Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID06660 Tivozanib GSE70138 CD34 Human 24h 0.12uM EID0033
Types Number Response transcription factors
Up-regulation 343 HHEX; ZHX2; MAML1; ID1; GLI2; SUPT4H1; THAP4; FOXL2; MXD3; ZBTB39; TAF12; ZSCAN31; MLLT10; PNRC1; HDAC6; MYCN; ZIM2; HDAC4; TCF7L2; ZNF184; AFF4; KLF9; HIPK3; ZNF467; SP1; BACH1; BPTF; FLI1; MEN1; CBFA2T2; GATA4; SSX1; ST18; SAP130; TOX; ZMYND11; GFI1; FOXA2; NKRF; ENY2; MED21; ID4; THAP10; AFF2; KLF4; CBFA2T3; TSC22D1; NPAT; DBP; ZNF711; FOXF1; PAWR; CIITA; PBX3; PAXBP1; KLF11; CDK7; BCL6; E2F4; MNDA; RCOR1; CARF; ZNF175; DLX5; RARG; PCGF3; L3MBTL1; CREBZF; BRWD1; ZNF180; ZNF75D; DLX2; NCOA1; NKX2-1; ZBED4; TCEA2; WNT4; YBX2; CUX1; ZBTB44; ETS2; TAF7L; NR2F1; ZFHX3; ZNF350; TRIM24; ZFPM2; RBFOX2; SMAD4; ZNF33B; MED17; FOXE1; ZNF140; HIC2; FOSL2; NR4A3; MED14; WWC1; FUBP1; IKZF2; GABPA; BCL11A; SP4; FOXJ2; ZBTB6; POU4F2; PRDM1; ZNF507; MECP2; MYRF; BRD7; TAF9B; CUX2; TFAP2A; POU2AF1; SOX18; PHIP; PROP1; GTF2I; SUMO1; HIPK1; PRDM10; ADNP2; SOHLH2; SOX3; TWIST1; RING1; MECOM; ZNF695; KLF3; TGIF1; CCNH; RARB; PROX1; NHLH2; PLAG1; ZKSCAN8; PRDM13; RREB1; PPP1R13L; CBX7; HEY1; NR4A1; LOXL2; MED25; PAX6; ZNF770; ZSCAN32; ELK4; TAF4B; FOXF2; HOXA2; PRRX1; YBX3; SOX13; ZNF239; HMGB2; GATA2; ZXDB; SHOX2; HOXB9; ZNF10; NFE2L3; PAX8; KLF13; ZFP2; MED15; TAF1C; SKIL; PBX1; CNOT6; PEG3; ZNF225; TULP2; ORC2; BTAF1; CHD2; TRIP11; ZNF552; PPARA; ZNF227; TCF20; DAXX; CBX4; ZNF529; HESX1; NFE2; SUPT3H; ZNF117; NKX3-2; EPAS1; FOXH1; MYBL1; RAD21; HBP1; ZIC3; NFYB; NFYA; ZNF571; TOB1; FOXA1; TFDP1; SMARCA1; HIVEP1; NEUROD6; ANKRD1; LEF1; STAT2; TBX3; RORC; HIRA; CTCF; ZNF674; ZNF623; MAML3; SAP30; ZNF516; PRDM14; NKX2-5; NR5A2; SOX2; CDK2; ASCL1; ZNF331; REL; ZNF665; CHD7; TSHZ2; IKZF3; SCAI; PPARGC1A; ETS1; ATOH1; ID3; TBX1; CD3D; ZNF195; ADNP; ZNF215; SATB2; CDX1; OSR2; ZNF74; EN1; E2F8; GRHL2; NR2E1; SALL2; ZNF512B; TOPORS; GATA6; YAP1; NAB2; IRF9; SSBP3; KLF5; TEAD4; NFE2L2; ISL1; VGLL1; BAZ2B; SIX6; ZFP69B; PHF1; UBE2B; NR3C2; NR4A2; PGR; IRF6; NR2C1; ZNF423; NR0B1; THAP7; SOX9; RNF138; CITED2; ZNF232; NCOA2; ZNF217; ZNF532; BNC2; TP73; TRPS1; DDX17; FEZF2; UBE2L3; TLE2; HMGB3; PEX2; ZNF652; ZNF165; POU4F1; TCF21; ARID5B; CNOT3; TAL1; ZNF12; ZNF345; ZNF304; BACH2; MEIS2; MYC; TFAP2C; LIN28A; COPS5; SALL1; DACH1; LHX2; MEIS1; EGR3; ZNF273; ZNF682; HOXC10; TERF1; RSF1; HES1; SIX3; ZKSCAN1; SOX11; HLF; CREB3L1; ARL2BP; TCEA1; ATF3; SNAI2; ZBED2; NPM1; BHLHE41; TDP2; ZNF573; ZEB1; EHF; FOXN3; ZNF264; HOXD1; SPDEF; PDLIM1; TRIM22; MKL2; TRIB3; IFI16; EMX2; TOX3
Down-regulation 99 RBBP5; PMF1; PCBD1; ZNF274; IRF7; DRAP1; HDGF; MLX; ZNF593; ZNF562; ARNTL; SNW1; IL16; ENO1; PBRM1; ETV5; TRIM32; BIRC2; PUF60; CLOCK; BCL3; ELK3; BANP; SUV39H1; SMARCE1; SFPQ; EDF1; PARP1; CTR9; TCF15; ATF5; HMGA1; NELFB; ZNF93; ARID5A; SCAND1; SND1; ATF4; ING3; NEDD8; MTF2; BBX; SP100; MSX1; SOX15; ZNF148; JUNB; USP21; ZMIZ2; NUP62; MED7; HTATIP2; ZBTB38; PA2G4; TBL1X; MED24; ZNF329; IRF5; HDAC7; SMAD1; MITF; TRIM28; ZBTB24; HNRNPD; DNAJC1; TSC22D2; SMARCD2; KDM2A; REPIN1; IRF4; ATF7IP; MEF2A; KLF2; ZNF721; BATF; TFEC; IRF8; BMI1; NRBF2; ZNF189; MAGED1; MYCBP; ZNF160; ZNF432; TAF10; HOXB7; SP110; ESR1; NFKBIA; VGLL4; XBP1; ZNF91; TCF4; MAZ; TP53; MTA1; RBPMS; MED1; TXNIP