Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08034 Alvocidib GSE70138 HA1E Human 24h 0.12uM EID0010
Types Number Response transcription factors
Up-regulation 629 ZNF264; CEBPD; MAML3; FEZF2; ZNF695; CHD2; ZNF154; NR4A2; MAK; NFKB2; SOX17; ZNF701; ZNF551; ZNF391; CARF; OVOL2; SOX5; L3MBTL1; SCAI; ZNF224; SRY; ZNF440; SPI1; POU6F2; ZNF257; ZNF606; PRDM14; ZNF345; ZNF75D; ZNF682; ZKSCAN8; RFX3; ZKSCAN4; SOX18; ZNF304; ZNF749; EGR1; ZFPM2; THRA; RFX1; PRDM9; TP73; RBPJL; ZNF816; DOT1L; CIITA; SSX7; MDM4; PBX2; SHOX; TBR1; ZNF117; POU2F3; PDX1; NEUROG2; NEUROD2; HIF3A; TULP1; SCRT1; FOXD3; ZNF471; ZNF549; NKX3-2; ZXDC; CBFA2T3; ZNF221; ONECUT1; TBX1; IKZF2; VENTX; ZNF415; REL; EMX1; ZNF362; ZNF492; ZNF225; NR5A1; HNF4G; ZNF667; ZNF136; THRB; ASCL3; FOXE3; FOXO4; ATOH1; ZNF814; BRDT; HIPK2; HDAC9; MLLT1; SOX1; ZIC3; ZNF343; ZNF407; TCEA1; ZNF573; ZNF467; HOXB8; TBX6; NHLH2; ZNF235; NR6A1; IRF6; NFIX; ALX4; ZNF674; VGLL1; PRDM16; ZNF254; ZFY; HOXC5; BCL11A; ZNF688; IRF1; ARID3A; HES2; NEUROD4; ZNF623; ZIC4; GBX1; TWIST1; SOX21; ZNF778; ZNF215; SIX6; ZFHX2; POU4F3; ZNF208; NFATC4; NKX6-1; ZNF80; VHL; ESR2; ZNF223; GSC2; SOHLH2; KMT2D; FOS; ZNF180; ZNF287; ZNF214; GBX2; PROP1; ZNF155; RNF2; PRDM5; HOXA3; TONSL; ATF6B; E2F4; NFKBIB; FHL5; TEF; JUP; NR2E1; MSX2; NACA2; ZNF273; HEYL; PEG3; ATF3; MYEF2; ATF7; ZNF157; TAF4B; ZFP2; ZNF550; ZNF536; NR5A2; KLF8; ZNF780B; TBX5; GCM2; IKZF3; SOX14; GRIP1; ZNF442; PAX4; KAT2B; HOXD12; NEUROD6; ZBTB7C; CRX; CBX4; FOXA1; AR; ZNF484; SP4; PPARA; HOXB1; ZNF81; POU3F3; LHX3; NEUROG3; TLX3; HAND1; NEUROG1; ZSCAN9; NOCT; THAP9; CEBPE; ETV2; POU1F1; ESRRB; OVOL1; RORB; ERBB4; ZNF544; HESX1; TULP2; MYCL; BARX1; HOXD3; ZNF91; DCC; MAPK8IP1; NR4A3; RSF1; NR2C2; MYF5; PARP1; SIX5; ZNF234; TBL1Y; ETV3; ZNF507; ZNF423; ZNF710; MYT1; ZXDB; NPAS1; CDX4; ZNF493; WHSC1L1; HAND2; TFDP3; ZNF141; FOXJ1; ZNF835; AFF2; CDX1; PAX3; AFF3; EHMT2; ZBTB48; HNF1A; VSX1; ZNF41; ZNF480; FOXD2; ZNF132; TCEA2; LBX1