Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08033 Alvocidib GSE70138 HA1E Human 24h 0.37uM EID0010
Types Number Response transcription factors
Up-regulation 604 SSBP2; EGR1; PRDM14; PEG3; MAML3; CHD2; ZNF688; ZNF154; ZNF816; ZNF606; ZNF391; SPI1; ZNF701; ZNF695; NKX3-2; RFX1; ZNF264; TWIST1; SSX7; ZKSCAN8; ZFHX2; ZXDC; ZNF224; TP73; RBPJL; ZNF75D; MDM4; SOX5; TCEA1; L3MBTL1; ZNF835; THRB; ZNF667; NFKB2; SRY; ASCL3; SCRT1; OVOL2; NFKBIB; KMT2D; HOXB1; ALX4; NEUROD2; ZNF551; GBX1; SOX21; FEZF2; TULP1; HEYL; NHLH2; ZNF682; SIX6; LHX3; VENTX; RFX3; HOXC5; POU6F2; PAX1; SOX1; CARF; HNF1A; HIF3A; BCL11A; ATF6B; ESR2; PRDM9; ZIC3; ZNF549; TBX6; ZNF135; ZNF221; PROP1; MAK; ZNF345; CD3D; PRDM5; HNF4G; ATOH1; NFIX; NEUROD4; NR6A1; MED12; DOT1L; EMX1; PDX1; ZKSCAN4; NEUROD6; NEUROG1; DLX6; HOXB8; ZNF550; HESX1; TBR1; ZNF223; THRA; PAX7; FOXD3; IKZF2; ZNF440; NR5A1; BRDT; ZNF471; FOS; NEUROG2; SALL2; NR0B2; AFF2; ZNF235; FOXE3; ZNF467; ZNF343; ATF7; NHLH1; WHSC1L1; ACTL6B; AR; POU2F3; TBX19; ZNF749; DCC; ZNF362; PRDM16; CIITA; ZSCAN2; ZNF415; TCEA2; BARX1; JUP; HOXD3; MLLT1; ZNF671; NEUROG3; TFDP2; FOXH1; ZFY; TLX1; HDAC9; TLX3; HOXA3; HIVEP3; POU4F2; ZNF155; ZNF334; SSX3; ZNF771; NKX6-1; GRIP1; OVOL1; RORB; SP4; SRCAP; ZKSCAN7; HES2; NR4A2; HIPK2; MEOX2; E2F4; ZNF544; HDAC5; ESRRB; ONECUT1; ZNF528; SCAI; DLX5; SHOX; ASH1L; AIRE; PAX6; HOXB5; TBX5; KLF8; ALX3; ZNF208; MAPK8IP1; ZIC4; ZNF814; NEUROD1; ZIM2; ETV2; LBX1; SSBP3; RORC; CDX4; ZNF117; TEF; NOCT; MDM2; SOX14; NACA2; TAF6L; ZNF507; ZNF225; MZF1; ZNF254; KLF15; NKX2-5; HOXD12; PPARA; VGLL1; ZFP2; GSC2; PRDM2; FOXL1; ZNF484; POU1F1; ZNF132; ZNF257; ING4; ZNF407; WNT4; ZNF180; ZNF573; ZNF287; ZNF442; PAX3; SIX5; PRDM12; MYT1; RAX; SOX18; TONSL; EPAS1; POU4F3; ETV3; MED31; RARG; ZFP69B; HAND2; SOHLH2; PBX2; VSX1; NR1H4; NFATC4; HNF4A; ZFPM2; GBX2; NR2E1; TBL1Y; TAF4B; POU3F3; GTF2A1; ZNF174; ZNF480; ZNF157; EHMT2; ZNF136; EYA3; ZNF674; MAF; ZNF214; CRX; SHOX2; ZBTB20; TULP2; NPAS1; ZNF215; SKIL; CEBPE; TBX1; FHL5; CEBPD; MSX2; SOX17; ZNF81; MNX1; ZBTB7B; ZNF493; HNF1B; POU3F2; GCM2; ZNF665; CREM; ZNF197; ZNF304; ZSCAN9; ZNF780B; ZNF205; NR5A2; ST18; ZNF492; ZFP37; AEBP1; FOXJ1; POU3F4; REL; SIX3; CBX8; CCNT1; PRDM1; IRF6; HOXC8; LMX1B; ZNF80; CDIP1; HSF4; KAT2B; RSF1; SKI; ZNF423; ZNF8; TSHZ2; DMRT1; ZNF711; STAT4; FOXP3; FOXB1; ZNF93; ZNF35; ASCL2; HOXA2; TFAP2A; PRDM10; MYCL; GCM1; ZNF142; ZNF669; ZNF331; ZNF274; HAND1; CBX2; ZNF141; PAX4; TFDP3; HDAC11; TAL1; ZNF536; VHL; HBP1; POU6F1; HLX; IKZF3; ZNF43; ZNF778; CDX1; SOX3; ZBTB7C; TLX2; TBX4; PAX2; UTF1; ZNF675; MED25; HMX1; VAX2; TUB; EGR4; FOXN1; ZNF710; GRHL2; IKZF4; RFX2; ERCC2; LIN28A; HOXA6; ZXDB; ZNF41; PHF8; ZNF273; EZH1; SUPT3H; ZNF552; HOXD13; MAFK; ZBTB48; NR1I3; ZNF556; DBP; ZNF219; SUPT6H; THAP9; ZSCAN18; NFAT5; ZNF44; ZBTB3; EVX1; RUVBL1; EN2; TCF21; ZNF500; CREG1; ZBTB44; PITX1; ZNF124; MECP2; ZNF76; ONECUT2; MNDA; PRDM8; DLX4; HOXD1; ZKSCAN3; FOXN2; MYNN; NRL; ZNF460; MTA2; MECOM; GATA1; TBX10; CBX7; LHX5; FOXJ2; STAT2; IRF8; LEF1; ESR1; FOSB; ZNF764; NKX2-8; CIR1; ARNT2; TAF1; PITX3; BNC1; ZNF611; KLF3; SPDEF; CBFA2T3; ZNF112; CERS6; POU5F1B; FOXA2; EBF2; ZNF623; ZBTB39; CALCOCO1; AFF3; ZNF506; CBX4; MAP3K10; MXD1; RING1; SP1; ZNF211; GCFC2; EN1; TAF7L; MYRF; LZTR1; NFX1; ZNF10; ZNF253; TGFB1; FOXF1; ZNF768; CALR; ZSCAN31; EP300; SUPT7L; JUN; HMGA1; ZNF222; PKNOX2; SLC2A4RG; HDAC6; GFI1B; ATN1; ZFP30; THAP10; ZNF175; MBD4; LYL1; HIC1; ESRRG; SP140L; LHX6; INSM1; CBL; SMARCB1; ARL2BP; SOX11; BCL11B; CUX2; NFIC; NFE2L2; PBX1; PPP1R13L; MEIS2; TRPS1; FOXA1; ATF3; ARRB1; RORA; SNAI1; ZNF770; FOXF2; SMARCA4; GFI1; ZNF532; ZNF350; TBX21; ZFHX3; CRTC1; ZNF85; INSR; ZNF562; DLX2; ETV5; NR4A1; YBX2; ZEB1; KLF1; CREBL2; SOX13; ARID5A; HMGA2; HOXB13; PFDN5; RBL2; BRF2; ZNF239; SMAD5; EMX2; AES; TXNIP; SOX15; ERBB4; IRF1; ZNF329; MAFF; NFE2; MED14; TFEC; HOXD11; BHLHE41; WT1; KLF12; NR4A3; FOXL2; TEAD3; ZNF580; LDB1; TCF4; CNBP; RNF141; BAZ2B; POU2AF1; HOXD10; NANOG; ZNF133; PIR; PRRX1; NKX2-2; HOXB2; CNOT3; PEX2; HLF; PLAGL1; ZNF226; ZBED2; ISL1; TRIB3; PHOX2B; RBFOX2; PBXIP1; ARNTL2; MXI1; MYCN; CTNNB1; YAP1; NR0B1; PLAG1; ID1; TCEB2; HEY1; ZNF529; TOX; SALL1; ZNF91; SOX2; JUNB; SSX1; NR1H3; SMARCA1; EGR2; IKZF1; TERF1; GTF3A; MEF2C; EYA1; E2F5; NFE2L3; SATB1; CRYM; FOXG1; ID3; SPIB; TRIM22; BACH2; HOXB6; NR2F1; LITAF; MSX1; MEIS1; CEBPA; ZFP36L1; ELF3; ZIC1; GATA6; ID4; E2F2; OSR2; GATA2; ETV1
Down-regulation 196 CCNA2; PUF60; SUV39H1; FHL2; ECD; CRK; CENPF; PAX8; NUP62; TCERG1; HOXA10; TLE1; SMARCA5; HNRNPD; USP22; ADNP; TAF9; SNW1; XBP1; RNF4; FOXO3; UBE2I; SMAD3; EZH2; TRIM32; FOSL1; MYBL2; ING2; NFKBIA; ARID4B; ARID5B; ZNF146; SOX4; CDK7; DNAJC2; RBM14; CRY1; PRPF6; CBX3; NPAT; NFIL3; ASXL1; HOXA5; CTR9; DEK; ZNF263; RNF138; NCOA6; WHSC1; PATZ1; ZNF266; VEZF1; AATF; ZBTB1; BASP1; SUZ12; HMGB2; BRD3; TRIM27; MED17; SAFB2; REST; BAZ1A; PPRC1; BLM; ZBTB18; DDX54; FOXJ3; EED; SFPQ; CCNC; SETD2; ZMYM2; ZBTB11; ZNF672; MED6; ATF1; TAF5; TSC22D2; BRCA1; KLF6; CHD1; RNF111; PTTG1; NELFB; BRPF1; DDX5; ZNF410; CCDC59; PLAGL2; PRDM4; NPM1; CEBPZ; ZBTB7A; NRIP1; RBL1; MAX; ZNF217; RBM39; CDYL; MED1; HDAC2; MBD2; SCAND1; HOXC6; JARID2; CTBP2; PSPC1; ELF1; BRIP1; ZNF281; NFE2L1; RAN; ARNTL; TAF4; SMAD2; NKX3-1; EDF1; SOX9; FOXK2; ITGB3BP; HOXC10; DR1; SMARCE1; RBPJ; REPIN1; BRD8; MED13; CEBPB; RNF6; PURA; RREB1; RCOR1; PHF20; BCLAF1; ZNF148; NR2F2; BATF; HOXA11; NRBF2; RBBP4; MED4; NFKB1; TBL1XR1; KLF4; STAT3; CTCF; RARA; MTF2; ENO1; SAP30; E2F8; GTF2IRD1; BTG1; NR2F6; ZMIZ1; YWHAB; AFF1; BMI1; KAT8; ELF5; SERTAD2; HTATIP2; PCGF2; ELK3; BHLHE40; HMGB1; ING3; RUNX1; KLF10; E2F3; SMARCA2; FOSL2; ILF2; PQBP1; TCF12; FLNA; RBBP8; SIAH2; ZBTB38; TGIF1; TBX3; LMCD1; TLE4; NCOR2; KLF2; MAFB; MNAT1; MYBL1; SMAD7; KLF5; NFIB; TOB1; TRIP6; NR3C1; ABL1