Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08052 Gsk-1059615 GSE70138 HA1E Human 24h 3.33uM EID0010
Types Number Response transcription factors
Up-regulation 630 FOXO4; TCFL5; NFKB2; ZNF695; SSX1; ZNF701; ZNF257; ESRRG; ZNF141; ZNF492; RARG; ZKSCAN8; WHSC1L1; PRDM5; ZNF391; IRF4; RFX3; SP140; MDM2; ZFY; ZNF197; CHD2; NEUROD4; FOXA1; ZNF132; SSX7; ZNF493; NFKBIB; ZNF34; EZH1; TBR1; EMX1; ZNF286A; NFAT5; ONECUT1; TAF4B; ZBTB7C; BATF; ASH1L; NR6A1; ZNF471; ZNF623; ZNF780B; SSX3; ZNF440; ZNF107; ZNF442; ZNF667; SMARCD3; BNC2; ZNF225; TCEA2; EYA3; MDM4; SCAI; ARID3A; IKZF2; ZNF81; IL16; PRDM9; HOXC13; ZNF214; ZFHX3; RUNX2; PAX4; MAML3; CBX2; ZNF80; ZNF407; ZNF460; ZNF682; ZNF208; HNF4G; ZNF223; ZNF749; RFX2; ZBTB44; DOT1L; HIVEP1; THRB; POU6F1; BRDT; ZNF674; MAK; ZKSCAN4; NKX6-1; POU6F2; ARHGAP35; ZNF224; KDM5B; ZFPM2; PAX9; CREM; L3MBTL1; GCM2; RBPMS; ZNF157; TP73; VHL; GLI2; ZNF778; ZNF117; AR; IFNB1; ZBTB39; PRDM14; SUV39H2; MNX1; MYEF2; SP4; THRA; JAK2; ZNF155; ZNF343; NEUROD1; SOX4; ZNF696; ZNF549; ZNF814; FOXD3; ZNF362; CBX8; NR3C2; ETV3; PLAGL1; SOX21; ZNF710; POU1F1; ZNF248; ZNF41; TAF1C; ZNF264; ZNF235; ASCL3; ZNF816; SHOX; SRY; EHMT1; MED12; GCM1; SSBP2; CCNT1; ZNF287; ZIM2; GFI1; STAT2; ZNF282; ATF7; ZNF557; ZBTB3; ZNF75D; ASCL2; ZNF334; TLX3; POU3F4; BARX2; POU2F3; HR; GRHL2; KLF8; EGR4; FOXB1; SOX30; PLAG1; ONECUT2; TRIM25; HOXB8; SKI; ZNF273; OVOL1; GRIP1; ZNF221; MLLT1; FOXD2; ZKSCAN7; ABT1; TBL1Y; NKX3-2; NR2F1; ZNF236; TFDP3; PRDM2; AFF2; AFF3; ZNF234; ZNF652; HESX1; CARF; PAX2; TCF21; ALX4; NR5A2; HOXC11; CBFA2T3; LZTS1; ETV6; ZKSCAN3; RSF1; FEZF2; POU3F3; ZNF415; ASCL1; ZNF136; RUNX3; KLF3; MSX2; ZIC4; LHX3; NR4A2; ZNF384; MXD3; SOX14; GSC2; TULP4; ZFHX2; ZNF550; BRF2; ZXDB; NEUROG3; BCL10; HDAC6; TAF7L; TBX5; WNT4; HOXA2; EGR3; PKNOX1; ING4; NEUROG2; THRAP3; ELF2; ARID3B; NEUROD2; ZNF552; THAP9; HIPK2; RBPJL; CIITA; KAT2A; HAND1; ZNF76; MNDA; TSHZ2; POU4F2; ZNF154; ZFP37; HMG20B; PAX3; ZNF254; TEF; EZH2; ZNF324B; PAX7; TULP1; GATA6; HMGA2; VENTX; PCGF2; E4F1; ZNF484; CTNNB1; KLF13; ZNF639; ZNF337; IKZF3; YBX2; NR0B2; PGR; GATA4; FOXE3; PDX1; FOXL2; KDM5A; NOCT; ZBTB6; DMRT1; KMT2D; PROP1; ZFP2; SCRT1; ZNF835; ZNF112; CBX7; NLK; SSBP3; ZNF79; TFAP4; ZNF253; TAF6L; CAMTA1; ZNF345; HOXB3; RORC; HAND2; ZNF142; MLXIPL; PPARD; MEN1; NRF1; ZIC3; TSG101; PKNOX2; HEYL; ZNF324; HES2; NR1I3; TRIP11; SPDEF; TFAP2B; ZNF33B; HSF4; NR2C2; LMO1; SPIB; ZSCAN9; DLX4; ESR2; NEUROG1; ATOH1; WT1; ZNF571; NKX2-1; SP1; PRDM1; ZNF205; ZNF212; MAPK8IP1; PITX2; HOXA6; HIVEP3; ZNF180; HLX; PPARA; ZNF556; CERS6; ZNF135; EGR2; SUPT4H1; MYC; TBX4; ZNF711; VDR; TULP2; CBX6; HNF1B; ZNF165; ZNF771; POU2F1; SIX3; MYT1; DLX6; HHEX; CRX; AFF4; NCOA2; ZNF507; TBX6; DNAJC1; MLLT10; ZNF506; ZNF586; FOXH1; TONSL; KDM4A; DCC; HOXD3; PEX14; POU4F3; SOX5; IRF6; PITX1; SMAD5; NRL; BRWD1; ZNF613; KAT5; PHIP; ZHX3; CSDC2; RING1; LZTR1; DDX54; TBX1; DDX17; TLX1; TEAD1; EP400; NR4A3; BANP; ZNF587; ZNF43; ZNF500; MSC; PHOX2A; MYCL; ZBTB32; TRPS1; ZNF467; PHOX2B; MED23; ZNF764; NAB2; CTR9; OVOL2; SETDB1; ZBTB16; TLX2; LHX5; GLI3; PRMT2; ZNF675; HIC2; LIMD1; SIM1; SOX12; PRDM13; GTF2I; STAT4; ARID1A; KAT2B; MED14; UBTF; ZNF250; TGFB1I1; SALL2; ETV2; ZMIZ2; TLE2; TRIM27; EGR1; TWIST1; GBX2; ELF3; FEV; MED24; ZNF85; HOXB1; NR1H3; FHL5; HDAC11; TAF4; HOXC4; ID4; CREB3L2; ZNF226; POU5F1B; NFE2; LPIN2; POU2F2; STAT5B; ZNF770; ZNF74; SOX18; HOXD12; BACH1; RHOA; BNC1; PIAS3; MEIS1; TAF1; SNAI2; SIX2; ZBTB7B; RBPJ; BARX1; HMBOX1; ZNF329; NHLH2; EN2; ELK1; CDIP1; MAFK; RORA; EVX1; BRPF1; ZSCAN31; BLZF1; ZNF304; HIC1; SOHLH2; HINFP; ZNF175; ZNF692; NANOG; SNAI1; NFE2L3; MXD1; RFX7; ALX1; ELK4; KLF15; NKX2-5; ZNF671; ST18; HOXC8; ZNF184; MTA2; MAX; NR1H4; KAT7; HIVEP2; ZNF10; REL; EBF2; TBX19; ESRRA; PEG3; ZNF93; MYF6; MECOM; CBL; TRRAP; ZNF267; ASH2L; TXNIP; NFKB1; PRRX1; MEIS2; PBXIP1; HOXD1; FUBP1; JUP; HDAC5; FOXI1; TBX21; NFYA; GFI1B; GATA1; TSC22D4; KDM5D; HIF3A; E2F8; WWP1; ACTL6B; TBPL1; SIAH2; LMCD1; ARID4A; CDYL; ELF5; MBD4; ELF4; E2F6; SMARCA1; MYT1L; DNMT3B; CXXC1; TRIM33; TRIM28; SP2; PPP1R13L; ZNF512B; ATN1; KMT2A; TRIM24; FOXJ1; MTDH; PROX1; CALCOCO1; FOXN3; VGLL1; BAZ2B; TCF7L1; SOX3; ERBB4; HLF; ISL1; BCL11A; STAT3; MEOX2; MYB; BCL6; ETV1; TRIB3; CHD9; TBL1X; HOXB2; TGIF1; ADRB2; AES; RERE; BACH2; BAZ1B; CERS4; TLE4; CITED1; CALR; TOX; ZBED2; ETV5; SHOX2; NFIC; PAX5; FOXD1; LIN28A; KLF1; STAT5A; SERTAD2; HMGB2; TBX2; TSC22D1; FOXA2; INSM1; PPARG; PAX6; PIR; TFAP2C; SUB1; OSR2; ARNT2; AFF1; SOX17; SMARCA2; TCF7; PQBP1; SOX11; SP110; SPEN; IRF7; FOXF2; MYRF; KLF10; IKZF1; TRIM22; FOXG1; MEF2C; GATA2; CEBPA; SOX2; E2F2
Down-regulation 151 CRK; TLE1; ZMYM2; ARID5B; ATF4; HNRNPD; MNT; RBM39; CNBP; MED27; NFKBIA; CEBPG; TAF9; SF1; SCAND1; CCNC; PSPC1; MAZ; NKX3-1; HMGB1; YWHAB; CEBPB; TCF3; TAF10; VEZF1; NFATC4; CNOT6; ERBB2; NCOA6; CRY1; IKBKAP; BRD4; BASP1; C1D; XRCC6; STAT1; RUVBL1; HSBP1; SUMO1; ZNF140; MED1; TFAM; GCFC2; SRCAP; ZNF562; PTRF; CBX3; FLNA; MXI1; DDX5; ARID4B; CTBP2; ZNF593; CHD1; GATAD2A; C1QBP; BIRC2; CREB3; FOSL1; PSMC3IP; NFIB; WWC1; ZFP36L1; SMAD3; ZNF266; KDM2A; TFDP1; CDK8; HDAC9; ZEB2; ZNF302; TTF1; ORC2; KLF7; ID3; BRCA1; PA2G4; TRIM29; RNF138; SFPQ; ATF5; DR1; RNF6; GTF3A; EDF1; HDGF; ING3; CEBPZ; MBD2; ERG; SNW1; NPAS2; ZZZ3; HIF1A; ARNTL2; FOSB; RFX5; THAP4; FOSL2; NR1I2; ZMYND8; TRIM16; DACH1; HOXA10; TSC22D2; BBX; DDIT3; ZBTB38; MAFF; ID2; BCLAF1; NR2F2; BTG1; ZBTB18; TERF2; TOB1; ELF1; MSX1; ZSCAN18; ADNP2; ZNF468; BAZ1A; JUND; MAFB; RAN; TSC22D3; KLF2; PPARGC1A; SMAD1; VPS72; CARHSP1; KLF11; SALL1; RCOR3; DMTF1; NFATC3; SATB2; SAP30; BCOR; CHD7; ID1; KLF5; BCL11B; YBX3; KLF6; HOXC10; TOX3; ATF3; KLF4; CREB1; TRIP6