; ZNF506; HBP1; ZIM2; FOXL1; ZNF556; ZFP69B; PAX7; MDM2; DLX6; NKX2-8; TBX10; POU4F2; FOXB1; SOX13; TFAP2A; HDAC5; ZNF675; ASCL2; ASH1L; ST18; HOXA2; TLX2; HSF4; ING4; RFXAP; POU3F4; ZNF613; SUV39H2; KDM4C; ZBTB3; ACTL6B; AIRE; ZNF43; ZNF205; NR1H4; UTF1; ZNF135; SALL2; ALX3; ZNF142; DLX2; CBX8; DMRT1; ZNF771; ZNF10; ZBTB20; ONECUT2; FOSB; TBX4; TAF6L; ZNF460; ZNF764; ZNF331; GTF2A1; NEUROD1; PRDM2; EP300; SKI; PAX1; POU3F2; TLX1; SOX3; ZNF711; ZNF197; ZSCAN2; CD3D; ZNF44; ZNF696; NKX2-5; HOXD1; SKIL; LYL1; MBD4; TCF21; CBX7; MEOX2; MED31; HOXA6; ZNF671; GATA3; MYC; ZNF334; WNT4; PKNOX2; HOXD13; FOXJ2; ZNF8; CDIP1; RORC; TSHZ2; JAK2; HIC2; ZNF85; FOXH1; EZH1; HOXB3; ZBTB44; SIN3B; HNF1B; ZNF350; LMX1B; DLX5; SSX3; ZNF177; ZNF93; TTF2; MEF2D; LDB1; HNF4A; ZNF500; KLF3; MYNN; ZNF669; BRWD1; PRDM12; PITX3; SOX30; ZNF358; ZNF557; FOXN1; SUPT3H; CREB5; HOXB5; ZNF665; MAFF; PAX6; MNDA; ARNT; LHX5; PRDM10; ZNF174; ZKSCAN3; ZSCAN31; ZNF107; MLLT10; RUVBL1; MECP2; LHX6; ZNF426; BNC1; CBX2; HEY1; MAFK; ZNF14; PLAGL1; RARG; INSR; IKZF4; BRCA1; SRCAP; ZNF770; NHLH1; LZTR1; SPDEF; CERS6; ZBTB6; FOXC2; HOXB13; EVX1; ZNF552; HIVEP3; LIN28A; MZF1; ZNF112; SUPT7L; TUB; MTA2; SHOX2; NFX1; ESR1; HMBOX1; ZFP37; DLX4; EMX2; HLX; STAT2; MEIS2; CIR1; RFX2; ZNF74; HIC1; SSBP3; KLF15; TRIB3; CREG1; ARNT2; HDAC11; EBF2; ZNF562; SP140L; PFDN5; ZNF611; ZNF219; ZBTB7B; CREM; TAL1; EYA3; FOXF1; NR1I2; CALR; ZNF571; THAP10; HOXC8; E2F1; TBX19; EPAS1; BHLHE41; MED25; TGFB1; SIX3; GRHL2; HLF; NR0B2; ZNF253; POU2F1; NR0B1; IRF8; CNOT3; SUPT6H; TAF7L; NR1I3; FOXP3; PIAS4; ARRB1; MXI1; TOX; ATN1; ZNF211; HEY2; GCFC2; VPS72; PHOX2B; TFEC; MECOM; EGR4; RAX; ZNF239; TFDP2; PITX1; PRDM13; NR4A1; ZNF529; ZNF236; ZNF787; E2F5; CALCOCO1; ZNF528; HMGA1; ESRRG; PEX14; ZNF195; SMARCB1; GFI1B; SLC2A4RG; NFIC; CNOT2; POU5F1B; NR3C2; YAP1; CAMTA2; LEF1; ZNF124; ZFHX3; ZNF248; ZNF813; SP140; MDFI; ELF3; ID1; NANOG; MED14; TOPORS; MSX1; ZNF165; NKX2-2; ZNF3; BHLHE40; FOXF2; AEBP1; TCF4; ZNF222; BCL6; ELK4; WT1; ZKSCAN7; FOXL2; FOXA2; NFAT5; BAZ2A; CUX2; GLI3; CREBL2; ZBED2; CAMTA1; PRMT2; TEAD3; GLI2; HIRA; RING1; ZNF654; BACH2; ARID5A; MYRF; PGR; ZNF232; ISL1; PRRX1; ZNF468; NFE2; ZNF83; ZNF268; CRYM; KLF11; GATA1; ZSCAN18; ZNF175; PRDM1; CNBP; PNRC1; ZNF133; RORA; CERS4; HHEX; DBP; E2F8; RNF141; TBX21; PEX2; MYT1L; TULP3; ID3; KLF7; NR1H3; EHF; TRIM24; PAX5; IRF9; ZNF184; ZMYND8; PLAG1; BNC2; TRIM22; FLI1; KAT6B; EGR3; PBXIP1; WWP1; MEF2C; TRPS1; POU2AF1; ZNF532; GATA2; NR2F1; INSM1; NFE2L3; SOX2; EYA1; SOX11; ZNF652; SPIB; FOXG1; KLF2; GATA6; OSR2; RBFOX2; JUNB; ZNF589; HOXB2; E2F2; IFI16; TXNIP; AHR; IKZF1; SATB2; SNAI2; MEIS1
Down-regulation 185 PAX8; FHL2; CCNA2; PUF60; CRK; TLE1; NUP62; SUV39H1; CENPF; ECD; EZH2; XBP1; HNRNPD; USP22; TBP; FOXO3; VEZF1; TCERG1; SNW1; UBE2I; NFIL3; RBM14; CRY1; DNAJC2; BCLAF1; TP53; ZNF146; KAT7; ATF1; EED; DEK; BRD8; TRIM32; BRD3; SMARCA5; SOX4; TAF9; HDAC2; PTTG1; CCNC; RBPJ; SMAD3; ADNP; ZBTB24; HOXC6; HOXA10; MED6; REST; CDK7; NPAT; SMARCE1; MED1; NFE2L1; NCOA6; BLM; HOXA5; PCGF2; NPM1; AATF; MLX; NRIP1; ING2; PATZ1; ZFP64; TRIM29; DDX54; GTF2IRD1; SFPQ; CNOT1; RNF4; MED13; MBD2; HMGB2; RNF111; AFF1; DDX5; ZBTB1; ELF5; SUZ12; TCF20; ZNF263; MAGED1; EDF1; ZMYM2; CTCF; BASP1; ZNF672; GTF2A2; ARNTL; CHD1; RBBP4; BAZ1B; ARID4B; RAN; FOXK2; ZNF410; ENO1; ZNF266; NELFB; HOXB7; HOXC10; STAT3; TBL1XR1; ZNF189; ZMIZ1; HMGB1; SIX1; RBPMS; NCOA4; CEBPZ; TGFB1I1; RNF138; NRBF2; SMAD2; PREB; TFAM; CBX3; YWHAB; SF1; ID2; ZBTB11; BAZ1A; PURA; FOXJ3; ITGB3BP; CCDC59; ZBTB38; WHSC1; PHF20; COPS2; BATF3; SP3; SSRP1; PSPC1; PQBP1; NCOR2; NAB1; HSBP1; NR2F2; TBPL1; NFIB; JARID2; SOX9; BMI1; TCF12; RNF6; ATF5; SAP30; REPIN1; VGLL4; RCOR1; TSC22D2; CTBP2; IRF4; SCAND1; ATF4; BATF; RELA; FLNA; CENPB; ERBB2; ING3; APEX1; TRIM28; UBE2B; LMCD1; PBX3; IKBKAP; FOXC1; SOX10; TOB1; ZBTB18; ID4; ZNF217; ELF1; FOXD1; RFX5; MNAT1; ASCL1; BTG1; KLF6; MYBL1; THAP11; NR3C1; ABL1