Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID08031 Alvocidib GSE70138 HA1E Human 24h 3.33uM EID0010
Types Number Response transcription factors
Up-regulation 562 EGR1; ZNF264; TWIST1; CEBPD; ZNF154; PRDM14; ZNF695; FEZF2; ZNF816; CHD2; SRY; ZNF551; ZNF136; ZNF606; MAML3; ZNF701; ZNF391; SSX7; THRA; SPI1; SOX21; POU6F2; ZNF75D; ZNF667; ASCL3; OVOL2; ZNF440; CARF; ZNF224; ZNF345; ZXDC; SCAI; MAK; VENTX; TCEA2; SOX18; EMX1; L3MBTL1; ZNF682; ZNF573; ZNF749; NR5A2; TBR1; PRDM5; NEUROD2; ZNF274; ZNF223; DOT1L; ZNF362; HNF4G; NEUROD1; ZKSCAN8; RFX1; ZNF665; SOX17; NEUROD4; ZNF117; SOX5; LHX3; ZNF273; ZIC3; ZNF180; POU2F3; ERBB4; NEUROG2; RFX3; ATOH1; ZNF257; ZFPM2; FOXD3; ZNF688; HOXB8; ZKSCAN4; TP73; ZNF471; ZNF235; THRB; ASH1L; SCRT1; GBX1; FOXE3; HOXD3; PRDM9; NR6A1; ALX4; ZNF544; MECP2; VGLL1; ZNF814; ZNF423; HIPK2; AR; HESX1; ZNF304; ZNF221; ZNF549; ZNF467; ACTL6B; MYNN; HOXB1; ZNF778; RBPJL; NHLH2; HES2; SOX1; ZNF208; TFAP2A; TAF4B; ZNF442; ZNF343; CIITA; TEF; ZNF215; BCL11A; FHL5; MEIS2; ZNF550; NEUROD6; HDAC9; ZFP2; TFDP3; SP4; TBX5; ZNF492; ZNF141; ZNF334; ZNF407; ZNF674; MED31; NFATC4; NR4A2; PRDM16; ZNF214; RORC; ESRRG; ONECUT1; ZNF80; OVOL1; SSBP3; PAX4; ZNF331; HDAC5; ZNF611; MYCL; ZNF415; NEUROG1; RARG; TULP1; ZNF44; HIF3A; NACA2; FOXH1; SIX6; KLF8; CBFA2T3; ZNF287; ZNF174; WNT4; POU3F3; SHOX; IRF6; GRIP1; THAP10; POU4F3; SIX3; ZNF780B; MEOX2; SOX14; DCC; ZNF81; ZNF623; NR5A1; REL; NR1H4; HOXD1; GCM2; PDX1; BRDT; ZNF132; TLX3; GSC2; IKZF3; ZNF225; PEG3; SKIL; TULP2; ZNF10; E2F4; ZBTB20; ZNF135; VHL; FOXD2; IKZF2; ZFY; SHOX2; CDX4; FOS; ATF6B; ZIC4; SSBP2; ZNF157; ATF7; NR0B2; NKX3-2; HEYL; FOXB1; TBX1; ETV2; NFIX; HSF4; FOXL1; TBX6; TCEA1; ONECUT2; ZBTB48; ETV3; FOXJ1; WHSC1L1; CD3D; UTF1; HNF1A; ZNF155; PAX1; DLX6; POU1F1; BNC1; PAX7; HOXC5; ZFP69B; ZNF480; MLLT1; ASCL2; NHLH1; CBX4; ZNF586; SALL2; CUX2; AFF3; LBX1; ING4; ESRRB; CRX; RORB; MDM4; DLX5; CDX1; ZNF500; TCF21; ZNF835; TAF6L; CDIP1; ZNF711; ZNF43; CBX7; NKX6-1; ZNF493; HOXD12; MECOM; ZNF33B; HOXA3; MSX2; ZNF91; ZFHX2; PBX2; ZBTB44; ZNF254; ZNF232; BARX1; MAPK8IP1; HOXB5; ZNF41; TUB; NOCT; EPAS1; PRDM10; ZNF771; HBP1; HOXA2; LIN28A; ZNF557; THAP9; ZIM2; PROP1; MYT1; ZNF710; CBX2; NR2E1; MYEF2; CREM; ZNF536; CBX8; ZBTB7C; IRF8; MYF5; ZNF124; LHX6; ZBTB3; POU4F2; SOX3; ZNF253; ZNF484; ZNF507; NFKB2; ZNF140; HAND1; ESR2; KLF15; TBL1Y; CERS6; ARNT2; STAT4; PRDM2; TLX1; SSX3; EBF2; AFF2; ZNF675; CREG1; AEBP1; PAX3; PITX1; RSF1; ALX3; EHMT2; BRWD1; RFX2; NFKBIB; ZNF234; NR4A1; TFDP2; ZNF419; ZNF460; ZXDB; PAX6; AIRE; MZF1; THAP7; CERS4; ZSCAN32; JAK2; INSM1; GBX2; EN1; SUPT3H; MDM2; PRDM12; ZFP37; MNX1; FOXA1; ZNF671; LZTR1; KAT2B; TRIB3; FOXA2; MTA2; MYRF; MNDA; ESR1; ZNF286A; ZNF93; SUV39H2; ZBTB7B; CNBP; DMRT1; ZSCAN9; ZBED2; KLF13; HOXD13; ZNF134; POU3F4; FOXN1; STAT2; SRCAP; ZNF571; NKX2-5; RUVBL1; TAF1; ZNF112; ZSCAN31; ZNF556; HDAC11; CAMTA2; HLX; PBX1; PIAS4; HSF1; HIC2; SOX13; JUP; EP300; SOHLH2; NPAS1; ST18; CREBL2; GCFC2; ISL1; NFX1; ZNF350; EZH1; ZKSCAN7; EMX2; CCNT1; TFEC; TLX2; TSHZ2; ATN1; ZBTB17; SPDEF; ATF3; CEBPE; TDP2; TCF4; EN2; CALCOCO1; IRF1; GRHL2; ETV5; ZNF195; SLC2A4RG; NFIC; LMX1B; ZNF268; MAP3K10; IFNB1; HAND2; RING1; CBL; MED25; RXRG; TBX19; ZNF506; NR0B1; NR4A3; ZNF528; ZNF211; HIC1; ZNF562; TAF7L; MXI1; PKNOX2; HNF4A; NR3C2; ZNF770; RAX; NANOG; VPS72; ZNF219; PRRX1; ZNF74; GATA1; ARL2BP; FOXF1; PRDM1; BNC2; ZFP30; SNAPC4; ZNF652; TAL1; SP140; ZNF529; SOX11; ARRB1; CIR1; NR2F1; PLAGL1; ZNF426; HINFP; NR1H3; TGFB1; TBX21; NFE2L2; ZNF85; KLF3; HLF; SKI; ZNF532; RORA; IRF3; FOXG1; HIRA; PEX2; CRYM; KDM4C; ZSCAN18; NKX2-2; LDB1; ZNF329; CALR; TERF1; GFI1B; PEX14; CNOT3; RBL2; TRIM22; ZFHX4; SMARCB1; MXD1; ZNF239; ZNF107; ID1; WT1; ZNF587; GATA6; ZNF589; CREB5; LITAF; SSX1; CDK9; HOXB13; TEAD3; MYT1L; NFAT5; GFI1; SMARCA1; RNF141; TSC22D3; SOX2; INSR; NR1H2; E2F5; FOXF2; ZNF354A; BACH2; AES; SP140L; DBP; TRPS1; TOX; ZNF22; TULP3; LYL1; MEF2C; OLIG2; HHEX; ID3; ZNF165; KAT6B; RBFOX2; BCL6; HEY2; ELF3; ZNF160; LEF1; HEY1; NFE2L3; NKX2-1; SNAI2; MSX1; NR1D2; NCOA3; ZNF721; EHF; OSR2; ID4; DACH1; MEIS1; E2F2; IKZF1; ZIC1; TXNIP; CREB1; GATA2
Down-regulation 198 FHL2; CCNA2; NUP62; PAX8; TLE1; PUF60; CENPF; SUV39H1; FOXO3; HOXA10; FOXJ3; USP22; NFIL3; ECD; CRK; MYC; XBP1; FOSL1; SNW1; EZH2; SCAND1; TCERG1; TRIM32; DNAJC2; SMAD3; RBM14; HNRNPD; NFKBIA; UBE2I; NPAT; NCOA6; BHLHE40; EED; HOXC10; MYBL2; VEZF1; AATF; CDK7; HOXA5; ADNP; KAT7; TAF9; ATF1; TP53; BRD8; HOXC6; ENO1; CRY1; BLM; SETD2; MBD2; REST; MED6; HDAC2; DDX5; NFE2L1; KDM2A; JARID2; CTR9; ELF5; SMARCA5; NPM1; AFF1; BCLAF1; CCNC; MAGED1; HSF2; DDX54; PHF20; RNF111; ASXL1; SMARCE1; RFC1; RUNX1; ZMYM2; WHSC1; NKX3-1; BAZ1B; ZNF146; ARID5B; PRPF6; NCOA4; KLF6; ING2; MED13; RBBP4; CARM1; DEK; PPRC1; ELK1; HIVEP2; YWHAB; BATF; CCDC59; SOX4; MAX; CHAF1B; REPIN1; BRD3; PTTG1; PURA; BMI1; MGA; RREB1; E2F3; HOXB7; GTF2IRD1; NCOR2; RBPJ; TAF4; BASP1; PATZ1; RBM39; MLX; PSPC1; MED1; ZBTB1; SFPQ; VGLL4; SMARCA2; NRIP1; HOXA11; SAP30; FOXC1; NFKB1; NONO; KLF10; BRCA1; SMAD2; BIRC2; CNOT1; ZNF266; RLF; DMTF1; PREB; ZBTB18; TBL1X; TRIM29; ELF1; HMGB2; POLR2A; CEBPZ; SIX1; HMGB1; RCOR1; CBX3; NELFB; RAN; PQBP1; SOX9; CHD1; PSMC3IP; ELK3; TCF12; HTATIP2; ZMIZ1; HDAC7; TSC22D4; EDF1; FOXD1; FLNA; NCOA1; YBX1; DNMT3B; ZNF410; TBPL1; STAT3; SMAD7; RBBP7; BAZ1A; DNAJC1; ARID4B; ZBTB11; TBL1XR1; TSC22D2; PCGF2; NR2F6; JUND; SERTAD2; ZEB2; COPS2; CEBPB; ID2; BCOR; NRBF2; IRF7; NR2F2; RBPMS; BTG1; RUNX3; TFAP2C; ZNF217; SMAD1; MYBL1; ABL1; TOB1; NR3C1; RELB