Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08118 Cgp-60474 GSE70138 HA1E Human 24h 3.33uM EID0010
Types Number Response transcription factors
Up-regulation 702 FOXO4; ZNF224; EGR1; DAXX; ZNF695; ZNF257; ZNF264; GATA3; ZNF345; ZNF701; ZNF551; ZNF154; EMX1; HSF4; PRDM14; ZNF667; HNF4G; MAML3; ZNF362; ZNF606; ZNF682; CHD2; TWIST1; FEZF2; TBX6; ZNF391; NEUROD2; ZNF75D; HAND2; ASCL3; TBR1; SCAI; NEUROD4; ZNF235; ZNF136; ZNF688; HOXA3; ZNF586; TULP1; RFX3; CRX; ZNF549; HOXD3; RBPJL; SPI1; HLX; ZNF816; TBX1; ZNF225; L3MBTL1; PRDM9; ZNF343; PDX1; SHOX; SSX7; HEYL; ZNF117; NR5A2; ZNF155; ZNF208; THRB; MNX1; NR4A3; ESR2; PROP1; BARX1; ZNF223; THRA; FOXD3; ZFHX2; ZKSCAN8; ZNF440; SIX6; TP73; SRY; ZNF814; POU3F3; CARF; SOX18; POU6F2; ZNF471; ZNF778; EVX1; HSF1; ZNF141; RFX1; SOX21; ZNF180; MAK; CDX1; GRIP1; E4F1; WHSC1L1; ZIC4; ZNF135; GBX1; SIX5; ATOH1; ZBTB7C; ZNF331; ZNF254; ALX4; ZNF696; ZNF749; MAPK8IP1; TONSL; ZNF81; TAF1C; NR5A1; ZNF500; DOT1L; PLAGL1; NEUROG2; ZNF80; ZNF407; PRDM5; SIX3; SOX17; POU2F3; ZNF492; SOX14; FOXB1; ZNF195; SP4; ZNF304; ZNF157; FOXE3; ZNF674; GCM2; NEUROG3; SCRT1; MLLT1; NKX6-1; NFIX; GSC2; PAX1; NKX2-5; ZNF8; ZNF544; ZNF93; NEUROG1; NPAS1; ZNF771; TCEA2; REL; TBX4; TLX2; MSX2; EZH1; FOXH1; ZSCAN2; LHX3; ZNF442; ZNF112; ZNF493; TBX10; ETV2; BRDT; ZNF234; CIR1; POU1F1; ZNF573; ZNF711; ZNF41; ZNF358; HOXB8; NR6A1; TBX5; ZIC3; DCC; DLX4; ZNF124; ZNF780B; CBX7; ZNF671; VHL; NKX2-8; ARHGAP35; ATF7; EP300; MZF1; EPAS1; TAF6L; CBX4; GBX2; HOXB1; TSHZ2; ZNF205; BCL11A; ZNF214; E2F4; CCNT1; TFDP3; HES2; SIM1; SSBP3; PHOX2A; ZNF221; HMX1; ETV3; ZNF91; NHLH2; HDAC5; ASH1L; SSX3; HIF3A; ZNF611; CBX8; ZNF132; RORA; NFKB2; ZNF273; ZNF665; NR1H4; TCEA1; NEUROD6; HAND1; ONECUT1; ZNF623; ZNF613; PRDM10; LDB1; KAT2B; TCF15; NR4A2; ZKSCAN4; RORB; FOXL1; THAP3; CAMTA2; ZNF287; ZFP2; VSX1; IRF8; ALX3; TAF4B; MDM4; POU6F1; ZNF34; ZFP69B; CBX2; LHX5; POU3F4; RXRB; PAX4; TFAP2B; SKIL; VENTX; PBX2; HOXB3; TLX3; ZNF44; ZBTB44; CDX4; IKZF3; PITX3; ZNF484; OVOL2; PRDM1; PAX7; ZNF334; PRDM16; FOXD2; PAX6; ZNF197; ZNF669; ZNF550; RAX; ZNF76; MEF2D; RUNX2; MED12; ZNF506; DMRT1; HOXC8; ZFY; ASCL2; NOCT; CD3D; CBFA2T3; ZNF215; MEOX2; AR; TFAP2A; HESX1; PAXBP1; ESRRB; ZBTB7B; SOX13; KDM5C; MYNN; TEF; NKX3-2; KLF8; ZNF134; POU4F3; FOXC2; IRF6; HNF1B; FOXF2; IKZF2; ZNF529; TBL1Y; ZNF12; TLX1; ZKSCAN3; VGLL1; HOXD1; ZNF415; ZNF43; RNF2; PRDM2; KLF13; ZNF507; IKZF4; ZBTB20; EGR4; HDAC11; ZNF768; SOX1; ZNF426; PRDM8; FOXJ1; ACTL6B; TBX19; ZNF419; HBP1; BNC1; SETDB1; MEIS2; OVOL1; ERBB4; SUPT7L; ING4; EYA3; HIPK2; ZNF350; PPARA; SOX3; WNT4; THAP9; ZNF557; ZNF460; ZNF10; HNF1A; DLX6; FOXI1; FHL5; RARG; KLF15; ZNF480; LBX1; LZTR1; ZBTB3; HOXD12; HMBOX1; ZNF211; ZNF835; AIRE; CREM; MYOG; SSBP2; ZNF446; HMGXB3; SLC2A4RG; KAT2A; AFF3; SPDEF; ZXDB; IFNB1; GCM1; ZNF329; ZNF646; NR2E1; CDIP1; MAFK; TULP2; ZFPM2; NHLH1; ESRRG; ONECUT2; MED25; RORC; HIC1; ZNF675; ELK4; LIN28A; MYF5; GRHL2; HOXD13; RING1; HLF; ZNF423; SOX5; CALCOCO1; UTF1; NR2C2; HOXA6; CUX2; ZNF232; HOXC5; ZNF324B; NR1I3; MTA2; MYT1; MYEF2; DYRK1B; PAX2; ATN1; VPS72; ATF3; HNF4A; FOXP3; STAT5B; ZNF174; ZNF430; TUB; FOXN1; SMAD6; ZNF467; SUV39H2; HOXA2; ZNF286A; LMX1B; EHMT2; ZKSCAN7; SOX12; DLX5; CNOT3; CRTC1; RSF1; CEBPE; PAX3; EGR2; AFF2; SOX30; MDM2; NFKBIB; DMTF1; CALR; MBD4; MYRF; ETV7; GATA6; CDX2; PRDM12; ZNF787; CIC; KMT2D; ZNF222; APBB1; BRWD1; ZNF324; NR1I2; CREG1; BCL6; ARID5A; NACA2; RFX2; GLI1; EN1; ZNF74; TRIB3; ZNF22; ZNF562; ZBTB48; SRCAP; NAB2; TRPS1; STAT2; ZNF226; ZNF219; HMGA2; ATF6B; MXD3; IRF9; POU4F2; FEV; NFAT5; ZNF580; PHOX2B; SKI; ZSCAN32; JAK2; SNAI1; MAP3K10; TAF1; MED31; NR4A1; GFI1; BARX2; PRRX1; POU2F2; MAF; FOXF1; GLI2; KMT2B; GTF2A1; ZNF710; FOXA2; ZNF337; SHOX2; PITX1; ZNF556; LITAF; RXRG; ZBTB43; ZNF571; ZSCAN18; IRF1; HIVEP3; TDP2; AES; STAT4; ZNF184; POU2F1; CREBL2; ZNF3; ZNF227; GATA1; CREB5; NLK; SUPT3H; PHF1; NR1H3; CIITA; CERS4; NFATC4; ZBTB17; PBXIP1; ARNT2; ZNF813; MYOD1; TERF1; LHX2; ZNF253; INSR; EHMT1; MYCN; YBX2; TAF7L; TBX21; BAZ2A; SOX11; TCF21; HOXB5; ELF2; GLI3; OLIG2; NEUROD1; ZFP30; HDAC9; TGFB1; NFATC1; ZNF268; PRRX2; ZNF654; ZNF14; ALX1; TULP3; ZNF85; MLXIPL; ZNF770; PITX2; ZNF536; YEATS2; THAP7; SNAPC4; IRF3; TCF7L2; SALL1; ZNF444; PRDM13; ID4; SALL2; BCL3; CERS6; ST18; TOX; ZNF175; BRD2; POU5F1B; SUPT5H; SREBF2; HEY1; TFEB; CSDC2; ZNF354A; DBP; ZFP36L2; BNC2; ZNF394; RBL2; TFEC; HOXB13; MXI1; HOXA4; CHD4; HIC2; EN2; MYF6; AHR; NKX2-2; KLF1; EGR3; CHD3; IRX4; SP140; TFDP2; KDM4C; TAL1; ZNF107; AEBP1; ZNF165; ERF; TEAD3; NFIC; ZNF532; TAF6; MKL2; BHLHE41; ZFHX3; ETV5; FOXL2; CAPN15; ZNF239; CRYM; FOXA1; MED15; NR1H2; CAMTA1; WT1; BRD4; NR2C1; GFI1B; ZNF587; ZKSCAN1; SAP18; ZNF589; MYT1L; MNDA; ZNF512B; SPIB; HHEX; TCF7; FOXG1; MYCL; SP140L; FUBP1; ZSCAN31; JUP; OSR2; ARID1A; ZNF652; HOXB2; MSC; TRIM22; ZNF160; PBX1; ZBED2; TFCP2; MEF2C; HEY2; ZNF83; ZFHX4; CTNNB1; KLF4; FOS; TCF4; DDIT3; BACH2; STAT5A; NANOG; MECOM; EMX2; STAT6; TCEB2; HMGA1; IKZF1; FLI1; E2F5; ISL1; TXNIP; ZNF721; NR2F1; SMARCA1; SOX2; EYA1; MEIS1; INSM1; SNAI2; ESR1; ELF3; RXRA; MSX1; E2F2; SATB2; GATA2; ETV1; ID3; ADRB2; TBX2
Down-regulation 181 CCNA2; NFKBIA; FHL2; TLE1; HNRNPD; NUP62; XBP1; SUV39H1; PUF60; ECD; HDAC2; TP53; EED; PAX8; RB1; UBE2I; CCNC; USP22; MED27; FOXO3; FOSL1; MYBL2; TBP; VEZF1; MYC; TRIM32; DEK; NPAT; CRK; REST; PIAS2; TCERG1; NCOA6; CNOT1; MED1; TAF9; WHSC1; PATZ1; SNW1; CRY1; KAT7; BCLAF1; SETD2; MAGED1; RNF138; MBD2; BAZ1A; RBM14; MED6; JARID2; YWHAB; ATF1; GTF2A2; BHLHE40; PHF20; BRD3; SFPQ; ERBB2; MLX; SMAD3; CBX3; SMARCA5; EDF1; FOXJ3; ZBTB24; DPF2; NKX3-1; ZNF672; SCAND1; SIX1; CBFB; GATAD2A; AATF; SAP130; RFC1; SMARCE1; PCGF2; TRIP4; HMGB2; RBBP4; BRCA1; RREB1; HIF1A; ING2; BATF3; FLNA; SF1; ANKRD1; CTCF; DR1; PPRC1; RNF111; CCDC59; ZMIZ1; RBL1; TRIM29; CDK7; HOXC6; CDYL; ASXL1; PSMC3IP; NELFB; BIRC2; RAN; RUNX1; ZNF146; ZBTB18; ITGB3BP; DDX5; NR2F2; TAF10; AFF1; CTR9; ELK3; MAX; TSC22D2; RBM39; BMI1; CNOT6; KLF10; BASP1; ASH2L; ORC2; BRD8; ZBTB1; HOXA5; HSBP1; MTDH; PLAGL2; HOXC10; CREB3L1; TCF12; KAT8; BCL10; KDM2A; PREB; NR2F6; PBX3; NRIP1; BLM; SOX4; EWSR1; ARID4B; ZNF410; ENO1; SERTAD2; MNAT1; SMAD2; RBBP8; HOXB7; TOB1; REPIN1; XRCC6; SP3; GTF2IRD1; RARA; E2F3; ATF4; PQBP1; ZNF302; TBL1X; PURA; ELF1; SMARCA2; LPIN2; RCOR1; FOXD1; ZMYM2; SAP30; BTG1; ZFP36L1; CHD7; NCOR2; KLF6; LEF1; FOXC1; CTBP2; DACH1; KDM5D; THAP11; NFATC3