Transcriptional response

Response ID Perturbagen Data accession Cell Source Species Duration Concentration Expression ID
RID05250 Mitoxantrone GSE70138 ASC.C Human 24h 10uM EID0070
Types Number Response transcription factors
Up-regulation 381 NFKB2; HIVEP1; NFKBIB; SRCAP; CCNE1; ZNF467; VGLL1; ZNF264; CDK2; TAF1; PAX1; HOXC5; ZNF551; CREBL2; GBX1; MYCL; ZNF710; CIITA; E2F1; GLI2; BCL11A; DLX2; TTF2; ZNF219; SOX17; AEBP1; SOX18; TCF21; ZNF652; ATOH1; HIF3A; RFX1; SSX1; HLX; SOX3; HIC2; PROP1; ZNF177; MNX1; HOXC4; HOXD11; BAZ2A; ZIM2; MAFK; TAF6L; NR4A2; ERBB4; MYRF; ESR2; TULP1; ZNF556; GMEB2; VDR; EMX1; MEF2D; GRHL2; NR2E1; VENTX; HEYL; CERS6; RORB; MEIS2; NRL; CREM; ST18; E2F4; ZNF154; ZNF124; PDX1; SUMO1; HOXB5; PBX3; SOHLH2; PRDM12; NKX2-1; ZSCAN2; SSX3; HNF4A; DLX4; SCAI; NR4A3; NR6A1; ZNF770; ZKSCAN4; ZNF688; ZNF667; ASH1L; IRF1; ALX4; CHD3; MAML3; CREB3L2; LHX6; MED15; ZNF493; LHX3; RFX3; IRF3; ZNF440; SCRT1; PIAS4; MED12; NEUROG1; CNOT3; ZNF695; MYBL2; PAX3; ZNF701; WNT4; SNAPC4; CDIP1; ZBTB7C; HAND2; STAT4; FEZF2; SKIL; HOXD3; ZBTB7B; NEUROG3; HOXD9; FOXJ1; POU6F2; ASCL3; SOX21; ACTL6A; L3MBTL1; TAF1A; MAPK8IP1; ZNF345; OVOL1; KDM5C; HIC1; ZNF117; HOXC13; NEUROD4; POU3F2; ZNF814; DMRT1; NHLH1; HIPK2; FOXL2; ZNF304; ZNF224; RAX; SSX7; PRDM1; PAX6; NFATC4; DCC; HOXD13; SRY; NR0B1; NKX6-1; ZNF816; HDAC5; TONSL; MXD3; MECP2; NEUROG2; POU3F3; NFE2L3; ZNF74; STAT2; MED14; ZNF140; PRDM2; IRF6; CEBPE; TEF; SUPT3H; RBPJL; ID4; ZNF623; ZNF506; DBP; SOX1; PRDM10; KMT2D; HNF1A; IKZF4; NPAS1; MAK; CDX4; ZNF221; SP3; LZTR1; THRB; NKX2-2; PRDM14; NFIX; ZNF536; ARID3B; NR5A2; RING1; FOXD3; GMNN; HOXB1; GATA6; NEUROD2; CUX2; PAX7; CARF; CBX2; PRDM9; ZNF835; HOXA6; ZNF157; THAP9; TCF3; ETV3; FOXE3; DOT1L; ZNF671; TLX2; RSF1; NKX2-5; KLF13; CNBP; TFDP1; HESX1; E2F8; PITX3; CDX1; ZNF471; PCGF3; TAF4B; NOC2L; ONECUT2; OVOL2; ZNF136; MLLT1; NEUROD6; TAF6; ZNF75D; TGIF2; CBX4; HOXA3; IKZF2; ZNF492; GCM2; CHD2; CRYM; BNC1; LIN28A; HHEX; ID1; CBX7; ESRRG; SOX2; ZNF215; ZNF682; ZBTB48; BARX1; SIX6; FOXH1; HSF4; ZNF711; ZNF780B; ONECUT1; HNF4G; PRDM5; FOXB1; MECOM; PITX2; HOXB2; SOX5; IRF4; GATA1; REL; TCEA1; POU2F3; TP73; ENY2; ZNF394; HOXA2; ZNF225; THAP7; PBX2; ARNTL2; NANOG; PEG3; BRWD1; ZBED2; E2F5; DLX5; ZNF232; SKI; RXRG; CAMTA2; NR4A1; VPS72; NEUROD1; ZNF135; NR0B2; ETS1; ACTL6B; DLX6; ZNF665; INSM1; TSHZ2; HOXD1; MXD1; CBFA2T2; FOSB; ZNF611; ALX3; SNAI1; GFI1B; ZNF350; ARNT2; NHLH2; JUP; ID3; C1QBP; TGFB1; TAF9B; ZNF93; ZNF257; HIRA; ZNF331; ZSCAN9; RARG; RNF138; PLAGL1; SPI1; ZNF532; IRF9; EHF; ZSCAN31; LDB1; DNMT1; WT1; TDP2; BCL11B; BACH2; KLF11; AES; NFE2; SPDEF; TCF4; TFAP2A; ZNF165; PRRX1; FOXF2; OSR2; ZFPM2; MYCN; TWIST1; ZNF512B; RAD21; ZNF107; MYBL1; SNAI2; FOXA1; HOXB6; SHOX2; SOX11; SALL2; TRIB3; KLF5; HDAC9; BAZ1A; TBX2; FOS; DACH1; CALR; LEF1; CREB1; IRF8; ZNF423; DAXX; ZIC3; ZSCAN18; EGR1; ZEB1; MEIS1; IKZF1; ZNF586; MEF2C; ATF3; E2F2
Down-regulation 129 FHL2; FOXO3; NFIL3; TLE1; CDK7; PUF60; NRIP1; USP22; MYC; SIX2; TSC22D3; FOXJ3; TCERG1; TRIM32; RNF111; CEBPB; KAT7; IKBKAP; HOXA10; TSC22D1; PATZ1; RBPJ; CREB3L1; SAP30; PURA; YAF2; NUP62; CEBPA; UBE2I; RLF; CRK; ZBTB38; SIX1; TBL1X; ZBTB11; MAGED1; DDIT3; ING2; CLOCK; TAF9; CTR9; RBBP4; ATF1; NFKBIA; AATF; NCOA6; ATF4; PPARGC1A; NR1H3; FOSL1; CCNA2; TRIM27; LIMD1; YBX3; CARM1; XBP1; RBM14; CHD9; RUVBL2; SMAD3; MLX; BHLHE40; RNF4; BTG1; BRD8; KLF6; SOX4; BASP1; ZNF263; TAF1D; NFE2L1; HTATIP2; PIR; NRBF2; ECD; BCLAF1; CEBPZ; TP53; BRD3; HOXC10; VEZF1; SIAH2; ERBB2; ETV5; ARNTL; NFIB; ADNP; ZBTB16; ZNF281; SMARCE1; ZNF189; JARID2; FOXC1; BCL6; ABL1; NR2F2; KLF2; KDM5D; FOSL2; MED1; SMARCA2; MED6; SMAD1; JUND; TRIM22; KLF9; CEBPD; TRIM29; SOX9; NPAS2; NCOA4; HOXC6; NKX3-1; TBL1XR1; ENO1; TOB1; TRIM16; YWHAB; SALL1; MYB; BHLHE41; TP63; PITX1; ZMYM2; TLE4; ELF5; CITED2; ZBTB18; SUV39H1