Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08032 Alvocidib GSE70138 HA1E Human 24h 1.11uM EID0010
Types Number Response transcription factors
Up-regulation 590 EGR1; ZNF264; NKX3-2; ZNF695; PEG3; ZNF224; ZNF345; TP73; MAML3; FEZF2; SPI1; PRDM14; MAK; KDM5A; ZNF391; ZNF154; CHD2; ZKSCAN8; CARF; ZNF75D; ZNF606; SCAI; ZNF816; ZNF362; THRA; TBR1; NFKB2; POU6F2; ZNF551; SRY; ZNF667; HIPK2; NR5A2; ZNF701; ZNF682; PRDM9; ZKSCAN4; NEUROD6; ZNF688; ZNF471; SIX6; SSX7; ALX4; VENTX; THRB; NEUROG2; TULP1; DOT1L; ASCL3; ATOH1; RBPJL; SOX21; HNF4G; ATF7; ZNF440; ZNF274; RFX1; SOX18; ZNF180; NEUROD2; HIF3A; TWIST1; ZNF235; TLX3; ZFHX2; ZNF549; ZNF343; PDX1; HOXB8; ZNF749; CIITA; FOXD3; RFX3; NEUROD4; ZNF544; MDM4; ZNF223; ZNF155; ZNF814; NFATC4; FOXO4; EMX1; SCRT1; ZNF135; FOXE3; SOX5; TAF4B; ZNF221; FOXH1; GTF2A1; CBX8; ZNF467; ZNF225; PRDM5; ZNF254; POU2F3; HEYL; ZIC3; ONECUT1; ZNF550; VGLL1; TFDP3; DCC; MLLT1; HES2; L3MBTL1; ZNF257; SOX1; ZIM2; TEF; ZNF442; NEUROG1; ZNF492; NR1H4; TBX5; ZNF423; ZSCAN2; FHL5; NR6A1; POU4F3; LHX3; TBX6; HAND1; NHLH1; E2F4; OVOL2; PROP1; PRDM16; NKX6-1; ZNF334; SP4; ZNF117; ZNF208; BCL11A; GRIP1; ZNF407; HESX1; TONSL; DLX6; HDAC5; ZNF771; ZNF573; JUP; HOXA3; FOXL1; PAX1; HSF4; ZNF80; PAX7; ZNF674; NR0B2; FOXB1; ATF6B; HOXB1; SOX14; NOCT; BRDT; NFAT5; NR2E1; KLF8; ZNF835; ZNF214; HOXD12; LMX1B; MNX1; SIX3; ZNF780B; VHL; FOXJ1; ZNF136; NACA2; GSC2; AR; TAF1C; GCM1; ZNF43; ZFP2; ZNF157; TBX1; NHLH2; POU4F2; EN1; ZNF484; CD3D; CDX1; ZNF141; ESR2; ZNF304; ETV3; UTF1; SSX3; ASH1L; ZNF215; ETV2; ZNF493; CRX; ZNF273; ZNF132; POU1F1; POU3F4; LBX1; GBX1; ZBTB3; ZNF8; HNF4A; HOXB5; HOXC5; GCM2; HNF1A; CCNT1; VSX1; NFIX; MSX2; ZBTB7C; RFXAP; HLX; ZNF710; PAX3; ZNF81; TCEA2; ZNF331; ZBTB20; LHX6; ESRRB; CDIP1; HOXD3; ZFP69B; GBX2; EPAS1; NR5A1; CDX4; IKZF2; ZIC4; TCF21; ZNF415; CALR; CREBL2; TSHZ2; TLX1; ZNF234; PAX4; IKZF3; AIRE; OVOL1; WNT4; MAPK8IP1; LIN28A; WHSC1L1; ZNF480; PRDM12; TULP2; ZNF10; PPARA; RSF1; SOHLH2; ACTL6B; TBX10; RARG; ZNF85; THAP9; NPAS1; CEBPE; RORB; ZNF669; SOX17; HAND2; ZNF41; MZF1; ZNF287; ZNF174; ZNF93; NR2C2; HOXA6; ZNF675; ZNF778; MYEF2; POU3F2; ZXDC; SLC2A4RG; CBFA2T3; NEUROG3; PAX2; ZNF124; SUPT3H; ZNF507; SKIL; MDM2; CUX2; SKI; ZNF556; NKX2-8; POU3F3; TLX2; ASCL2; ZNF711; FOXN2; ZNF460; KDM5C; KLF15; EHMT2; RFX2; ZNF623; IRF6; SALL2; MECP2; FOXF1; ZNF358; ESRRG; ZKSCAN7; THAP10; ERBB4; BARX1; ZNF764; TAF6L; MYNN; ALX3; SOX30; ZNF528; SMARCB1; ARRB1; MYCL; ZBTB7B; MEOX2; REL; AFF3; LZTR1; IKZF4; NFKBIB; MED12; ATN1; ZNF324B; ARID3A; PITX1; ZNF671; ZNF219; DLX4; MED31; EYA3; ZFP37; HOXA2; ZNF253; ARHGAP35; CREG1; ZNF142; SOX3; ST18; RORC; E2F1; HIVEP3; ONECUT2; ZXDB; ZFPM2; SIX5; TBX19; ZNF329; MXD4; ZNF112; DLX5; ING4; SRCAP; KMT2D; EMX2; IRF1; ZNF500; TAF7L; FOXA1; ZNF536; ZSCAN18; HBP1; TBX4; MECOM; SOX13; MAP3K10; TUB; NRL; ZFHX3; TBL1Y; CREM; ZNF205; ZNF665; CBX4; HIC2; TCEA1; ZSCAN31; AFF2; EBF2; PRDM8; ZSCAN9; TFAP2A; MYT1L; HDAC9; PRDM2; LHX5; SPDEF; SHOX2; ZNF91; LHX1; MEIS2; ZNF529; CBX2; NKX2-5; HLF; NR4A2; PRDM13; PKNOX2; TFAP2B; NANOG; HIC1; HOXC8; ZBTB48; FOXF2; INSR; CEBPD; CNOT3; ARNT2; ZNF35; ZFP30; HDAC11; MTA2; NEUROD1; SOX11; ZNF286A; SUV39H2; PAX6; KAT2A; ZNF611; SSBP3; GFI1; FOXP3; ZNF107; MED25; DMRT1; AES; RBL2; ESR1; TAF1; HOXD13; FOXN1; FOXA2; ZNF770; EVX1; ZBTB6; LYL1; NKX2-2; BAZ2A; HSF1; ZNF74; FOXL2; KAT2B; CERS6; PRDM10; PRDM1; ZBTB44; MNDA; POU5F1B; ID1; ISL1; RAX; DBP; TAF6; ZNF195; THAP7; FOS; BNC1; IRF8; GRHL2; EGR4; ZNF506; ELK4; NR0B1; HMBOX1; KAT6B; WDR77; PLAGL1; TULP3; TGFB1; NFIC; LDB1; RORA; MYRF; ZNF222; PRRX1; BRWD1; WT1; YBX2; NOC2L; MYCN; DLX2; HEY2; PNRC1; ZNF226; CAMTA1; ZNF552; GLI3; HEY1; KLF13; HHEX; ID3; NR4A3; LMO1; ZNF44; ZNF232; SREBF2; CBX7; ARID1A; TCF4; PHOX2B; NR1I3; CERS4; HOXB2; FOXG1; POU2F2; ZNF768; HOXD11; ZNF350; ZNF580; JAK2; NR1H3; GFI1B; SMAD5; MBD4; HOXD1; YAP1; ZNF652; TRIB3; POU2AF1; PHOX2A; ZNF184; TOX; RNF141; GTF2I; ZNF571; SMARCA1; MSX1; PBX1; HOXD10; INSM1; GATA1; EN2; MEF2C; NR2F1; CRYM; HMGA1; BRD2; TGIF2; ZNF354A; HIPK1; TFDP2; EP300; ZNF83; RBFOX2; PIR; MEIS1; PGR; STAT4; ZNF165; BAZ2B; ATF3; AEBP1; ZNF532; VPS72; ZFHX4; FOSB; NR4A1; TBX21; SOX2; PAX5; TBX2; TAL1; EHF; ZIC1; ETV5; TXNIP; ZNF589; BACH2; TCEB2; TRIM24; EGR2; E2F5; OSR2; IKZF1; MAFB; HOXB6; ETV1; TRIM22; HMGN3; E2F2; SNAI2; CEBPA; GATA2
Down-regulation 203 CCNA2; FHL2; PAX8; PUF60; CRK; NUP62; TLE1; ECD; SUV39H1; FOSL1; HNRNPD; HOXA10; CENPF; USP22; VEZF1; FOXO3; SNW1; NCOA6; NFIL3; XBP1; DNAJC2; UBE2I; TP53; NPAT; ING2; BHLHE40; CRY1; SMARCA5; TRIM32; ARID5B; RBM14; SMAD3; ZNF266; SCAND1; NRIP1; SOX4; ZNF146; FOXJ3; SUZ12; YWHAB; AATF; BRD8; CDK2; TAF9; EZH2; ADNP; HDAC2; TCERG1; DEK; PHF20; RBM39; PPRC1; HOXA5; FOSL2; EED; ATF1; KAT7; HOXC10; NKX3-1; ZFP64; BRD3; RNF111; DDX5; SMARCE1; REST; MED6; PRPF6; PRDM4; ASXL1; HMGB2; TRIM29; BCLAF1; HOXC6; ZBTB11; CEBPZ; CDK7; KLF6; MED13; TAF5; RAN; PCGF2; MBD2; MNT; STAT3; DDX54; COPS5; ZBTB1; PATZ1; MAGED1; BLM; RREB1; JARID2; ZEB2; SETD2; WHSC1; SMAD2; ENO1; NFKB1; CCDC59; PURA; FOXC1; CARM1; SERTAD2; BRPF1; RUNX1; BMI1; CNOT1; AFF1; GATAD2A; ATF4; ZNF281; URI1; CTCF; PLAGL2; BRCA1; ITGB3BP; SOX9; DR1; SFPQ; TSC22D2; ANKRD1; RNF138; BCL10; RARA; KDM2A; ZNF672; IRF7; NCOA4; PTTG1; BCOR; PREB; BAZ1A; APEX1; GTF2IRD1; CCNC; MED1; CHD1; FOXK2; NRBF2; ZNF217; ZNF302; NCOR2; KDM5D; PSPC1; ARNTL; CBX3; ZMIZ1; NFYC; RBBP4; NR2F6; NFYB; SF1; SMAD7; REPIN1; CTR9; ELF5; DNAJC1; NCOA1; FOXD1; FLNA; SIAH2; IKBKAP; TBL1XR1; ZMYM2; CTBP2; BATF3; EDF1; RBBP7; KLF10; ELF1; NR2F2; PTRF; ARID4B; ID2; NPM1; HMGB1; E2F3; CHD7; HOXB7; SMAD1; LMCD1; TLE4; SMARCA2; KLF4; HOXA11; TCF12; NFATC3; ZFP36L2; PQBP1; SP100; TBL1X; NFIB; SP110; MYBL1; TRIM16; PBX3; IFI16; BASP1; FOXO1; HTATIP2; ZBTB18; NR3C1; ABL1