFEB; ZNF133; HOXC8; PITX1; ARL2BP; PRRX1; SP140; ZNF394; NFAT5; ZNF580; ZBTB39; ZNF3; RORA; SRCAP; SNAPC4; TFDP2; ZNF324; ZBTB17; CBFA2T2; ATF3; TERF1; SETDB1; ESR1; SMARCA4; CDX2; POU2F1; ZNF211; BRD4; PBX1; SSBP2; ISL1; TAF1A; FOXJ2; ZNF692; HINFP; SIM1; DBP; MAFK; ZFP36L2; RBL2; CNOT2; TCF7L2; ZNF646; ZNF175; ZNF426; ZNF528; ZNF768; NR3C2; POU5F1B; GATA1; RING1; SMARCD1; ZNF430; MED14; TEAD3; NLK; MYT1L; PHF1; HLF; NPAS2; AFF4; TAL1; TOPORS; EYA1; ZSCAN31; LHX2; ZNF444; IRX4; HOXB13; C1QBP; CBL; YBX2; FOXF1; ZNF529; SCMH1; HOXC4; IRF8; WT1; ZNF652; HOXB2; LMO1; MKL2; NR4A1; PAX5; VPS72; KLF1; TBX21; PROX1; NR1I3; BHLHE41; BRD2; CREM; FOS; HOXD11; EMX2; FEV; HEY2; OSR2; DLX2; HEY1; KLF7; FOXL2; ZNF589; E2F5; MXD1; NR1I2; ZHX2; ZNF12; KAT6B; NR4A3; SMARCB1; ZNF571; TULP3; NR1H2; FOXN3; CAMTA1; ARID1A; INSM1; ZNF268; PIAS1; BACH2; HMGA1; MED15; MAFB; ZNF329; BCL11B; BAZ2B; PLAGL1; TCF7L1; TXNIP; STAT4; FLI1; HOXD10; NFE2L3; TERF2; MYCN; MTF2; JUNB; ZNF22; POU4F1; TGFB1; NR1H3; BCL6; FOXA2; NR2C1; TLE2; ZNF184; NCOA3; RFX5; EGR2; MECOM; SPIB; ETS2; CTNNB1; TRPS1; RBFOX2; SOX2; SNAI2; NFE2; SMARCA1; TRIM24; MEF2C; YBX3; ZNF721; SMAD1; ERG; KLF2; ID1; MSX1; ID4; SATB2; CITED2; TBX3; IKZF1; LEF1; MEIS1; ID3; CEBPA; TRIM22; E2F2; GATA2; THAP11
Down-regulation 188 FHL2; CCNA2; NUP62; PUF60; CRK; SUV39H1; CENPF; ECD; TLE1; NFKBIA; HNRNPD; TCERG1; XBP1; TP53; EED; ENO1; SNW1; HDAC2; FOSL1; PAX8; SMAD3; TBP; LOXL2; ATF6; TRIM32; PDLIM1; VEZF1; BHLHE40; EDF1; UBE2I; ZNF146; RBM14; USP22; TAF9; DNAJC2; HOXA10; ATF1; BRD8; RNF4; SMARCE1; NPM1; MYC; NPAT; SMARCA5; ZMYM2; CDK7; CCNC; NELFB; DDX5; NFIL3; MED27; TRIM27; REST; CTR9; NCOA4; HOXA5; ING2; FOXO3; ZBTB1; MED1; CDYL; CBX3; GTF2A2; WHSC1; PTTG1; NRIP1; NFE2L1; NFKB1; MED6; ELF5; RB1; BRD3; CRY1; BCLAF1; SFPQ; BLM; DEK; GTF2IRD1; RUNX1; ADNP; PSPC1; BCL10; RBBP4; IRF7; NRBF2; BATF; LPIN2; DR1; KAT7; CDK8; SUZ12; DPF2; FLNA; REPIN1; MAX; ERBB2; PURA; BASP1; DDX54; FOXC1; RAN; BRPF1; MLX; TRIM29; YWHAB; MAGED1; KDM2A; VGLL4; ITGB3BP; MBD2; RNF111; ZBTB11; BRCA1; HOXB7; KLF10; KLF6; TAF10; GATAD2A; TSG101; HIF1A; ZBTB38; TSC22D2; HMGB2; BAZ1B; NR2F6; APEX1; WWC1; RBBP7; CNOT1; HMG20A; TBL1X; RNF6; PATZ1; STAT3; COPS5; TRIM16; TGFB1I1; PCGF2; SOX4; JARID2; SMARCC1; EZH2; NCOR2; SERTAD2; BIRC2; ZNF302; ZNF131; SIX1; BAZ1A; RNF14; CBFB; RREB1; HTATIP2; ZBTB18; EWSR1; BATF3; SMAD2; SSRP1; NR2F2; RCOR1; AFF1; MED7; SOX9; BMI1; SF1; PQBP1; PHF20; HDAC1; PSMC3; SP110; ELF1; E2F3; HOXC6; MNAT1; HOXA11; HMGB1; TCF12; ELK3; ZNF217; CHD7; IFI16; CTBP2; AHR; NFATC3; TOB1; TRIP6; KDM5D; ABL1